A5071979333- Sphingolipid Metabolism and Signaling
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Oral microbiology and periodontitis research
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Polyomavirus and related diseases
- NF-κB Signaling Pathways
- Animal Virus Infections Studies
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Coronary Interventions and Diagnostics
- Bacterial biofilms and quorum sensing
- Pediatric Hepatobiliary Diseases and Treatments
- Probiotics and Fermented Foods
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Ocular Oncology and Treatments
- Pancreatic function and diabetes
Harbin Medical University
2025
Henan Agricultural University
2025
Chongqing Medical University
2024
Harvard University
2022-2024
Dana-Farber Cancer Institute
2022-2024
Changhai Hospital
2023-2024
Second Military Medical University
2023-2024
Beijing Children’s Hospital
2022-2024
Capital Medical University
2022-2024
Wayne State University
2013-2024
Abstract Single-stranded circular RNAs (circRNAs), generated through ‘backsplicing’, occur more extensively than initially anticipated. The possible functions of the vast majority circRNAs remain unknown. Virus-derived have recently been described in gamma-herpesviruses. We report that oncogenic human papillomaviruses (HPVs) generate circRNAs, some which encompass E7 oncogene (circE7). HPV16 circE7 is detectable by both inverse RT-PCR and northern blotting HPV16-transformed cells. CircE7 N 6...
Hematopoietic stem cells (HSCs) have a number of unique physiologic adaptations that enable lifelong maintenance blood cell production, including highly regulated rate protein synthesis. Yet, the precise vulnerabilities arise from such not been fully characterized. Here, inspired by bone marrow failure disorder due to loss histone deubiquitinase MYSM1, characterized selectively disadvantaged HSCs, we show how reduced synthesis in HSCs results increased ferroptosis. HSC can be rescued...
Mammalian biological processes such as inflammation, involve regulation of hundreds genes controlling onset and termination. MicroRNAs (miRNAs) can translationally repress target mRNAs regulate innate immune responses. Our model system comprised primary human keratinocytes, which exhibited robust differences in inflammatory cytokine production (interleukin-6 tumor necrosis factor-alpha) following specific Toll-like receptor 2 4 (TLR-2/TLR-4) agonist challenge. We challenged these cells with...
Previous studies have reported the value of quantitative flow ratio (QFR) to assess physiological significance non-culprit lesions (NCLs) in acute myocardial infarction (AMI) patients and optical coherence tomography (OCT)-defined thin-cap fibroatheroma (TCFA) identify vulnerable plaques. We sought systematically compare long-term NCL-related clinical prognosis an AMI population utilising Murray fractal law-based QFR (μQFR) values OCT-defined TCFA. Three-vessel OCT imaging μQFR assessment...
ABSTRACT Periodontitis is a chronic human inflammatory disease initiated and sustained by dental plaque microorganisms. A major contributing pathogen Porphyromonas gingivalis , gram-negative bacterium recognized Toll-like receptor 2 (TLR2) TLR4, which are expressed gingival epithelial cells (HGECs). However, it still unclear how these respond to P. initiate immune responses. We have reported previously that HGECs produce wide range of proinflammatory cytokines, including interleukin-6...
Abstract RBM10 is an RNA splicing regulator that frequently mutated in lung adenocarcinoma (LUAD) and has recently been proposed to be a cancer gene. How mutations observed LUAD affect its normal functions, however, remains largely unknown. Here integrative analysis of mutation expression data revealed LUAD-associated exhibit mutational spectrum similar tumor suppressor genes. In addition, this showed identified patients lacking canonical oncogenes are associated with significantly reduced...
The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in macrophages, but whether they have distinct functions remains unclear. We confirmed that expression increased after M1 polarization stimuli found M2 stimulation macrophages. Conditional deletion of Glut3 (LysM-Cre Glut3fl/fl) impaired bone marrow-derived Alternatively activated macrophages from the skin patients with atopic dermatitis showed expression, a calcipotriol-induced model was rescued LysM-Cre...
Despite advances in defining diverse somatic mutations that cause myeloid malignancies, a significant heritable component for these cancers remains largely unexplained. Here, we perform rare variant association studies large population cohort to identify inherited predisposition genes blood cancers. CTR9, which encodes key of the PAF1 transcription elongation complex, is among identified. The risk variants found cases loss function and result ∼10-fold increased odds acquiring malignancy....
Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are frequently observed lung adenocarcinoma (LUAD). We have previously shown that enhances exon skipping of its target genes, including paralog RBM5. Here, we report negatively regulates own mRNA expression RBM5 by promoting alternative splicing-coupled nonsense-mediated decay (AS-NMD). Through computational analysis experimental validation, identified RBM10-promoted 6 or 12 16 as underlying AS-NMD events....
Porphyromonas gingivalis, a Gram-negative oral pathogen, has been shown to induce apoptosis in human gingival epithelial cells, yet the underlining cellular mechanisms controlling this process are poorly understood. We have previously that P. gingivalis proteases arginine and lysine gingipains, necessary sufficient host cell apoptosis. In present study, we demonstrate 'P. gingivalis-induced apoptosis' is mediated through degradation of actin leading cytoskeleton collapse. Stimulation cells...
Rice (Oryza sativa) is one of the most important staple foods for more than half global population. Many rice traits are quantitative, complex and controlled by multiple interacting genes. Thus, a full understanding genetic relationships will be critical to systematically identify genes controlling agronomic traits. We developed genome-wide protein-protein interaction network (RicePPINet, http://netbio.sjtu.edu.cn/riceppinet) using machine learning with structural relationship functional...
This study examined correlates of the vulnerability to fraud among a group urban Chinese older adults, focusing on influence personality traits and loneliness. A non-probability sample 321 participants recruited from six communities in Tianjin, China participated survey. Key measures included Elder Risk for Fraud Scale, short Big Five Inventory, Emotional-Social Loneliness Inventory. Regression analyses found that agreeableness was associated with lower risks while social loneliness higher...
The spoilage microbiology in Paocai (fermented vegetables) affects not only the quality of this popular traditional Chinese food but also its safety. This study aimed to isolate and identify microorganisms commonly leading homemade from Sichuan region and, further, scientifically assess impact these on product Seven putrid samples were collected 7 families different cities. From these, 45 strains isolated by means a nutrient agar medium rose bengal agar. All 22 (5 fungi 17 bacteria) with...
Background Biliary atresia (BA) is the most common cholestatic liver disease in neonates. Herein, we aimed at characterizing gut microbiota and fecal bile acid profiles of BA patients, defining correlations between them, evaluating relationship clinical pathogenesis changes profiles. Methods A total 84 samples from patients (n = 46) matched healthy controls (HCs, n 38) were subjected to sequencing by 16S rRNA gene amplification, analyzed targeted metabolomics. Findings Compared with...
Patients with acute myocardial infarction and angiographically obstructive non-culprit lesions are at high risk for recurrent major adverse cardiac events (MACEs). However, it remains largely unknown whether due to stenosis severity or the underlying high-risk lesion morphology. Between January 2017 December 2021, 1312 patients underwent optical coherence tomography of all 3 main epicardial arteries after successful percutaneous coronary intervention. were categorized according presence...
Colletotrichum graminicola can cause leaf spots and stalk rot in maize. The primary function of carbohydrate esterases (CEs) is to eliminate ester modifications from monosaccharides, oligosaccharides, polysaccharides, thereby facilitating the hydrolysis sugars. We identified 128 CE genes through whole-genome analysis functional annotation C. TZ–3 here. further analyzed physicochemical properties, subcellular localization, conserved motifs, gene structures, promoter regulatory elements these...
Abstract Multiple human polyomaviruses (HPyV) can infect the skin, but only Merkel cell polyomavirus (MCPyV) has been implicated in development of a cancer, carcinoma (MCC). While expression HPyV6, HPyV7, and MCPyV small T antigens (sT), all induced senescence-associated secretory phenotype (SASP), sT uniquely activated noncanonical NF-κB (ncNF-κB), instead canonical signaling, to evade p53-mediated cellular senescence. Through its large stabilization domain, ncNF-κB signaling both by...