A5075920939- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Viral Infections and Immunology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
- Immune responses and vaccinations
- Animal Virus Infections Studies
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
Children's Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
China International Science and Technology Cooperation
2016-2025
Chongqing Maternal and Child Health Hospital
2024
Xiamen University
2024
Beijing Children’s Hospital
2024
Capital Medical University
2024
National Clinical Research
2019-2023
Jiangxi University of Traditional Chinese Medicine
2023
Shanghai Children's Medical Center
2022
Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV have been associated with chronic wheezing asthma during childhood. However, mechanism RSV-induced airway inflammation hyperresponsiveness (AHR) poorly understood. Furthermore, there are presently neither effective vaccines nor drugs available for prevention or treatment infections. In this study, we investigated effect plant extract resveratrol as a means...
Abstract The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration human umbilical cord-mesenchymal (UC-MSCs) significantly improved survival attenuated the inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used proteins-chip bioinformatics to analyze interactions between UC-MSCs treatment immune-response...
Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results phase 2 trial suggested that ziresovir may have efficacy the treatment infants hospitalized RSV infection.
Abstract Background: The objective of this study was to determine the efficacy and safety nebulized 3% hypertonic saline solution salbutamol in treatment mild moderate bronchiolitis. Methods: In a randomized controlled trial, 93 infants with bronchiolitis were divided into two groups. received inhalation 2.5 mg (0.5 mL) dissolved either 4.0 mL normal (0.9%) (control group, n = 43) or (3%) (treatment 50). therapy repeated three times daily until discharge. Cough, wheezing, pulmonary physical...
Background Human adenovirus 55 ( HA dV‐55) has caused recent outbreaks of acute respiratory disease ARD ) among adults and military trainees. The active surveillance for dV infections was sparse in China, current knowledge on the dV‐type distributions its molecular evolution is lacking. Objectives To acquire better understanding prevalence dV‐55 strains an informed strategy control prevention. Population/Methods Nasopharyngeal aspirates were collected from hospitalized children with ARTI...
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and leading infant hospitalization worldwide. Uncontrolled response to RSV mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activity an inhibitor TRIF/TBK1/IRF-3 complex. We hypothesize that resveratrol inhibits TRIF-dependent pathway through upregulation SARM post-RSV infection. BALB/c mice were infected with injected 1 h...
Multinational studies have reported that the implementation of nonpharmaceutical interventions (NPIs) to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission coincided with decline other viruses, such as influenza viruses and syncytial virus.To investigate prevalence common during disease 2019 (COVID-19) pandemic.Respiratory specimens children lower tract infections (LRTIs) hospitalized at Children's Hospital Chongqing Medical University from January 1, 2018...
ABSTRACT Respiratory syncytial virus (RSV) is the most commonly identified viral agent in young children with acute respiratory tract infections (ARIs) and often causes repeated throughout life. This study investigated genetic variability of attachment (G) protein gene among RSV strains prevalent southwestern China. Reverse transcription-PCR (RT-PCR) for a fragment G was performed nasopharyngeal aspirates (NPAs) collected from ARIs hospitalized Chongqing Children's Hospital, Chongqing, A...
Background Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are available to support its role as an etiologic agent in lower respiratory tract infection (LRTI). The objective of this study assess the impact HBoV viral load on clinical characteristics children who were positive suffered severe LRTI. Methods Lower aspirates from 186 hospitalized with LRTI obtained by bronchoscopy. HBoVs detected real-time PCR other 10 infectious agents examined using and/or...
Atopic dermatitis (AD) is characterized by a defective skin barrier, which increases the penetration of allergens and pathogens through skin. The role interleukin (IL)‑17, pro‑inflammatory cytokine, in pathogenesis AD remains to be elucidated. present study aimed examine effects IL‑17 on barrier proteins HaCaT cell line. expression levels filaggrin (FLG) involucrin (IVL) were evaluated reverse transcription‑quantitative polymerase chain reaction western blot analyses cells following...
Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease in premature newborns, with high morbidity and mortality rates. Mesenchymal stem cell (MSC) transplantation has developed into promising approach to alleviate BPD. Small extracellular vesicles, which are an important therapeutic component of MSCs, have been reported be effective mouse model However, the affected types detailed underlying mechanisms unclear. In this study, we found that human umbilical cord mesenchymal...
Dendritic cells are critical for the induction of both primary immune responses and immunological tolerance, as well regulation T-helper 1 (Th1) 2 (Th2) responses. As neonates notably deficient in Th1 response cord blood transplantation is noted to result less graft-versus-host disease (GvHD), we compared phenotypic functional characteristics monocyte-derived dendritic (DCs) that favour development from adult peripheral understand underlying mechanisms these observations. Our results showed...
Human enterovirus 68 (HEV-68) is an associated with respiratory illness. In China, no information about HEV-68 available for children yet. This study aimed to investigate the presence of in mainland China between 2009 and 2012 explore migration events across world. Among 1565 samples tested from children, 41 (2.6%) were positive HEV 223 (14.3%) human rhinovirus (HRV). Seven (17.1%) HEVs HEV-68. Two HEV-68- five HRV-positive detected 585 adult samples. predominant type acute tract infection...
Human bocavirus is a newly discovered parvovirus. Multiple studies have confirmed the presence of human bocavirus1 (HBoV1) in respiratory tract samples children. The viral load, presentation single detection and its role as causative agent severe infections not been thoroughly elucidated. We investigated HBoV1 by quantitative polymerase chain reaction (PCR) nasopharyngeal aspirate specimens from 1229 children hospitalized for infections. were analyzed 15 viruses PCR 7 culture. At least one...
Acute respiratory infections (ARIs) cause large disease burden each year. The codetection of viral and bacterial pathogens is quite common; however, the significance for clinical severity remains controversial. We aimed to identify viruses bacteria in hospitalized children with ARI impact mixed detections. Hospitalized aged ≤16 were recruited from 2009 2013 at Children's Hospital Chongqing Medical University, Chongqing, China. Nasopharyngeal aspirates (NPAs) collected detection common by...
Abstract Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause ST respiratory tract infection (RTI) children. Nasopharyngeal aspirate samples were collected and assessed for common viruses. relationships between virus infections secondary analyzed retrospectively. blood platelet count the presence viruses determined 3156 RTI patients 817 (25.9%) cases ≥500 × 10 9 /L considered as group. Compared normal group, detection rates...
Viral diarrhea is one of the leading causes morbidity and mortality in children. This study was conducted to disclose etiological cause epidemiological features viral among children China. From 2009 2021, active surveillance performed on pediatric patients with acute tested for five enteric viruses. Positive detection determined 65.56% (3325/5072) an age-specific infection pattern observed. A significantly higher positive rate observed 12-23-month-old rotavirus (47.46%) adenovirus (7.06%),...
Respiratory syncytial virus (RSV) is one of the most common causes lower respiratory tract infections (LRTI). However, only limited information available regarding its seasonality and relationship with birth month. A retrospective hospital-based study was carried out from June 2009 to May 2019 in Chongqing, southwest China. LRTI cases under 5 years were enrolled this PCR used detect 8 viruses. RSV determined using "average annual percentage" (AAP) "percent positivity" method. total 6991...