A5077624972- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Pediatric health and respiratory diseases
- Synthesis and biological activity
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Neurogenetic and Muscular Disorders Research
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Cancer survivorship and care
- Diabetes and associated disorders
- Renal Transplantation Outcomes and Treatments
- Microbial Natural Products and Biosynthesis
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- Antifungal resistance and susceptibility
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
Children's Hospital of Chongqing Medical University
2014-2025
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Chongqing Medical University
2014-2025
National Clinical Research
2025
China International Science and Technology Cooperation
2020-2024
Second Hospital of Shanxi Medical University
2009-2024
Shanghai Clinical Research Center
2024
Chongqing Maternal and Child Health Hospital
2024
Shanxi Medical University
2009-2023
Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic conducted 1868 Chinese cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional...
Follicular helper T (Tfh) cells are specialized in helping B lymphocytes, which play a central role autoimmune diseases that have major cell component, such as rheumatoid arthritis (RA). regulatory (Tfr) control the over-activation of Tfh and germinal centers. Dysregulation Tfr has been reported to be involved pathogenesis some diseases. However, balance cells, their roles development progression RA still not clear. In this study, we enrolled 44 patients with (20 active 24 inactive RA) 20...
Background Infections are the major cause of morbidity and mortality in patients with primary immunodeficiency disease (PID). Timely accurate microbiological diagnosis is particularly important these patients. Metagenomic next-generation sequencing (mNGS) has been used for pathogen detection recently. However, few reports describe use mNGS identification PID. Objective To evaluate utility detecting pathogens PID, to compare it conventional tests (CMT). Methods This single center...
Abstract Macrophage activation syndrome (MAS) is a rare, potentially life-threatening condition in rheumatic diseases. The main treatment includes high-dose corticosteroids and immunosuppressive drugs, although cytokine inhibitors like anakinra or tocilizumab (TCZ) have been reported more recently. We report one case child with systemic juvenile idiopathic arthritis (sJIA). He became progressively hypoxic was transferred to the paediatric intensive care unit (PICU) after TCZ for 4 days. An...
CD40 ligand (CD40L) deficiency is a rare but life-threatening primary immunodeficiency caused by mutations in the CD40L gene. Here, we investigated cohort of 40 genetically diagnosed CD40L-deficient patients from Chinese mainland, analysed their clinical and genetic data, examined expression, proportion T cell subsets, B subsets follicular helper (Tfh) cells. The aim was to provide complete picture deficiency. Initial presentations patient mainly involved recurrent fever (47.5%)...
T-cell receptor (TCR) diversity is crucial for adaptive immunity, yet baseline characterizations in pediatric populations remain sparse. We sequenced the TCRβ chain of 325 healthy Chinese children aged 0-18, categorized into six age groups. also analyzed cellular composition and associations using flow cytometry 81 these samples. Our results indicate a decrease with age, characterized by an increase high-frequency clonotypes notable changes CDR3 length V(D)J gene usage. These are influenced...
Deficiency in ELF4, X-linked (DEX) is a newly identified monogenic autoinflammatory disease. Most reported cases are male, leading to the recognition of DEX being primarily limited male patients. Here we described 3 pediatric female patients with from unrelated families, who all heterozygous for ELF4 mutations (c.320_c.321insA, c.329delA and c.685 A > G). Similar patients, main clinical features include recurring oral ulcers, abdominal pain diarrhea colonoscopy showing ulcers colon....
Journal Article Accepted manuscript Efficacy of upadacitinib in treating a paediatric case refractory Takayasu arteritis Get access Bochun Liang, Liang Division Rheumatology and Immunology, Children's Hospital Chongqing Medical University, Chongqing, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Xiwen Luo, Luo Zhiyong Zhang, Zhang ChinaMinistry Education Key Laboratory Child Development Disorders, ChinaChongqing Infection Immunity, Yunfei An, An Xi...
Not required for Clinical Vignette.
Introduction Type 2 diabetes mellitus (T2DM) is often accompanied by bone metabolic disorders and cognitive impairment, forming an interactive network through derangements, oxidative stress, inflammatory responses. Hyperglycemia insulin resistance disrupt remodeling leading to osteoporosis while simultaneously impairing cognition via blood-brain barrier damage neuroinflammation. Osteogenic factors like osteocalcin may bidirectionally regulate glucose metabolism brain function, suggesting...
This questionnaire-based study provides insights into the current healthcare infrastructure used to diagnose and manage inborn errors of immunity across countries regions involved in Asia-Pacific Society for Immunodeficiencies.