Judith Abrams
A5016774003- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Oral health in cancer treatment
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- T-cell and Retrovirus Studies
- Estrogen and related hormone effects
- Phytoestrogen effects and research
- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
Critical Path Institute
2024
Buckinghamshire Healthcare NHS Trust
2024
Wayne State University
2013-2023
The Barbara Ann Karmanos Cancer Institute
2014-2023
Core Laboratories (United States)
2012
Georgetown University
2011
Biomedical Research Institute
2011
Fred Hutch Cancer Center
2011
Cancer Research Center
2011
Stony Brook University
2011
BackgroundMany patients with COVID-19 have been treated plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent therapy in admitted hospital COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation Therapy [RECOVERY]) is assessing several possible treatments hospitalised UK. The underway at 177 NHS hospitals from across Eligible consenting were randomly assigned (1:1) receive either usual care alone...
BackgroundAspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate efficacy and safety aspirin in patients admitted hospital with COVID-19.MethodsIn this randomised, controlled, open-label, platform trial, several possible treatments were compared usual care hospitalised COVID-19. The trial took place at 177 hospitals UK, two Indonesia, Nepal. Eligible consenting adults randomly allocated 1:1 ratio either standard plus 150 mg...
In the past, colloid (mucinous noncystic) carcinoma (CC) of pancreas had been included under category ordinary ductal adenocarcinoma, a tumor with dismal prognosis, or was frequently misdiagnosed as mucinous cystadenocarcinoma. The clinicopathologic features CC have not yet well characterized, because most cases on record parts studies either cystic neoplasms (MCN) intraductal papillary (IPMN), which carcinomas are associated. To determine characteristics CC, 17 pancreatic tumors composed...
Abstract A noninvasive screening test would significantly facilitate early detection of epithelial ovarian cancer. This study used a combination high-throughput selection and array-based serologic many antigens indicative the presence cancer, thereby using immune system as biosensor. involved biopanning an cancer phage display library serum immunoglobulins from patient bait. Protein macroarrays containing 480 these selected antigen clones revealed 65 that interacted with in sera 32 patients...
The purpose of this study was to examine the state smartphone applications for cancer intended general public with a focus on interactive features, content sources, and application developer affiliations. level health provider involvement in screening or appraising also assessed.A total 123 apps were identified analysis from two major mobile marketplaces (Apple iTunes = 40; Google Play 83). Application characteristics collected, analyzed, reported. These included platform, cost, affiliation,...
To identify features of major salivary gland cancers that are prognostic for disease-free survival.A retrospective study 78 patients with cancer (64 parotid and 14 submandibular gland) who underwent surgery definitive treatment from 1976 to 1996. A select group also received adjuvant radiation (56%) and/or chemotherapy (13%).Clinical pathological risk factors were obtained patients' charts pathology reports. Age, gender, tumor site, T-stage, facial paralysis, histologic neck involvement,...
Emerging evidence indicates that tumor-associated proteolytic remodeling of bone matrix may underlie the capacity tumor cells to colonize and survive in microenvironment. Of particular importance, urokinase-type plasminogen activator (uPA) has been shown correlate with human prostate cancer (PC) metastasis. The importance this protease be related its ability initiate a cascade, leading activation multiple proteases growth factors. Previously, we showed maspin, serine inhibitor, specifically...
Abstract The 8p11-p12 genomic region is amplified in 15% of breast cancers and harbors several candidate oncogenes. However, functional evidence for a transforming role these genes lacking. We identified 21 from this as potential oncogenes based on statistical association between copy number expression. further showed that three (LSM1, BAG4, C8orf4) induce transformed phenotypes when overexpressed MCF-10A cells, overexpression combination influences the growth factor independence phenotype...
Abstract Bone metastasis is very common in advanced prostate cancer. Docetaxel has been shown to improve survival patients with metastatic However, treatment docetaxel associated a certain degree of toxicity. Genistein, derived from soybeans, found inhibit cancer cell growth without We have recently reported that genistein could potentiate the antitumor activity chemotherapeutic agents both vitro and vivo. molecular mechanism this novel effect not fully elucidated. In study, we significantly...
Increasing evidence indicates the significance of platelet-derived growth factor receptor-β (β-PDGFR) signaling in prostate cancer (PCa). Accordingly, preclinical studies suggest potential β-PDGFR as a therapeutic target metastatic PCa. However, ligand responsible for activation PCa was unknown, and recent clinical trials with imatinib mesylate showed limited success due to normal tissue toxicity. Similarly, spite mounting indicating matriptase PCa, little is known about its substrates or...
We previously showed that genistein, the major bioactive component of soy isoflavones, acts as a radiosensitizer and potentiates prostate tumor cell killing by radiation in vitro animal models vivo. However, when given alone vivo, pure genistein promoted increased lymph node metastasis, which was not observed with isoflavone mixture consisting daidzein, glycitein. In this study, we show inhibit growth radiation-induced like genistein. an orthotopic model, combining isoflavones irradiation...
Prostate cancer frequently metastasizes to the bone, and treatment outcome for metastatic prostate has been disappointing so far. Dietary genistein, derived primarily from soy product, proposed be partly responsible low rate of in Asians. Our previous studies have shown that genistein elicits pleiotropic effects on cells, but there are no documenting comprehensive gene expression profiles antitumor dietary human grown bone environment. In this study, we investigated PC3 cells experimental...
Abstract We previously reported that genistein, the bioactive isoflavone of soybeans, acts as a radiosensitizer for prostate cancer. Pretreatment tumor cells with genistein potentiated radiation‐induced killing in vitro and orthotopic models vivo . However, pure promoted increased lymph node metastasis, when administered alone investigated effects soy isoflavones (genistein, daidzein glycitein) pills similar composition are used human interventions but not genistein. Soy inhibited cell...
Purpose To compare the overall survival (OS) of patients with resected stage III melanoma administered active specific immunotherapy and low-dose interferon alfa-2b (IFN-α-2b) OS achieved using high-dose IFN-α-2b. Patients Methods An Ad Hoc Melanoma Working Group 25 investigators treated 604 from April 1997 to January 2003. were stratified by sex number nodes randomly assigned receive either 2 years treatment allogeneic lysates IFN-α-2b (arm 1) or alone for 1 year 2). Active was injected...