A5003240871- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Occupational and environmental lung diseases
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Bone and Dental Protein Studies
- Chronic Lymphocytic Leukemia Research
- Inflammatory Biomarkers in Disease Prognosis
- Protease and Inhibitor Mechanisms
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Sarcoma Diagnosis and Treatment
- Effects of Radiation Exposure
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Cancer Cells and Metastasis
Wayne State University
2011-2024
The Barbara Ann Karmanos Cancer Institute
2011-2024
Harper University Hospital
2002-2022
Michigan United
2013
John D. Dingell VA Medical Center
2005-2013
National Cancer Institute
1990-2007
La Jolla Institute for Immunology
2005
Memorial Sloan Kettering Cancer Center
1996-2001
Universidad Nacional de Asunción
1996
National Institutes of Health
1990-1992
We investigated the presence of osteopontin in pleural mesothelioma and determined serum levels three populations: subjects without cancer who were exposed to asbestos, not patients with asbestos.A group 69 asbestos-related nonmalignant pulmonary disease compared 45 exposure asbestos 76 surgically staged mesothelioma. Tumor tissue was examined for by immunohistochemical analysis, measured an enzyme-linked immunosorbent assay.There no significant differences mean (+/-SE) between age-matched...
Abstract Purpose: As an approach to evaluate the expression pattern and status of activation signaling pathways in clinical specimens from head neck squamous cell carcinoma (HNSCC) patients, we established Head Neck Cancer Tissue Array Initiative, international consortium aimed at developing a high-density HNSCC tissue microarray, with high representation oral carcinoma. Experimental Design: These arrays were constructed by acquiring cylindrical biopsies multiple individual tumor tissues...
Abstract Purpose: A role for estrogens in determining lung cancer risk and prognosis is suggested by reported sex differences susceptibility survival. Archival tissue was evaluated the presence of nuclear estrogen receptor (ER)-α ER-β relationship between ER status, subject characteristics, Experimental Design: Paraffin-embedded tumor samples were obtained from 214 women 64 men two population-based, case-control studies as 10 normal autopsy patients without cancer. Nuclear ER-α expression...
Background: Telomerase enzyme activity is not detected in most normal cells, a phenomenon believed to be associated with limitations on cellular proliferation. Since this nearly all human tumors, including non-small-cell lung cancers, it has been suggested that telomerase activation may coupled acquisition of the malignant phenotype. In study, we determined whether was tumor pathologic stage, cell proliferation rates, and clinical outcome cohort patients resected cancer for whom long-term...
Purpose Estrogen receptor (ER) expression in lung tumors suggests that estrogens may play a role the development of cancer. We evaluated hormone-related factors determining risk non–small-cell cancer (NSCLC) women. also whether were differentially associated with cytoplasmic ER-α and/or nuclear ER-β expression–defined NSCLC postmenopausal Patients and Methods Population-based participants included women aged 18 to 74 years diagnosed metropolitan Detroit between November 1, 2001 October 31,...
Synovial sarcoma is characterized by a specific recurrent translocation t(X; 18), resulting in either the SYT-SSX1 or SYT-SSX2 gene fusion. Because this primary genetic alteration these tumors, we sought to identify impact of molecular heterogeneity t(X;18) on cell proliferation, apoptosis, and epithelial differentiation synovial sarcoma. Seventy-three patients with (18 biphasic, 55 monophasic) were selected basis availability tumor material for immunohistochemical analysis. Tumors...
Unknown primary head and neck squamous cell carcinoma (HNSCC) presents as a cervical lymph node metastasis without identification of the tumor, despite thorough diagnostic work-up that includes physical examination, computed tomography, esophagoscopy, laryngoscopy, bronchoscopy, multiple surveillance biopsies. We investigated whether site origin tumor could be localized in upper aerodigestive tract mucosa by detection genetic alterations identical to those found metastatic...
BACKGROUND Alterations of the p53 gene and MDM2, a coding for binding protein, have been implicated in pathogenesis osteosarcoma (OS). METHODS To determine frequency alterations p53/MDM2 pathway OS their possible correlation with clinicopathologic features, MDM2 copy number protein levels were determined series 83 samples by quantitative Southern blot analysis immunohistochemistry, respectively. RESULTS Positivity was found 26.5% amplification 6.6% analyzed mutually exclusive fashion one...
Aims: Differentiating sarcomatoid mesothelioma from other pleural‐based spindle cell tumours by light microscopy can be challenging, especially in a biopsy. The role of immunohistochemistry this differential diagnosis is not as well defined it for distinguishing epithelioid adenocarcinoma. In study, we investigate the utility diagnostic its histological mimics, high‐grade sarcoma and pulmonary carcinoma. Methods: We stained 20 mesotheliomas with components (10 biphasic 10 mesotheliomas)...
Abstract Purpose: Clinical outcomes for malignant pleural mesothelioma (MPM) patients having surgery are imprecisely predicted by histopathology and intraoperative staging. We hypothesized that gene expression profiles could predict time to progression survival in surgically cytoreduced of all stages. Experimental Design: Gene analyses from 21 MPM cytoreductions identical postoperative adjuvant therapy were performed using the U95 Affymetrix chip. Using both dChip SAM, neural networks...
The INK4A gene, localized to human chromosome 9p21, encodes p16INK4A, a tumor suppressor that functions at least in part through the inhibition of CDK4, cyclin-dependent kinase encoded by gene 12q13. To examine alterations uncultured samples osteosarcoma and relationship between CDK4 alterations, we analyzed genes 87 specimens from 79 patients. deletion amplification were determined quantitative Southern blot analysis. exon 2 was screened for mutation polymerase chain reaction single-strand...
Retinoids (derivatives of vitamin A) are reported to reduce the occurrence some second primary cancers, including aerodigestive tract tumors. In contrast, beta-carotene does not cancers. Mechanisms explaining these effective retinoid and ineffective carotenoid chemoprevention results poorly defined. Recently, all-trans-retinoic acid (RA)-induced proteolysis cyclin D1 that leads arrest cells in G1 phase cell cycle was described human bronchial epithelial is a promising candidate for such...
Abstract Objectives: The objectives of the study were to detect human papillomavirus (HPV) sequences in nasal inverted papilloma (IP) lesions and determine whether HPV is involved progression IP sinonasal squamous cell carcinoma (SCC). Study Design: A retrospective was performed on 14 patients diagnosed with within last 12 years. Three these developed SCC. Methods: Eighteen formalin‐fixed, paraffin‐embedded tissue blocks obtained for patients. After DNA extraction, polymerase chain reaction...
Abstract Currently, no effective tool exists for screening or early diagnosis of head and neck squamous cell carcinoma (HNSCC). Here, we describe an approach cancer detection based on analysis patterns serum immunoreactivity against a panel biomarkers selected using microarray-based serologic profiling specialized bioinformatics. We biopanned phage display libraries derived from three different HNSCC tissues to generate 5,133 selectively cloned tumor antigens. Based their differential...
<h3>Objective</h3> To assess the feasibility of treating patients with high-risk stage III and IV squamous cell carcinoma oral cavity, oropharynx, hypopharynx, larynx perioperative adenovirus-p53 (INGN 201) gene therapy along surgery chemoradiotherapy. <h3>Design Setting</h3> A phase 2 study in a multi-institutional setting within Southwest Oncology Group. <h3>Patients</h3> Thirteen individuals who met following entry criteria: newly diagnosed, previously untreated larynx, or hypopharynx;...
The erbB-2 gene product, gp185erbB-2, displays a potent transforming effect when overexpressed in NIH 3T3 cells. In addition, it possesses constitutively high levels of tyrosine kinase activity the absence exogenously added ligand. this study, we demonstrate that its carboxy-terminal domain exerts an enhancing on and activities. A premature termination mutant protein, lacking entire (erbB-2 delta 1050), showed 40-fold reduction ability lowered vivo for intracellular substrates. When was...