A5056696999- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Gut microbiota and health
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Clostridium difficile and Clostridium perfringens research
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Simulation-Based Education in Healthcare
- Music Therapy and Health
- Chronic Myeloid Leukemia Treatments
- Hemophilia Treatment and Research
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2016-2025
West China Hospital of Sichuan University
2016-2024
Sichuan Cancer Hospital
2022-2023
South China Institute of Collaborative Innovation
2021
Ludwig Cancer Research
2020
University of Oxford
2020
Guangdong Academy of Medical Sciences
2017
Guangdong General Hospital
2017
Jacobson Holman (United States)
2015
Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic conducted 1868 Chinese cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional...
The gastric microbial community plays a fundamental role in cancer (GC), and the two main anatomical subtypes of GC, non-cardia cardia are associated with different risk factors (
Primary gastric lymphoma (PGL) is the most common extranodal non-Hodgkin lymphoma. This retrospective study aimed to analyze clinical characteristics, prognostic factors, and roles of different treatment modalities in patients with PGL. From January 2003 November 2014, 165 who were diagnosed PGL at West China Hospital enrolled this study. The features, treatment, follow-up information analyzed. In study, diffuse large B-cell (DLBCL) (108, 65.5%) mucosa-associated lymphoid tissue (MALT) (52,...
Abstract Background Due to the controversy over prognostic significance of Borrmann type in patients with gastric cancer (GC), present study was investigate clinical value advanced GC. Methods We retrospectively evaluated 2092 GC and subsequently examined clinicopathological characteristics prognosis stratified by type. Results Patients were divided into three groups according (Borrmann types I+II, III, IV). III IV had larger size, more poorly differentiated tumor type, stage, higher chance...
Abstract Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase more than a billion in less 20 years, which associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs characterized by insulin resistance, high glucose levels, adipocyte dysfunction, are related senescence. Although this cellular aging has beneficial biological functions, it...
// Xiao-Long Chen 1, 2, * , Xin-Zu Yi-Gao Wang Du He 3 Zheng-Hao Lu 2 Kai Liu Wei-Han Zhang Wei Chang-Chun Li Lian Xue Lin-Yong Zhao Kun Yang Jian-Ping Zong-Guang Zhou 4 Jian-Kun Hu Xian-Ming Mo 5 1 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Laboratory Gastric Cancer, State Key Biotherapy/Collaborative Innovation Center Biotherapy and Cancer Center, Pathology, Institute Digestive Stem Cell Biology, These authors have contributed equally...
This study aimed to evaluate the prognostic significance of node ratio (Nr), metastatic retrieved lymph nodes, and investigate whether a modified staging system based on Nr can improve ability for gastric cancer patients following gastrectomy. A total 2572 were randomly divided into training set validation set, cutoff points produced using X-tile. The relationships between other clinicopathologic factors analyzed, while survival discriminatory accuracy compared among different systems by AIC...
The clinical prognostic significance of tumor size (Ts) in gastric cancer remains under debate. This study aims to evaluate the value Ts patients undergoing gastrectomy. A total 2405 with cancer, all having received radical resection, were enrolled this retrospective from 2000 2011. Patients categorized by minimum P log-rank χ2 statistics using X-tile. relationships between and other clinicopathologic characteristics analyzed, survival prediction accuracy was also compared T stage. divided...
The results of studies comparing Billroth-I (B-I) with Roux-en-Y (R-Y) reconstruction on the quality life (QoL) are still inconsistent. aim this trial was to compare long-term QoL B-I R-Y anastomosis after curative distal gastrectomy for gastric cancer.A total 140 patients undergoing D2 lymphadenectomy in West China Hospital, Sichuan University from May 2011 2014 were randomly assigned group ( N = 70) and 70). follow-up time points 1, 3, 6, 9, 12, 24, 36, 48, 60 months operation. final 2019....
Various factors may affect the clinical prognosis of lymph node-negative gastric cancer (GC) patients. This study aimed to provide evaluable prognostic information combination tumor size (Ts), nodes count (LNs) and lymphovascular invasion (LVI) in GC patients.A total 1,019 patients were enrolled this retrospective from 2000 2010. The cutoff points Ts LNs determined using X-tile randomly categorized into training validation sets by sample ratio 1:1. clinicopathologic characteristics analyzed...
Laparoscopy-assisted distal gastrectomy (LADG) is widely used for gastric cancer (GC) patients nowadays. This study aimed to investigate the time trend of outcomes so as describe learning curve GC with LADG at a single medical institution in western China over 6-year period. A total 246 consecutive were divided into 5 groups (group A: 46 from 2006 2007; group B: 47 2008; C: 49 2009; D: 73 2010; and E: 31 2011). All surgeries conducted by same surgeon. Comparative analyses successively...