A5042249930- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- Chromatography in Natural Products
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Studies
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Biological Activities
- Viral Infections and Vectors
- Drug-Induced Hepatotoxicity and Protection
- Biological and pharmacological studies of plants
- Identification and Quantification in Food
- Fungal Biology and Applications
- Toxoplasma gondii Research Studies
- Bioactive Compounds and Antitumor Agents
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Drug Transport and Resistance Mechanisms
- Mosquito-borne diseases and control
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Medicinal Plants and Bioactive Compounds
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Jilin Agricultural University
2011-2025
National Institutes for Food and Drug Control
2016-2025
Ningbo Center for Disease Control and Prevention
2025
Shanghai Second People's Hospital
2024
First Hospital of Jilin University
2017-2024
Jilin University
2010-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
BACKGROUND: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the of Piezo2 PH remains unclear. METHODS: Endothelial cell (EC)–specific knockout ( flox/flox , Tek-Cre + ; EC−/− ) rats and primarily cultured microvascular ECs were used to determine PH. RESULTS: Data analysis publicly accessible single-cell RNA-sequencing data sets uncovered significant downregulation lung from patients with idiopathic arterial hypertension, which was verified lungs/ECs...
Abstract Alternative medicines are commonly used for the disease prevention and treatment worldwide. Aristolochic acid (AAI) nephropathy (AAN) is a common rapidly progressive interstitial caused by ingestion of Aristolochia herbal medications. Available data on pathophysiology molecular mechanisms AAN limited were explored here. SD rats randomized to control groups. group was treated with AAI oral gavage 12 weeks observed additional weeks. Kidneys processed histological evaluation, Western...
Abstract Chronic kidney disease (CKD) is a major public health problem worldwide. Rhubarb has been shown to have nephroprotective and anti-fibrotic activities in patients with CKD. However, bioactive fractions biochemical mechanism of properties rhubarb remain unclear. Here we applied ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry together univariate multivariate statistical analyses investigate the urinary metabolite profile rats adenine-induced CKD...
Chronic kidney disease (CKD) is becoming a worldwide public health problem. In this study, metabonomics method based on the ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS(E) data collection technique was undertaken to explore excretion pattern of low molecular metabolites in rat model adenine-induced chronic renal failure (CRF). Coupled blood biochemistry and histopathology results, significant difference metabolic profiling between CRF group control by...
Chronic renal failure (CRF) is a major public health problem worldwide. Earlier studies have revealed salutary effects of rhubarb extracts in CRF. In this study, we employed lipidomic and metabolomic approaches to identify the plasma biomarkers determine effect treatment with petroleum ether, ethyl acetate n-butanol rat model CRF adenine-induced chronic tubulointerstitial nephropathy. addition, clinical biochemistry, histological evaluation pro-fibrotic protein expression were analyzed....
Abstract We identified Yezo virus infection in a febrile patient who had tick bite northeastern China, where 0.5% of Ixodes persulcatus ticks were positive for viral RNA. Clinicians should be aware this potential health threat and include emerging the differential diagnosis tick-bitten patients region.
An ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF MS) metabonomics approach was employed to study the serum metabolic profiling of adenine-induced chronic renal failure (CRF) rats. Acquired data were subjected principal component analysis (PCA) for differentiating CRF and normal control groups. Potential biomarkers screened by using S-plot identified accurate mass, isotopic pattern MS/MS fragments information obtained from UPLC MS...
In the present study, 168 pesticides in 1,017 samples of 10 Chinese herbal medicines (CHMs) were simultaneously determined by high-performance liquid (HPLC-MS/MS) and gas (GC-MS/MS) chromatography-tandem mass spectrometry. A total 89.2% encompassed one or multiple pesticide residues, residue concentrations 60.5% less than 0.02 mg kg-1, revealing relatively low levels. The hazard quotient index methods used to estimate health risk for consumers. For a more accurate assessment, exposure...
The raw and processed Polygonum multiflorum Thunb (PM) are used to treat different diseases, PM has also been reported have hepatotoxic effects. Moreover, mounting evidence indicates that is less toxic than PM. changes in efficacy toxicity of during the processing closely related chemical composition. Previous studies mainly focused on anthraquinone stilbene glycosides process. Polysaccharides, as main components PM, showed many pharmacological effects, but its neglected for a long time. In...
Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MSE data collection mode was developed as very effective biochemical analytical tool precise identification of important biomarkers in adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic combined multivariate analysis, accurate mass, isotopic pattern, fragments information and MassLynx i-FIT algorithm. The indicated perturbations bile...
Chronic kidney disease (CKD) is an important public health problem. Ergone has been proved to prevent the progression of CKD. UPLC-QTOF/HDMS was employed for metabolic profiling adenine-induced CKD and investigate nephroprotective effects ergone. Pharmacology parameters including blood biochemistry, histopathological evaluation Western blot analysis were performed concurrently. The UPLC-MS data analyzed by partial least squares-discriminate analysis, correlation heatmap mapped KEGG pathways....