A5063642210- Botulinum Toxin and Related Neurological Disorders
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Lymphoma Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Legionella and Acanthamoeba research
- Electromagnetic Fields and Biological Effects
- Pneumonia and Respiratory Infections
- Monoclonal and Polyclonal Antibodies Research
- Effects of Radiation Exposure
- Neurological disorders and treatments
- Hereditary Neurological Disorders
- CNS Lymphoma Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Immunotherapy and Immune Responses
- Reproductive tract infections research
- Carcinogens and Genotoxicity Assessment
- Chronic Lymphocytic Leukemia Research
- Syphilis Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Bacterial biofilms and quorum sensing
- Terahertz technology and applications
- Microbial Inactivation Methods
- Protein Tyrosine Phosphatases
Ministry of Defence
2019-2024
Sapienza University of Rome
2020
University of Bari Aldo Moro
2020
VA Palo Alto Health Care System
2020
Stanford University
2020
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria
2020
Institut für Radiobiologie der Bundeswehr
2020
Bundeswehr Medical Service Academy
2020
Italian Resuscitation Council
2017
Mercy Corps
2016
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6 , codes for a 79-kilodalton protein that homologous with zinc finger-transcription factors. In 33 percent (13 39) DLCL samples, but not other types lymphoid malignancies, truncated within its 5′ noncoding sequences, suggesting expression...
About 40 percent of non-Hodgkin's lymphomas are diffuse with a large-cell component (DLLC). Current therapy can induce long-term remission in half the patients DLLC, but more intensive treatment has potential to improve outcome, particularly at high risk for failure. Clinical and cytogenetic markers identify subgroups or low risk. Rearrangement novel candidate proto-oncogene, bcl-6, is possible prognostic indicator DLLC.
The Metagenomics and Metadesign of the Subways Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised experts across many fields, including genomics, data analysis, engineering, public health, architecture. ultimate goal MetaSUB to improve city utilization planning through detection, measurement, design metagenomics within urban environments. Although continual measures occur for temperature, air pressure, weather, human activity, longitudinal,...
// Laura Masuelli 1 , Enrica Di Stefano Massimo Fantini 2 Rosanna Mattera Monica Benvenuto Marzocchella Pamela Sacchetti Chiara Focaccetti 3 Roberta Bernardini Ilaria Tresoldi Valerio Izzi Maurizio Mattei Giovanni Vanni Frajese 4 Florigio Lista 5 Andrea Modesti and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", STA, Dipartimento di Scienze Motorie, Umane e della Salute, Università Roma, Foro Italico...
Two quality controlled inter-laboratory exercises were organized within the EU project 'Realizing European Network of Biodosimetry (RENEB)' to further optimize dicentric chromosome assay (DCA) and identify needs for training harmonization activities RENEB network.The general study design included blood shipment, sample processing, analysis aberrations radiation dose assessment. After manual scoring chromosomes in different cell numbers estimations corresponding 95% confidence intervals...
During out-of-area military operations, the presence of carcinogenic and/or genotoxic agents has been reported, posing potential health risks to deployed soldiers. Military working dogs (MWDs), trained detect explosives in same environments as soldiers, could also serve sentinel animals, providing valuable information on exposure hazardous agents. These can help identify environmental and adverse effects their that handlers, possibly before relevant pathologies manifest. This study aims...
Endemic presence of Klebsiella pneumoniae resistant to carbapenem in Italy has been due principally the clonal expansion CC258 isolates; however, recent studies suggest an ongoing epidemiological change this geographical area.50 K. strains, 25 carbapenem-resistant (CR-Kp) and susceptible (CS-Kp), collected from march 2014 2016 at Laboratory Bacteriology Paolo Giaccone Polyclinic University hospital Palermo, Italy, were characterized for antibiotic susceptibility fully sequenced by next...
Botulism is a rare but severe neuroparalytic disease caused by botulinum toxins. Because of its high potential impact on public health, botulism closely monitored communicable in Europe. In Italy, which has one the highest incidence rates Europe (0.03 cases per 100,000 population), through case-based passive surveillance system: front-line physician who diagnoses suspected case must notify Local Health Units immediately, and Ministry Health's office within 12 hours. From 1986 to 2015, 466...
Purpose: In the framework of 'Realizing European Network Biodosimetry' (RENEB) project, two intercomparison exercises were conducted to assess suitability an optimized version cytokinesis-block micronucleus assay, and evaluate capacity a large laboratory network performing biodosimetry for radiation emergency triages. Twelve institutions participated in first exercise, four non-RENEB labs added second one.Materials methods: Irradiated blood samples shipped participating labs, whose task was...
The emergence of carbapenem-resistant Klebsiella pneumoniae strains is threatening antimicrobial treatment. Sixty-eight carbapenemase-producing K. isolated at Luigi Sacco University Hospital-ASST Fatebenefratelli (Milan, Italy) between 2012 and 2014 were characterised microbiologically molecularly. They tested for drug susceptibility carbapenemase phenotypes, investigated by means repetitive extra-genic palindromic polymerase chain reaction (REP-PCR), fully sequenced next-generation...
Acinetobacter baumannii exhibits high genomic plasticity, enabling it to acquire virulence factors and antibiotic resistance (AR). Understanding its evolutionary adaptations is crucial for developing effective therapeutic strategies. Thirty clinical isolates collected from two distinct time periods, defined as older (2010-2013), recent (2022-2023),- were compared phenotypically (antibiotic resistance, growth, biofilm formation, desiccation tolerance, invasiveness) genotypically (whole-genome...
The utility of early-phase (≤5 days) radiation-induced clinical signs and symptoms (e.g., vomiting, diarrhea, erythema changes in blood cell counts) was examined for the prediction later occurring acute radiation syndrome (ARS) severity development medical management strategies. Medical treatment protocols accident victims (METREPOL) used to grade ARS severities, which were assigned response categories (RCs). Data on individuals (n = 191) with mild (RC1, n 45), moderate (RC2, 19), severe...
In this paper, we present a dataset of homology-modeled structures SARS-CoV-2 Spike protein Receptor Binding Domain (RBD) variants complexed with antigen-binding fragments (Fab) derived from the PDB 8GPY (Omicron BA.4/5 RBD in complex neutralizing antibody scFv), 8H7Z (BA.2 BA7535 Fab), and 8XE9 (XBB.1.5 BD55-1205). The consists six sets generated by combining 14 three different Fab pairs. sequence included are Wild Type, BETA, EPSILON, IOTA, ETA, GAMMA, LAMBDA, KAPPA, BA.2, BA.4, XBB.1.5,...
Although antimicrobial resistance has not yet emerged as an overarching problem for Legionella pneumophila (L. pneumophila) infection, the description of clinical and environmental strains resistant to fluoroquinolones macrolides is a cause concern. This study aimed investigate susceptibility L. human isolates in Italy. A total 204 were tested sensitivity 9 antibiotics using broth microdilution assay (BMD). All typed by sequence-based typing, serogroup 1 (Lp1) monoclonal antibody...
Clostridium botulinum is a taxonomic designation that encompasses broad variety of spore-forming, Gram-positive bacteria producing the neurotoxin (BoNT). C. etiologic agent botulism, rare but severe neuroparalytic disease. Fine-resolution genetic characterization isolates any BoNT type relevant for both epidemiological studies and forensic microbiology. A 10-locus multiple-locus variable-number tandem-repeat analysis (MLVA) was previously applied to A. The present study includes five...