A5001652262- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Asthma and respiratory diseases
- Gut microbiota and health
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Immunology Research
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Inflammation biomarkers and pathways
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Ion Channels and Receptors
- Inflammasome and immune disorders
- High Altitude and Hypoxia
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
Guangzhou Medical University
2019-2025
South China University of Technology
2024-2025
Guangzhou First People's Hospital
2024-2025
State Key Laboratory of Respiratory Disease
2019-2024
First Affiliated Hospital of Guangzhou Medical University
2019-2024
Guangzhou Experimental Station
2024
Abstract Background Dysbiosis of the gut microbiome is involved in pathogenesis various diseases, but contribution microbes to progression chronic obstructive pulmonary disease (COPD) still poorly understood. Methods We carried out 16S rRNA gene sequencing and short-chain fatty acid analyses stool samples from a cohort 73 healthy controls, 67 patients with COPD GOLD stages I II severity, 32 III IV severity. Fecal microbiota three groups were then inoculated into recipient mice for total 14...
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator cardiopulmonary pathologies but its regulation via signaling remains unknown. Based on screening panel, IL-18 was identified amongst 19 cytokines to stratify and hospitalization burden in patients hospitalized with COVID-19. Supporting clinical data, administration Spike 1 (S1) glycoprotein or receptor-binding domain...
Abstract The current COVID-19 pandemic, caused by SARS-CoV-2, poses a serious public health threat. Effective therapeutic and prophylactic treatments are urgently needed. Angiotensin-converting enzyme 2 (ACE2) is functional receptor for which binds to the binding domain (RBD) of SARS-CoV-2 spike protein. Here, we developed recombinant human ACE2-Fc fusion protein (hACE2-Fc) hACE2-Fc mutant with reduced catalytic activity. both efficiently blocked entry SARS-CoV, HCoV-NL63 into...
Abstract Background The role of the microbiota in pathogenesis chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. Methods Fifty-four male Sprague-Dawley rats were exposed clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed inflammation evaluation, morphometric measurements, lung function analysis rat at three different times points during exposure. Lung gut microbial...
Background Pleural effusion (PE), frequently encountered in clinical practice, can arise from a variety of underlying conditions. Accurate differential diagnosis PE is crucial, as treatment and prognosis are heavily dependent on the etiology. However, diagnosing cause remains challenging, relying mycobacteriological methods that lack sensitivity time-consuming, or histological examinations require invasive biopsies. The recent advancements metagenomic next-generation sequencing (mNGS) have...
Chronic obstructive pulmonary disease (COPD) is a complex syndrome with poorly understood mechanisms driving its early progression (GOLD stages 1-2). Elucidating the genetic factors that influence early-stage COPD, particularly those related to airway inflammation and remodeling, crucial. This study analyzed lung tissue sequencing data from patients COPD (GSE47460) smoke-exposed mice. We employed Weighted Gene Co-Expression Network Analysis (WGCNA) machine learning identify potentially...
Chronic obstructive pulmonary disease (COPD) is one of the diseases with high mortality and morbidity complex pathogenesis. Airway remodeling an unavoidable pathological characteristic. However, molecular mechanisms airway are incompletely defined.lncRNAs highly correlated transforming growth factor beta 1(TGF-β1) expression were chosen, lncRNA ENST00000440406 (named HSP90AB1 Assoicated LncRNA 1, HSALR1) was chosen for further functional experiments. Dual luciferase ChIP assay used to detect...
<b>Severe COVID-19 patient airways plugged by MUC5AC-containing mucus exhibit hyperplasia of goblet cells, and hypoplasia multiciliated cells club as well significantly reduced CC16 MUC5B levels, increased IL-13 levels</b>https://bit.ly/2M2NcdO
In recent years, e-cigarettes have been used as alternatives among adult smokers. However, the impact of e-cigarette use on human bronchial epithelial (HBE) cells remains controversial.
Although both calcium-sensing receptor (CaSR) and canonical transient potential (TRPC) proteins contribute to chronic hypoxia (CH)-induced pulmonary arterial smooth muscle cells (PASMCs) proliferation, the relationship between CaSR TRPC in hypoxic PASMCs proliferation remains poorly understood. The goal of this study was identify that CH promotes through CaSR-TRPC pathway.Rat were isolated treated with CH. Cell assessed by cell counting, CCK-8 assay, EdU incorporation. expressions determined...
Abstract Background: Dysbiosis of the gut microbiome is involved in pathogenesis various diseases, but contribution microbes to progression chronic obstructive pulmonary disease (COPD) still poorly understood. Methods: We carried out 16S rRNA gene sequencing and short-chain fatty acid analyses stool samples from a cohort 73 healthy controls, 67 patients with COPD GOLD stages I II severity, 32 III IV severity. Fecal microbiota three groups were then inoculated into recipient mice for total 14...
Abstract Background The role of the gut microbiota in pathogenesis chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that alters microbial composition and metabolites involved disease. Methods Fifty-four male Sprague-Dawley rats were exposed clean air, biomass fuel, or motor vehicle exhaust for 4, 12, 24 weeks. Lung tissue was assessed histologically by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels measured...
Abstract Background: The role of the microbiota in pathogenesis chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. Methods: Fifty-four male Sprague-Dawley rats were exposed clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed inflammation evaluation, morphometric measurements, lung function analysis rat at three different times points during exposure. Lung gut microbial...
Abstract Background: The role of the gut microbiota in pathogenesis chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that alters microbial composition and metabolites may involved disease. Methods: Fifty-four male Sprague-Dawley rats were exposed clean air, biomass fuel, or motor vehicle exhaust for 4, 12, 24 weeks. Lung tissue was assessed histologically by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels...
Background and Objectives Accumulating evidence suggests that oxidative stress is involved in the development of chronic obstructive pulmonary disease (COPD) its progression. Activity extracellular superoxide dismutase (ecSOD), only enzyme eliminating radicals, has been reported to decline acute exacerbations COPD (AECOPD). However, association between serum ecSOD activity 1-year all-cause mortality AECOPD patients remains unclear. The objective our study was explore usefulness on admission...
Neutrophil gelatinase-associated lipocalin(NGAL) is one of the most effective biomarkers in diagnosis acute renal injury. Airway epithelial cells also produce and secrete a large amount NGAL inflammatory lung diseases. However, few studies have analyzed predictive value community-acquired pneumonia. The purpose this study was to explore whether could be applied as a novel prognostic risk classification marker levels NGAL, SAA, CRP 128 patients with CAP were measured...