A5007824285- Pulmonary Hypertension Research and Treatments
- Microbial Community Ecology and Physiology
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- RNA modifications and cancer
- Edible Oils Quality and Analysis
- Tuberculosis Research and Epidemiology
- Microplastics and Plastic Pollution
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Spectroscopy and Chemometric Analyses
- Apelin-related biomedical research
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Phagocytosis and Immune Regulation
- Advanced Nanomaterials in Catalysis
- Elasticity and Material Modeling
- interferon and immune responses
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular and Diving-Related Complications
- Cardiac Imaging and Diagnostics
- Vascular Anomalies and Treatments
- Peptidase Inhibition and Analysis
Tibet University
2022-2025
Chinese Academy of Sciences
2022-2025
Wuhan Botanical Garden
2022-2025
Jiangnan University
2024-2025
Nanjing Institute of Geography and Limnology
2025
Institute of Wetland Research
2025
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
2025
First Affiliated Hospital of Guangzhou Medical University
2022-2024
State Key Laboratory of Respiratory Disease
2022-2024
Guangzhou Medical University
2022-2024
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator cardiopulmonary pathologies but its regulation via signaling remains unknown. Based on screening panel, IL-18 was identified amongst 19 cytokines to stratify and hospitalization burden in patients hospitalized with COVID-19. Supporting clinical data, administration Spike 1 (S1) glycoprotein or receptor-binding domain...
Abstract Mycobacterium tuberculosis poses a significant global health threat. MicroRNAs play an important role in regulating host anti-mycobacterial defense; however, their apoptosis-mediated mycobacterial elimination and inflammatory response remains unclear. In this study, we explored the of microRNA-27b (miR-27b) murine macrophage responses to M. infection. We uncovered that TLR-2/MyD88/NF-κB signaling pathway induced expression miR-27b suppressed production proinflammatory factors...
Abstract Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice cultured were used investigate how protein/S-RBD impacts endothelium. Results show that S-RBD leads acute-to-prolonged induction intracellular free calcium concentration ([Ca 2+ ] i ) via acute activation TRPV4, prolonged upregulation...
BAG2 (BCL2 associated athanogene 2) is with cell fate determination in response to various pathological conditions. However, the effects of on M. tuberculosis-induced endoplasmic reticulum (ER) stress remain elusive. Herein, we report that tuberculosis infection macrophages triggered ER and downregulated expression. Overexpression enhanced autophagic flux activated macroautophagy/autophagy targeted (reticulophagy). In addition, through increasingly localizing SQSTM1 BAG2-overexpressing...
BACKGROUND: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about role deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin carboxyl-terminal hydrolase 1), a deubiquitinase, has been shown to reduce AKT1 (AKT serine/threonine kinase 1) degradation, resulting higher levels. Given that pathological hypertension, we hypothesized deficiency attenuates PAH by means reductions AKT1. METHODS:...
Rationale: Genetic studies suggest that SOX17 (SRY-related HMG-box 17) deficiency increases pulmonary arterial hypertension (PAH) risk. Objectives: On the basis of pathological roles estrogen and HIF2α (hypoxia-inducible factor 2α) signaling in artery endothelial cells (PAECs), we hypothesized is a target promotes mitochondrial function attenuates PAH development via inhibition. Methods: We used metabolic (Seahorse) promoter luciferase assays PAECs together with chronic hypoxia murine model...
Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven a phenotypic switching in pulmonary artery smooth muscle cells (PASMCs). However, the underlying mechanisms for this alteration remain incompletely understood. Here, we identified that RNA methyltransferase METTL3 significantly elevated lungs of hypoxic PH (HPH) mice and rats, as well arteries (PAs) HPH rats. Targeted deletion Mettl3 exacerbated hemodynamic consequences hypoxia-induced accelerated vivo....
The assembly processes of generalists and specialists their driving mechanisms during spatiotemporal succession is a central issue in microbial ecology but poorly researched subject the plastisphere. We investigated composition variation, succession, bacterial plastisphere, including non-biodegradable (NBMPs) biodegradable microplastics (BMPs). Although on NBMPs differed from that BMPs, colonization time mainly mediated variation. relative abundance contribution species replacement were...
ABSTRACT Long‐term climatic differences shape the ecological memory of soil bacterial communities, which refers to ability past events influence current environmental responses. However, their mechanisms and consequences for responses changes remain largely unknown, particularly in terms temporal dynamics. Therefore, communities arid (Lhasa River Basin) humid (Nyang grasslands Qinghai‐Tibet Plateau were compared explore dynamics response moisture resulting consequences. Our results indicate...
This study aims to investigate the relationship between segmental longitudinal strain (LS) and quantitative microvascular perfusion (qMVP) in patients with ST-segment elevation myocardial infarction (STEMI), explore prognostic value of two indicators after STEMI. The retrospective enrolled 61 who underwent primary percutaneous coronary intervention (pPCI) for first Microvascular (MVP) qMVP were analyzed by contrast echocardiography (MCE), LS was two-dimensional speckle tracking (2D-STE)....
Abstract Human tuberculosis (TB), caused by Mycobacterium ( Mtb ), remains a leading global health problem, causing 1.3 million deaths each year. The nuclear body protein, Sp110, has been linked to TB resistance and previous work showed that it enhances macrophage apoptosis upon infection. Here, we report on the role of Sp110 in transcriptional regulation responses through integrated transcriptome mechanistic studies. Transcriptome analysis revealed regulates genes involved immune responses,...
Succession is a fundamental aspect of ecological theory, but studies on temporal succession trajectories and driving mechanisms plastisphere microbial communities across diverse colonization environments remain scarce poorly understood. To fill this knowledge gap, we assessed the primary colonizers, trajectories, assembly, turnover prokaryotes eukaryotes from four freshwater lakes. Our results show that differences in composition similarity, rate, assembly processes do not exclusively occur...
ABSTRACT Background Right ventricular (RV) diastolic function and right atrial (RA) are poorly characterized in patients with obstructive sleep apnea syndrome (OSAS), but may influence exercise capacity. We aimed to evaluate RA RV OSAS study their relationship Methods Fifty‐three thirty age‐ gender‐matched controls prospectively underwent echocardiography cardiopulmonary testing investigate function, Results Altered severe was indicated by the increased tricuspid valve E/e′ ratio (TV E/e′),...
Autophagy plays an important role in the pathogenesis of pulmonary hypertension (PH). ROC-325 is a novel small molecule lysosomal autophagy inhibitor that has more potent anticancer activity than antimalarial drug hydroxychloroquine, latter been prevalently used to inhibit autophagy. Here, we sought determine therapeutic benefit and mechanism action experimental PH models.Hemodynamics, echocardiography, histology measurement showed treatment prevented development PH, right ventricular...
Background. Pulmonary arterial hypertension (PAH) is a complex pulmonary vasculature disease characterized by progressive obliteration of small arteries and persistent increase in vascular resistance, resulting right heart failure death if left untreated. Artemisinin (ARS) its derivatives, which are common antimalarial drugs, have been found to possess broad range biological effects. Here, we sought determine the therapeutic benefit mechanism ARS derivatives treatment experimental (PH)...
Abstract Powder porous carbon (PPC) has been fabricated by using corncob, a by‐product of corn production, through simple calcination process. The relevant material retains an intrinsic structure and large specific surface area 577.15 m 2 /g. oxidase‐like peroxidase‐like activities based on corncob are explored in the pH range 2.0‐8.0, temperature between 15 60 °C, optimal at physiological temperature. According to fluorescence scavenger measurements, catalytic mechanism with...
The endothelial dysfunction and the consequent attenuated pulmonary vasodilatation are major causes of elevated arterial resistance pressure in hypertension (PAH). Current study aimed to explore effects a TOR2A gene product, salusin-β, on endothelium-dependent vascular relaxation progression PAH monocrotaline (MCT)-induced rats as well relevant signaling pathway.Acetylcholine (ACh)-induced dose-dependent was used evaluate function.The salusin-β level plasma artery (PA) MCT-PAH were...