A5101831731- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Drug-Induced Hepatotoxicity and Protection
- Macrophage Migration Inhibitory Factor
- Concrete and Cement Materials Research
- Supercapacitor Materials and Fabrication
- Peptidase Inhibition and Analysis
- Innovative concrete reinforcement materials
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Effects of Natural Compounds
- Bacteriophages and microbial interactions
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Blood disorders and treatments
- Phytochemistry and Bioactivity Studies
- Liver physiology and pathology
- Traditional Chinese Medicine Analysis
- Allergic Rhinitis and Sensitization
Chongqing Medical University
2013-2025
Wannan Medical College
2025
First Affiliated Hospital of Wannan Medical College
2025
Guangzhou Medical University
2023-2024
North China University of Water Resources and Electric Power
2024
Memorial Sloan Kettering Cancer Center
2024
West China Hospital of Sichuan University
2024
Sichuan University
2024
Guangzhou Women and Children Medical Center
2023
China International Science and Technology Cooperation
2016-2023
Abstract Immune-checkpoint protein V-domain immunoglobulin suppressor of T-cell activation (VISTA) controls antitumor immunity and is a valuable target for cancer immunotherapy. This study identified role VISTA in regulating Toll-like receptor (TLR) signaling myeloid cells controlling cell–mediated inflammation immunosuppression. modulated the polyubiquitination expression TRAF6. Consequently, dampened TLR-mediated MAPK/AP-1 IKK/NF-κB cascades. At cellular levels, regulated effector...
In the present study, 168 pesticides in 1,017 samples of 10 Chinese herbal medicines (CHMs) were simultaneously determined by high-performance liquid (HPLC-MS/MS) and gas (GC-MS/MS) chromatography-tandem mass spectrometry. A total 89.2% encompassed one or multiple pesticide residues, residue concentrations 60.5% less than 0.02 mg kg-1, revealing relatively low levels. The hazard quotient index methods used to estimate health risk for consumers. For a more accurate assessment, exposure...
Curcumin was recently discovered to strengthen immune response through multiple mechanisms. Cytotoxic CD8+ T-cells play a critical role in modulating anticancer response, but is severely restricted by T-cell exhaustion. Bladder carcinomas express PD-L1 and can abrogate response. Thus, we hypothesized that bisdemethoxycurcumin, natural dimethoxy derivative of curcumin, may provide favorable environment for against bladder cancer when used combination with α-PD-L1 antibody. Immunocompetent...
γδ T cells are evolutionarily conserved lymphocytes that manifest unique antitumor efficacy independent of tumor mutation burden (TMB) and conventional human leukocyte antigen (HLA) recognition. However, the dynamic changes in their cell receptor (TCR) repertoire during cancer progression treatment courses remain unclear. Here, a comprehensive characterization γδTCR repertoires performed thyroid cancers with divergent differentiation states through cross-sectional studies. The findings...
Ecological water replenishment is an important measure for conserving sources and improving the environment. To explore evolution causes of groundwater chemistry after ecological in Jialu River, this study utilized monitoring data from 2015 to 2019 following replenishment. Various methods, including Piper's trilinear diagram, Gibbs principal component analysis, ion ratio were employed research purposes. The results indicate that (1) since implementation there has been a general downwards...
Mammalian stanniocalcin 2 (STC2) is a glycoprotein hormone with multiple functions. The present study determined the importance of STC2 in osteoblast differentiation. It was revealed that expression increased during differentiation MC3T3-E1 cells to osteoblasts and knockdown reduced mineralization, whereas overexpression mineralization. Knockdown downregulated osteoblast-associated genes, including runt‑related transcription factor 2, collagen type I α 1 chain, osterix osteocalcin....
Abstract Background Juvenile idiopathic arthritis ( JIA ) has three major onset types with widely varying clinical features: systemic, polyarticular and pauciarticular. We assessed natural killer NK cell function immunoglobulin‐like receptor KIR genotypes in patients different subtypes. Methods Peripheral blood samples from 72 children active (systemic, 25; polyarticular, 24; pauciarticular, 23) 25 controls were used for flow cytometric assessments of count, cytotoxicity, perforin, granzyme...
To investigate the clinical features and prognoses of children who develop reversible posterior encephalopathy syndrome (RPES) during treatment for nephrotic (NS).The clinicoradiological characteristics 51 patients with NS, including 21 RPES 30 without, were analyzed.Compared controls, exhibited a higher rate tacrolimus (P = 0.01) cyclosporine 0.02) treatment; higher-dose prednisolone systolic blood pressure 0.04), serum cholesterol 0.03), proteinuria < 0.01); lower albumin levels 0.03)....
BackgroundAntibody-mediated rejection (ABMR) significantly affects transplanted kidney survival, yet the macrophage phenotype, ontogeny, and mechanisms in ABMR remain unclear.MethodMethod: We analyzed post-transplant sequencing clinical data from GEO ArrayExpress. Using dimensionality reduction clustering on scRNA-seq data, we identified subpopulations compared their infiltration non-rejection cases. Cibersort quantified these bulk samples. Cellchat, SCENIC, monocle2, monocle3 helped explore...
Fully utilizing solid waste as supplementary cementitious materials (SCMs) while ensuring the mechanical properties of cement-based is one pathways for carbon reduction in cement industry. Understanding effects two wastes-limestone powder (LP) and rice husk ash (RHA) on great significance their application concrete. This study investigates impact LP RHA strength mortar at various ages microhardness hardened paste. The results suggest that have a certain synergistic effect materials. addition...
As the incidence of allergic asthma in children increases, immunoglobin E (IgE) molecular sensitization profile remains underreported while level total IgE (tIgE) and sIgE/tIgE have not been studied as predictors efficacy allergen immunotherapy (AIT) for asthma, specifically children.Starting from August 2018 to March 2019 Respiratory Department Children's Hospital Chongqing Medical University, asthmatic children, with positive skin prick tests Der p or f, were enrolled this study. Total...
NKG2D provides a costimulatory signal for activation of CD4+ T cells. We explored its role in interactions cells and dendritic (DCs) juvenile idiopathic arthritis (JIA) patients by using genetically modified found active JIA had significantly higher content CD4 + NKG2D+ than healthy controls. Expression on cells, MICA MICB DCs were greater articular systemic JIA. induced IL- 12 suppressed IL-10 TGF-β from increased IFN-γ IL-17+ RORc T-bet, but reduced CD25+ Foxp3+ IL-4+ Foxp3, GATA3...
Abstract Objective To analyze the disease profiles and associated burdens of hospitalized children with rare disorders. Study design: Clinical data 1,975 disorders from 2012 to 2018 at a single medical center in western China were retrospectively analyzed. A family-structured questionnaire survey was conducted on 200 10 these diseases, capturing demographic information, family economic status, costs, compliance behavior, outpatient inpatient service use, psychological burden parents....
To reduce the mining of high-grade magnesite and solve environmental pollution caused by tailings, tailings were used to produce MgO expansion agent (MEA), a detailed study its performance was carried out in this study. Firstly, effects different calcination times on products, specific surface area, activity MEA analyzed. Then, produced calcinating at 950 °C for 1 h taken as research object, content performance, compressive strength, flexural strength mortar studied. The results showed that...