A5031961745- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Tracheal and airway disorders
- Ion Channels and Receptors
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Retinal Imaging and Analysis
- Ubiquitin and proteasome pathways
- Pelvic and Acetabular Injuries
- Cancer, Hypoxia, and Metabolism
- Glaucoma and retinal disorders
- Erythrocyte Function and Pathophysiology
- Obstructive Sleep Apnea Research
- Esophageal and GI Pathology
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Peroxisome Proliferator-Activated Receptors
- Skin Protection and Aging
- Ferroptosis and cancer prognosis
- Cardiovascular Issues in Pregnancy
- Respiratory Support and Mechanisms
- Spinal Fractures and Fixation Techniques
First Affiliated Hospital of Guangzhou Medical University
2016-2025
State Key Laboratory of Respiratory Disease
2016-2025
Guangzhou Medical University
2016-2025
Chengdu University
2024-2025
Hainan Medical University
2025
National Clinical Research
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guang’anmen Hospital
2024
Wenzhou Medical University
2011-2023
First Affiliated Hospital of Kunming Medical University
2023
Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic pulmonary fibrosis (IPF). Senescence and insufficient mitophagy fibroblasts contribute their differentiation into myofibroblasts, thereby promoting the development lung fibrosis. Bone morphogenetic protein 4 (BMP4), a multifunctional growth factor, essential for early stage development; however, role BMP4 modulating remains unknown.The aim this study was evaluate using BMP4-haplodeleted mice, BMP4-overexpressed primary...
BACKGROUND: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the of Piezo2 PH remains unclear. METHODS: Endothelial cell (EC)–specific knockout ( flox/flox , Tek-Cre + ; EC−/− ) rats and primarily cultured microvascular ECs were used to determine PH. RESULTS: Data analysis publicly accessible single-cell RNA-sequencing data sets uncovered significant downregulation lung from patients with idiopathic arterial hypertension, which was verified lungs/ECs...
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Abstract Background Phellinus linteus (PL), which is a typical medicinal fungus, has been shown to have antitumor and anti-inflammatory activities. However, studies on the effect of anti-photoaging are limited. Studies that exosome-like nanovesicles functional components many plants, miRNAs in play cross-kingdom regulatory role. At present, research fungi (FELNVs) few. Results We systematically evaluated anti-aging effects PL. FELNVs PL were isolated, molecular mechanisms evaluated. The...
Trimethylamine N-oxide (TMAO), a metabolite derived from intestine microbial flora, enhances vascular inflammation in variety of cardiovascular diseases, and the bacterial communities associated with TMAO metabolism are higher pulmonary hypertension (PH) patients. The effects on PH, however, have not been elucidated. In present study, circulating was found to be elevated intermediate high-risk PH patients when compared healthy control or low-risk monocrotaline-induced rat models, elevated;...
Abstract Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice cultured were used investigate how protein/S-RBD impacts endothelium. Results show that S-RBD leads acute-to-prolonged induction intracellular free calcium concentration ([Ca 2+ ] i ) via acute activation TRPV4, prolonged upregulation...
The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature its potential correlation with clinical parameters of PH. Overall, 244 patients PH 120 healthy controls (CON) were recruited from three independent centers. group was divided into subgroups not using antibiotics or corticosteroids (non-ANT/CORT), those ANT, CORT, ANT + CORT within 1 month, classification (Groups 1, 3, 4), World Health Organization...
Stent implantation is a well-accepted alternative to treat benign luminal disease (BLD). Current stents are often fabricated from plastic, mental and biodegradable materials, the latter two have wider clinical application. Self-expanding plastic possessed many disadvantages such as stent migration, tissue hyperplasia, in-stent restenosis difficult remove, which catalyzes development of (BDS). In fact, BDS not required be removed upon implementation leaves no residues in after complete...
Danshen, the dried root of Salvia miltiorrhiza, is widely used in clinics China for treating various diseases, including cardiovascular diseases. Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative isolated as major active component from was recently reported to be effective attenuating characteristic pulmonary vascular changes associated with chronically hypoxic hypertension (CHPH); however, underlying detailed mechanisms are poorly understood. In this study, we investigated...
The tumor-suppressive role of p53, a transcription factor that regulates the expression many genes, has been linked to cell cycle arrest, apoptosis, and senescence. noncanonical function or pathogenic p53 more recently implicated in pulmonary vascular disease. We previously reported rapid nuclear accumulation hypoxia-inducible (HIF)-1α arterial smooth muscle cells (PASMCs) upregulates transient receptor potential channels enhances Ca2+ entry increase cytosolic concentration ([Ca2+]cyt)....
Many external factors can induce the melanogenesis and inflammation of skin. Salidroside (SAL) is main active ingredient
Tetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and fermented Japanese food natto has since been synthesized. TMP a long history of beneficial effects in treatment many cardiovascular diseases. Here we have evaluated therapeutic on pulmonary hypertension (PH) animal models patients with arterial (PAH) or chronic thromboembolic (CTEPH).Three well-defined PH -chronic hypoxia (10% O2 )-induced (HPH), monocrotaline-induced (MCT-PH) Sugen...
Pulmonary hypertension related to pulmonary fibrosis is classed as WHO Group III, one of the most common groups which lacks effective treatment options. In this study, we aimed uncover underlying mechanisms, particularly involvement BMP9/BMPR2/SMAD signalling pathway, in subtype hypertension.Male Sprague Dawley rats were used establish a model with fibrosis, induced by bleomycin. Haemodynamic and lung functions measured, along histological immunohistochemical examinations. Primary cultures...
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To clarify the possible mechanism of cigarette smoke (CS)-induced pulmonary hypertension and furthermore provide effective targets for prevention treatment, effects chronic CS on rat arterial smooth muscle in vivo nicotine treatment cells (PASMCs) vitro were investigated. In this study, we demonstrated that exposure led to weight loss, right ventricular hypertrophy, remodeling. A fluorescence microscope was used measure intracellular calcium concentration ([Ca(2+)]i) distal PASMCs. Results...
Previously we demonstrated that both hypoxia inducible factor-1 (HIF-1) and bone morphogenetic protein-4 (BMP4) up-regulate transient receptor potential canonical (TRPC) 1 TRPC6, resulting in increased basal intracellular Ca2+ concentration ([Ca2+]i) pulmonary arterial smooth muscle cells (PASMCs), driving development of chronic (CH)-induced hypertension (CHPH). This study aims to determine whether HIF-1 regulates BMP4, BMP4 mediates TRPC [Ca2+]i increases hypoxic PASMCs. The level mature...
Previous studies have demonstrated that besides the classic canonical transient receptor potential channel family, Orai family and stromal interaction molecule 1 (STIM1) might also be involved in regulation of store-operated calcium channels (SOCCs). An increase cytosolic free Ca2+ concentration promoted by entry (SOCE) pulmonary arterial smooth muscle cells (PASMCs) is a major trigger for vasoconstriction proliferation migration PASMCs. In this study, our data revealed following: (1) both...
Alteration in microbiota composition of respiratory tract has been reported the progression many chronic lung diseases, yet, correlation and causal link between disease development pulmonary hypertension (PH) remain largely unknown. This study aims to define compare pharyngeal swab samples patients with PH reference subjects. A total 118 79 subjects were recruited, collected sequence 16S ribosomal RNA (16S rRNA) V3-V4 region microbiome. The relative abundances profoundly different from Ace...
Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process pulmonary arterial hypertension (PAH). BMP4 plays an important role during remodeling and mutant principle receptor, BMP receptors II (BMPRII), is found to associate with development PAH. However, likely mechanism defining contribution BMPRII mediated smooth muscle cells (PASMCs) remains comprehensively unclear. We previously that enhanced store operated calcium entry (SOCE) basal...
Our laboratory previously showed that sodium tanshinone IIA sulfonate (STS) inhibited store-operated Ca(2+) entry (SOCE) through channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC), which contribute to formation SOCC (Wang J, Jiang Q, Wan L, Yang K, Zhang Y, Chen Wang E, Lai N, Zhao H, Sun Zhong Ran P, Lu W. Am J Respir Cell Mol Biol 48: 125-134, 2013). The detailed molecular mechanisms by STS inhibits SOCE and downregulates TRPC,...