Objective To analyze the outcome of 200 patients with gastrointestinal stromal tumor (GIST) who were treated at a single institution and followed up prospectively. Summary Background Data A GIST is visceral sarcoma that arises from tract. Surgical resection mainstay treatment because adjuvant therapy unproven. Methods Two hundred malignant admitted Memorial Hospital during past 16 years. Patient, tumor, variables analyzed to identify patterns recurrence factors predict survival. Results Of...

PURPOSE To identify specific independent adverse clinicopathologic factors for event-free survival in a cohort of consecutively treated patients with extremity soft tissue sarcomas. PATIENTS AND METHODS Prospectively collected data from population 1,041 adult localized (American Joint Committee on Cancer [AJCC] stage IA to IIIB) sarcomas were analyzed. Patients at single institution between 1982 and 1994. Patient, tumor, pathologic analyzed by univariate multivariate techniques prognostic...

PURPOSE This trial was performed to evaluate the impact of adjuvant brachytherapy on local and systemic recurrence rates in patients with soft tissue sarcoma. PATIENTS AND METHODS In a single-institution prospective randomized trial, 164 were intraoperatively receive either (BRT) or no further therapy (no BRT) after complete resection sarcomas extremity superficial trunk. The radiation administered by iridium-192 implant, which delivered 42 45 Gy over 4 6 days. two study groups had...

To report the patterns of disease and postmetastasis survival for patients with pulmonary metastases from soft tissue sarcoma in a large group treated at single institution. Clinical factors that influence are analyzed.For sarcoma, lungs most common site metastatic disease. Although commonly arise primary tumors extremities, they may almost any or histology. date, resection has been only effective therapy sarcoma.From July 1982 to February 1997, 3149 adult were admitted Memorial...

Objective To define the significance of positive microscopic resection margins in a large cohort treated for soft tissue sarcoma. Methods The authors analyzed 2,084 patients with localized primary sarcoma (all anatomic sites) from 1982 to 2000. Clinicopathologic variables studied included tumor site, size, depth, histologic type, grade, and margin status. Treatment other than was not analyzed. Study endpoints local distant recurrence-free disease-specific survival rates, estimated by...

Few published studies have analyzed risk factors for sarcoma-specific death. We developed and internally validated a nomogram that combines the to predict probability of 12-year death using database 2,136 prospectively followed adult patients treated at single institution.Nomogram predictor variables included age diagnosis, tumor size (< or = 5, 5 10, > 10 cm), histologic grade (high low), subtype (fibrosarcoma, leiomyosarcoma, liposarcoma, malignant fibrous histiocytoma, peripheral nerve...

Objective To test the hypothesis that routine intraperitoneal drainage is not required after pancreatic resection. Summary Background Data The use of surgically placed drains has been considered Recent studies have suggested for other major upper abdominal resections, postoperative and may be associated with an increased complication rate. Methods After informed consent, eligible patients peripancreatic tumors were randomized during surgery either to no or closed suction in a standardized...

Despite optimal surgical therapy for patients with dermatofibrosarcoma protuberans (DFSP), some still continue to develop local recurrence. The authors' objective was identify and analyze clinicopathologic factors disease free survival in a large group of who were followed prospectively at single institution.Prospectively collected data pathology slides available review from 159 primary or recurrent DFSP underwent treatment between July 1950 1998. study comprised either the "classic" form...

Objective The purpose of the study was to determine whether early postoperative enteral feeding with an immune-enhancing formula (IEF) decreases morbidity, mortality, and length hospital stay in patients upper gastrointestinal (GI) cancer. Summary Background Data Early IEF has been associated improved outcome trauma critical care patients. Evaluable data documenting reduced complications after major GI surgery for malignancy are limited. Methods Between March 1994 August 1996, 195 a...

About 40 percent of non-Hodgkin's lymphomas are diffuse with a large-cell component (DLLC). Current therapy can induce long-term remission in half the patients DLLC, but more intensive treatment has potential to improve outcome, particularly at high risk for failure. Clinical and cytogenetic markers identify subgroups or low risk. Rearrangement novel candidate proto-oncogene, bcl-6, is possible prognostic indicator DLLC.

Objective To analyze patients with recurrent extremity desmoids, in whom the surgical therapeutic option was either major amputation or observation. Summary Background Data The biology and natural history of desmoid tumors are an enigma. These invade surrounding structures recur locally but do not metastasize. morbidity treating these context their relatively benign is uncertain. Methods Between July 1982 June 1998, authors treated prospectively followed 206 tumors. All underwent...

PURPOSE Retroperitoneal soft tissue sarcomas are rare tumors. Studies characterizing long-term follow-up and patterns of recurrence limited. The purpose this analysis is to identify prognostic factors associated with survival after resection retroperitoneal sarcomas. METHODS Between July 1, 1982, June 30, 1990, 198 adult patients were identified from our prospective sarcoma database carrying the diagnosis who eligible for &gt; or = 5 years follow-up. Of these, 48 (25%) documented be alive...

PURPOSE: Synovial sarcoma is a high-grade tumor that associated with poor prognosis. Previous studies analyzing prognostic factors are limited because of inclusion heterogeneous cohorts patients nonextremity and recurrent tumors. The objective this study was to determine independent primary synovial localized the extremity. PATIENTS AND METHODS: Between July 1, 1982, June 30, 1996, 112 underwent surgical resection for cure at our institution then were followed-up prospectively. Clinical...

PURPOSE The aim of this study was to analyze local recurrence in a large cohort prospectively followed patients with primary extremity soft tissue sarcoma. In particular, we analyzed the correlation subsequent metastasis and disease-specific survival. PATIENTS AND METHODS Patients who underwent treatment for sarcoma from July 1982 through 1995 at Memorial Sloan-Kettering Cancer Center were subject study. Local recurrence, distant metastasis, survival used as end points influence on examined...

BACKGROUND The natural history of desmoid tumors remains an enigma. Previous reports attempting to identify their biology have included recurrent and primary as well from both intra- extra-abdominal sites. purpose this study was analyze patients with extremity trunk treated followed at a single institution determine factors influencing disease free survival. METHODS Between July 1982 June 1997, 189 superficial were prospectively. Of these, 105 presented formed the basis study. RESULTS median...

Objective To determine whether reresection affects survival in patients with inadequately resected, primary extremity soft tissue sarcoma. This study correlates local recurrence-free survival, metastasis-free and disease-free survival. Summary Background Data Soft sarcomas are rare neoplasms, an incidence of approximately 6,000 per year the United States. Because these tumors benign common, many initially thought to be excised without wide margins. Methods Patients who underwent treatment...

To define prognostic factors for postrelapse survival and their time-dependent influence adult soft tissue sarcoma (STS).We analyzed 2,123 patients with completely resected localized primary STS treated from 1982 to 1999. Variables studied included tumor site, size, depth, grade, resection margin but not treatment other than resection. Landmark time frames were used assess the of disease-free interval (DFI) on disease-specific (DSS). DSS was estimated Kaplan-Meier method. Univariate...

Background Identification of patients vulnerable for atrial fibrillation (AF) after major thoracic surgery will allow targeting those most likely to benefit from prophylactic therapy. The goal the current study was evaluate accuracy easily available clinical characteristics prediction this complication. Methods Patients undergoing elective were chosen an ongoing prospective database. Results Postoperative in-hospital AF occurred in 79 (15%) 527 Using cut-point methodology and logistic...

Hemangiopericytoma (HPC) is a rare vascular tumor, and pathologic distinction from synovial sarcoma solitary fibrous tumor significant problem due to shared histologic features. In the current report authors defined clinical behavior prognosis for patients with HPC.Between July 1982 February 1998, 62 diagnosis of primary, recurrent, or metastatic HPC were identified prospectively maintained database. The pathology all cases which material was available (57 cases) re-reviewed confirmation...

Rhabdomyosarcoma (RMS) in adults (age > or = 16 years) is rare, accounting for less than 3% of adult soft tissue sarcomas. There little information describing the disease biology clinicopathologic factors that influence survival with RMS. The objective this study was to define patients RMS predict outcome, progression, and survival.Eighty-four a pathologic diagnosis confirmed by immunohistochemistry were identified prospective inpatient data base during period 1982--1999 analyzed specific...