A5101426886- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Coronary Interventions and Diagnostics
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Mesenchymal stem cell research
- Bacterial Infections and Vaccines
- Acute Myocardial Infarction Research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Fatty Acid Research and Health
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal and GI Pathology
- Streptococcal Infections and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Transplantation: Methods and Outcomes
Harbin Medical University
2017-2025
Second Affiliated Hospital of Harbin Medical University
2017-2025
Yixing People's Hospital
2025
Jiangsu University
2025
Chongqing Medical University
2014-2023
Children's Hospital of Chongqing Medical University
2014-2023
China International Science and Technology Cooperation
2017-2023
Ministry of Education of the People's Republic of China
2022
National Clinical Research
2019-2020
Chinese National Human Genome Center
2013
Abstract The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration human umbilical cord-mesenchymal (UC-MSCs) significantly improved survival attenuated the inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used proteins-chip bioinformatics to analyze interactions between UC-MSCs treatment immune-response...
Previous studies have reported the value of quantitative flow ratio (QFR) to assess physiological significance non-culprit lesions (NCLs) in acute myocardial infarction (AMI) patients and optical coherence tomography (OCT)-defined thin-cap fibroatheroma (TCFA) identify vulnerable plaques. We sought systematically compare long-term NCL-related clinical prognosis an AMI population utilising Murray fractal law-based QFR (μQFR) values OCT-defined TCFA. Three-vessel OCT imaging μQFR assessment...
Background The FAVOR III (Comparison of Quantitative Flow Ratio Guided and Angiography Percutaneous Intervention in Patients With Coronary Artery Disease) China trial reported improved clinical outcomes with percutaneous coronary intervention guided by quantitative flow ratio (QFR) compared angiography. Whether these benefits also apply for patients presenting “uncertainty‐zone” lesions intermediate physiological significance is uncertain. This study aims to examine the impact QFR guidance...
Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease in premature newborns, with high morbidity and mortality rates. Mesenchymal stem cell (MSC) transplantation has developed into promising approach to alleviate BPD. Small extracellular vesicles, which are an important therapeutic component of MSCs, have been reported be effective mouse model However, the affected types detailed underlying mechanisms unclear. In this study, we found that human umbilical cord mesenchymal...
In December 2019, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbroke in Wuhan, the capital city of Hubei province, China. The disease rapidly spread to other areas China due a huge population movement during New Year Festival. Here, 7-year-old child with SARS-CoV-2 infection Chongqing, outside was reported. This case suggested that children infected are more likely present milder manifestations than adults. continuous positive real-time reverse...
Background Glucocorticoids (GCs) are a first-line treatment for asthma their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury. The protein GC-induced leucine zipper (GILZ) is reported to inhibit activation mitogen-activated kinase (MAPK)-extracellular-signal-regulated (ERK) signaling pathway, which promotes cells around damaged areas. We investigated whether inhibition imposed by GC dexamethasone (DEX) mediated GILZ. Methods tested effect DEX on...
This study aimed to develop and validate a simple-to-use nomogram for predicting refractory Mycoplasma pneumoniae pneumonia (RMPP) in children.A total of 73 children with RMPP 146 general were included. Clinical, laboratory, radiological data obtained. A least absolute shrinkage selection operator (LASSO) regression model was used determine optimal predictors. The plotted by multivariable logistic regression. performance the assessed calibration, discrimination, clinical utility.The LASSO...
Abstract To investigate and analyze the relevant risk factors for bronchiolitis obliterans (BO) in children with severe adenovirus pneumonia, a retrospective study of pneumonia was performed 34 cases that developing BO 105 not Children's hospital Chongqing Medical University from January 2015 to February 2019. The multivariate logistic regression analysis used identify which were significantly associated development after univariate analysis, receiver operating characteristic (ROC) curve...
Patients with acute myocardial infarction and angiographically obstructive non-culprit lesions are at high risk for recurrent major adverse cardiac events (MACEs). However, it remains largely unknown whether due to stenosis severity or the underlying high-risk lesion morphology. Between January 2017 December 2021, 1312 patients underwent optical coherence tomography of all 3 main epicardial arteries after successful percutaneous coronary intervention. were categorized according presence...
This article analyzed the use of veno-arterio-venous extracorporeal membrane oxygenation (VAV-ECMO) in treatment a patient with severe cardiopulmonary insufficiency caused by inhalation dilute nitric acid liquid and aerosol. Combined relevant literature, pathogenesis was discussed experience summarized. The large amount aerosol chemical pneumonia patient, which resulted cardiac due to dysregulation ventricular artery coupling. After administration VAV-ECMO, well-oxygenated blood effectively...
Abstract Background Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors and one of the most common chronic diseases. It has poor prognosis, especially in preterm infants. However, effective therapies for this disease are lacking. Stem-cell therapy promising way improve injury abnormal alveolarization, human umbilical cord (hUC) good source mesenchymal stem cells (MSCs), which have demonstrated efficacy other We hypothesized that intravenously...
Scalable and efficient production of high-quality recombinant adeno-associated virus (rAAV) for gene therapy remains a challenge despite recent clinical successes. We developed new strategy scalable rAAV by sequestering the AAV helper genes vector DNA in two different subcellular compartments, made possible using cytoplasmic vaccinia as carrier genes. For first time, contamination replication-competent particles (rcAAV) can be completely eliminated theory avoiding ubiquitous nonhomologous...
Summary Background The effects of glucocorticoids ( GC s) on the repair airway epithelium in asthma are controversial, and we previously reported that dexamethasone (Dex) inhibits human epithelial cells this process is mediated by glucocorticoid‐induced leucine zipper GILZ ) through MAPK ‐ ERK signaling vitro . Vitamin A VA involved regulation pathway but has not been widely supplied during treatment. It unclear whether attenuates negative maintains integrity Methods Female BALB /c mice were...
Background/Aims: Previous studies have shown that lipopolysaccharide (LPS) exposure may a protective effect on asthma by reducing airway hyper-responsiveness, inflammation and serum IgE levels. However, there are few investigating the of LPS mucous secretion in asthma. In this study, we evaluate relationship between pre-treatment infant mice mucus hypersecretion an OVA (ovalbumin)-induced model, further explore mechanisms behind effect. Methods: Mice were pre-treated with intranasal...