A5036566273- Gout, Hyperuricemia, Uric Acid
- Porphyrin Metabolism and Disorders
- Biochemical and Molecular Research
- Protein purification and stability
- Biotin and Related Studies
- Acute Lymphoblastic Leukemia research
- Methemoglobinemia and Tumor Lysis Syndrome
- Dermatological diseases and infestations
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Plant Toxicity and Pharmacological Properties
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Phosphodiesterase function and regulation
- Insect Pest Control Strategies
- Hemoglobin structure and function
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Chemical Synthesis and Analysis
Wuhan University
2013-2025
Sixth Affiliated Hospital of Kunming Medical University
2021-2025
Kunming Medical University
2021-2025
Renmin Hospital of Wuhan University
2010-2025
Zhongnan Hospital of Wuhan University
2025
Southwest University of Science and Technology
2025
Geophysical Survey
2025
Chongqing Cancer Hospital
2023-2024
Chongqing University
2003-2024
Affiliated Eye Hospital of Wenzhou Medical College
2022-2024
MicroRNA (miRNA) is involved in the genesis viand development of colorectal cancer. The vivo imaging miRNA at tumor sites essential for understanding its role cancer pathology and therapeutic target identification. However, achieving accurate hindered by low abundance miRNAs cells nonspecific signal leakage normal tissues. Here, we report a multivariate-gated catalytic hairpin assembly (CHA) nanosensor specific amplified microRNA-21 (miR-21) human tissues to reveal underlying...
Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic conducted 1868 Chinese cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional...
To reduce the high incidence and mortality of gastric cancer (GC), we aimed to develop deep learning-based models assist in predicting diagnosis overall survival (OS) GC patients using pathological images.
Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns metastasis without systematical genomic investigation. Here, we evaluated evolution CRC with multiorgan metastases using multiregion sequencing. Design Whole-exome sequencing was performed on multiple regions (n=74) matched primary tumour, adjacent non-cancerous mucosa, liver lung from six patients CRC. Phylogenetic reconstruction evolutionary analyses were used to...
First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process UA in consists two stages—oxidation followed by hydration. The oxidation four steps: (1) chemical transformation from 8-hydroxyxythine an anionic radical via a proton transfer along with electron transfer, which is different previously proposed electron-transfer...
Cancer stem cells (CSCs) proliferate extensively and drive tumor metastasis recurrence. CSCs have been identified in over 20 cancer types to date, but it remains unknown how target eliminate vivo. Aldehyde dehydrogenase (ALDH) is a marker that has used for isolating CSCs. Here we present novel approach reduce the frequency of ALDHhigh by vaccination against ALDH. We ALDH1-A1 ALDH1-A3 epitopes from developed synthetic high-density lipoprotein nanodiscs Nanodiscs increased antigen trafficking...
Objectives An outbreak of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has sickened thousands people in China. The purpose this study was to explore early clinical characteristics COVID-19 patients with cardiovascular disease (CVD). Methods This is a retrospective analysis from single centre. All underwent real-time reverse transcription PCR for SARS-CoV-2 on admission. Demographic and factors laboratory data were reviewed collected evaluate significant...
Background Endoplasmic reticulum stress (ERS) is a critical factor in the development of ulcerative colitis (UC); however, underlying molecular mechanisms remain unclear. This study aims to identify pivotal related ERS UC pathogenesis and provide novel therapeutic targets for UC. Methods Colon tissue gene expression profiles clinical information patients healthy controls were obtained from Gene Expression Omnibus (GEO) database, ERS-related set was downloaded GeneCards analysis. Weighted...
Abstract Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Phases I‐III Regulatory, Quality, Manufacturing Postmarketing Phase IV Treatment of refractory gout remains a challenge on drug development. While pegloticase, recombinant mammalian uricase modified with monomethoxyl poly(ethylene glycol) ( mPEG ) is effective in treating gout, after continued treatment for...
Esophageal cancer is of high prevalence and poor prognosis. Hesperetin has been reported to exert antitumor ability by inducing apoptosis in many cancers vitro vivo without obvious toxicity. However, there no study concerning about the effect hesperetin on esophageal cancer. In this study, we aimed investigate whether could induce cells explore its potential mechanism. We found that induced a concentration-dependent time-dependent manner compared with untreated cells. Hoechst 33258 staining...
A humanoid robot is an advanced representation of techniques. It can move like a human and possesses the ability to use tools. Sensing intelligent control technologies have increased intelligence robots. However, dexterity still far from that human. Herein, bending sensor introduced detect motion, which thus be digitized enable learn more dexterous. This fabricated carbon fiber with cascade structure, resulting in excellent characteristics, including quantitative detection capability, high...
Litchi leaf diseases and pests can lead to issues such as a decreased yield, reduced fruit quality, farmer income. In this study, we aimed explore real-time accurate method for identifying pests. We selected three different orchards field investigation identified five common (Litchi mite, sooty mold, anthracnose, Mayetiola sp., algal spot) our research objects. Finally, proposed an improved fully convolutional one-stage object detection (FCOS) network disease pest detection, called FCOS...
Herein, network pharmacology was used to identify the active components in Ilex kudingcha and common hypertension-related targets. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) enrichment analyses were conducted, molecular docking performed verify dynamic simulations. Six identified; furthermore, 123 target genes hypertension identified. Topological analysis revealed strongly associated proteins, with RELA , AKT1 JUN TP53 TNF MAPK1 being predicted targets studied traditional...
Abstract Previous studies have demonstrated the therapeutic effects of regulatory T (Treg) cells on inflammatory bowel disease (IBD), but mechanism is not well‐understood. Exosomes been proposed as a novel underlying action Tregs. This study aimed to investigate exosomes secreted by Treg (Treg‐Exo) IBD and explore mechanism. Treg‐Exo was isolated from BALB/c mouse spleen mononuclear then injected into murine model induced dextran sodium sulfate (DSS) exposure. A co‐culture colonic epithelial...
The anterior cingulate cortex (ACC) is a core brain region processing pain emotion. In this study, we performed RNA sequencing analysis to reveal transcriptomic profiles of the ACC in rat chronic constriction injury (CCI) model. A total 1628 differentially expressed genes (DEGs) were identified by comparing sham-operated rats with 12 hours, 1, 3, 7, and 14 days after surgery, respectively. Although these inflammatory-related DEGs generally increased CCI, different kinetics time-series...
Abstract Background The choice of polypectomy device and surveillance intervals for colorectal polyps are primarily decided by polyp size. We developed a deep learning-based system (ENDOANGEL-CPS) to estimate size in real time. Methods ENDOANGEL-CPS calculates estimating the distance from endoscope lens using parameters lens. depth estimator network was on 7297 images five virtually produced colon videos tested 730 seven virtual videos. performance first evaluated nine simulated with...