A5108769292- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Mesenchymal stem cell research
- Respiratory Support and Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Bone Metabolism and Diseases
- Subcritical and Supercritical Water Processes
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Asthma and respiratory diseases
- CRISPR and Genetic Engineering
- Bone health and osteoporosis research
- Infectious Diseases and Mycology
- Allergic Rhinitis and Sensitization
- Per- and polyfluoroalkyl substances research
- Thermochemical Biomass Conversion Processes
- AI in cancer detection
- Metabolism, Diabetes, and Cancer
- Dermatology and Skin Diseases
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Biochemical Analysis and Sensing Techniques
- MXene and MAX Phase Materials
- Tracheal and airway disorders
Children's Hospital of Chongqing Medical University
2017-2025
Chongqing Medical University
2017-2025
Qingdao University
2011-2023
China International Science and Technology Cooperation
2017-2022
National Clinical Research
2022
Xi'an Jiaotong University
2022
Abstract The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration human umbilical cord-mesenchymal (UC-MSCs) significantly improved survival attenuated the inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used proteins-chip bioinformatics to analyze interactions between UC-MSCs treatment immune-response...
Pulmonary fibrosis (PF) is a lethal pathological change of fibrotic interstitial lung diseases (ILDs) with abundant fibroblasts proliferation after severely or continually alveolar epithelial cells (AECs) injury. Barely therapies are helpful for PF. Here we use bleomycin intratracheally injection to model PF without human umbilical cord–mesenchymal stem (hUC–MSCs) and/or nintedanib intervention. RNA‐Seq followed real‐time PCR and western blot were used find out the specific possible...
There are an increasing number of patients suffering from fatty liver caused by type 2 diabetes. We intended to study the preventive and therapeutic effect L-carnitine (LC) on nonalcoholic disease (NAFLD) in streptozotocin (STZ)-induced diabetic mice explore its possible mechanism.Thirty male Kungming were randomly divided into five groups: control group, pre-treatment group (125 mg/kg BW), low-dose BW) high-dose (250 group. The morphology hepatocytes was observed light electron microscopy....
Abstract Background Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors and one of the most common chronic diseases. It has poor prognosis, especially in preterm infants. However, effective therapies for this disease are lacking. Stem-cell therapy promising way improve injury abnormal alveolarization, human umbilical cord (hUC) good source mesenchymal stem cells (MSCs), which have demonstrated efficacy other We hypothesized that intravenously...
Atopic dermatitis (AD) in early childhood is often the initial manifestation of allergic disease associated with high IgE. Accumulating evidences show that follicular helper T (Tfh) cells play a critical role promoting B cell differentiation and IgE production, human regulatory (Breg) participate immunomodulatory processes inhibition inflammation. However, roles interactions between IL-10-producing Breg Tfh AD are unclear. In this study, we found percentage CD19 + IL-10 children extrinsic...
Alveolar epithelial cells (AECs) injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding subsequent pulmonary fibrosis (PF). Nevertheless, exact mechanisms regulating regeneration post-injury still remain unclear. SMARCA4 is a part large ATP-dependent chromatin remodelling complex SWI/SNF, which essential for kidney heart fibrosis. We investigates function in lung by establishing PF mice model with bleomycin firstly found that expression was mainly...
Severe bronchopulmonary dysplasia (BPD) is a chronic lung disorder that primarily affects premature babies with extremely low birth weight and involves in multiple organ system; no effective pharmacotherapy for this disease exists, mortality remains high. Based on the evidence from previous preclinical studies phase I clinical trials, study aims to test safety of intravenous application single dose human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) patients severe BPD. The...
Collagen peptides (CP) have been shown to protect against osteoporosis. Yet, its mechanism on anti-osteoporosis remains unclear. Cell viability, levels of alkaline phosphatase (ALP), reactive oxygen species (ROS), malondialdehyde (MDA) and superoxide dismutase (SOD) hydrogen peroxide (H2O2)-induced oxidative stress in Saos-2 cells pretreated with CP were examined. The effect regulatory FBXW7-p100-NF-κB axis the relationship between molecules explored by overexpressing FBXW7, silencing p100...
Abstract Background : Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors, and one of the most common chronic diseases with poor prognosis, especially in preterm infants severe BPD. However, there lack effective therapies for this disease. Stem cell therapy has been shown promising way improving injury abnormal alveolarization, human umbilical cord (hUC) good resource mesenchymal stem cells (MSCs), which have demonstrated some other diseases....
Abstract Background Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors, and one of the most common chronic diseases with poor prognosis, especially in preterm infants moderate severe BPD. However, there lack effective therapies for this disease. Stem cell therapy has been shown promising way improving injury abnormal alveolarization, human umbilical cord (hUC) good resource mesenchymal stem cells (MSCs), which have demonstrated some other...
Abstract Background: Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors and one of the most common chronic diseases with poor prognosis, especially in preterm infants. However, effective therapies for this disease are lacking. Stem cell therapy promising way improve injury abnormal alveolarization, human umbilical cord (hUC) good source mesenchymal stem cells (MSCs), which have demonstrated efficacy other diseases. We hypothesized that...
Abstract Background: Bronchopulmonary dysplasia (BPD) is a complex lung pathological lesion secondary to multiple factors and one of the most common chronic diseases with poor prognosis, especially in preterm infants. However, effective therapies for this disease are lacking. Stem cell therapy promising way improve injury abnormal alveolarization, human umbilical cord (hUC) good source mesenchymal stem cells (MSCs), which have demonstrated efficacy other diseases. We hypothesized that...