A5111009801- Respiratory viral infections research
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Venous Thromboembolism Diagnosis and Management
- Airway Management and Intubation Techniques
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammation biomarkers and pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biosensors and Analytical Detection
- Blood Coagulation and Thrombosis Mechanisms
- Plant Growth Enhancement Techniques
- Protein Degradation and Inhibitors
- Vitamin C and Antioxidants Research
- Polymer-Based Agricultural Enhancements
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 detection and testing
- Pesticide and Herbicide Environmental Studies
- Bacterial biofilms and quorum sensing
- Pharmaceutical studies and practices
Anhui Agricultural University
2025
Xiangya Hospital Central South University
2024-2025
Central South University
2024-2025
Chongqing Medical University
2012-2024
Children's Hospital of Chongqing Medical University
2012-2024
Quzhou City People's Hospital
2023
China International Science and Technology Cooperation
2019
Boston Children's Hospital
2009
Abstract Background: The objective of this study was to determine the efficacy and safety nebulized 3% hypertonic saline solution salbutamol in treatment mild moderate bronchiolitis. Methods: In a randomized controlled trial, 93 infants with bronchiolitis were divided into two groups. received inhalation 2.5 mg (0.5 mL) dissolved either 4.0 mL normal (0.9%) (control group, n = 43) or (3%) (treatment 50). therapy repeated three times daily until discharge. Cough, wheezing, pulmonary physical...
Objectives To prospectively evaluate prednisolone treatment in children with refractory Mycoplasma pneumonia (MPP). Methods Fifty-eight MPP were enrolled to receive either azithromycin combined (treatment group, n = 28) or alone (control 30). Temperature, respiratory symptoms and signs examined at the time of study entry every 8 hr after enrollment, infiltration absorption, atelectasis resolution, pleural effusion disappearance, serum ferritin LDH levels assessed on seventh day enrollment....
Background Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are available to support its role as an etiologic agent in lower respiratory tract infection (LRTI). The objective of this study assess the impact HBoV viral load on clinical characteristics children who were positive suffered severe LRTI. Methods Lower aspirates from 186 hospitalized with LRTI obtained by bronchoscopy. HBoVs detected real-time PCR other 10 infectious agents examined using and/or...
Human bocavirus is a newly discovered parvovirus. Multiple studies have confirmed the presence of human bocavirus1 (HBoV1) in respiratory tract samples children. The viral load, presentation single detection and its role as causative agent severe infections not been thoroughly elucidated. We investigated HBoV1 by quantitative polymerase chain reaction (PCR) nasopharyngeal aspirate specimens from 1229 children hospitalized for infections. were analyzed 15 viruses PCR 7 culture. At least one...
Abstract Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause ST respiratory tract infection (RTI) children. Nasopharyngeal aspirate samples were collected and assessed for common viruses. relationships between virus infections secondary analyzed retrospectively. blood platelet count the presence viruses determined 3156 RTI patients 817 (25.9%) cases ≥500 × 10 9 /L considered as group. Compared normal group, detection rates...
Respiratory syncytial virus (RSV) is one of the most common causes lower respiratory tract infections (LRTI). However, only limited information available regarding its seasonality and relationship with birth month. A retrospective hospital-based study was carried out from June 2009 to May 2019 in Chongqing, southwest China. LRTI cases under 5 years were enrolled this PCR used detect 8 viruses. RSV determined using "average annual percentage" (AAP) "percent positivity" method. total 6991...
To determine the prevalence of human rhinovirus (HRV) infection in children with acute asthma exacerbations, investigation HRV viral load and severity exacerbations is also required. Nasopharyngeal aspirates swabs were collected assessed for respiratory viruses. HRV-positive samples sequenced to identify types load. Outpatients underwent follow-up evaluations, their clinical outcomes recorded at next clinic visit 4 weeks later. One hundred forty-three inpatients 131 outpatients, including 88...
Streptococcus pneumoniae (pneumococcus) is the most common respiratory pathogen worldwide. Nasopharyngeal carriage with S. major source of lower tract infection and horizontal spread among children. Investigating nasopharyngeal crucial for clinicians to control pneumococcus disease. Here, we retrospectively analyzed clinical information 5,960 hospitalized children, focusing on pneumonia children less than five years positive pneumococcal cultures. aspirates (NPAs) were collected between June...
Abstract BACKGROUND At present, it is vital to develop a stable and efficient pesticide delivery system optimize foliar utilization, which could improve control efficacy, enhance resistance adverse climates, prolong retention. In this study, reaction monomers methylene diphenyl diisocyanate (MDI) polycaprolactone diol (PCL) were used synthesize polymer network structure for loading the organic phase of pesticides in micron‐reactor, then shell was formed by sodium lignosulfonate (SL) didecyl...
Abstract Global pandemics caused by pathogenic viruses have highlighted the need to develop effective and sustainable materials defend against these viruses. However, most commercial viral disinfection rely on precious metals, which are toxic. In this study, an engineered living material based Bacillus subtilis biofilms is presented that can effectively remove Influenza A virus SARS‐CoV‐2 from water. First, B. biofilm used display H1N1 H5N1 specific binding peptide C40 SBP1; thus, has...
Preschool children are at a high risk of developing asthma. Asthma in preschool could remit most cases, but persist into school age, adolescence, or even adulthood some cases. However, it is difficult to predict which with asthma will develop school-age We present cohort study protocol explore the predictive role small airway dysfunction and inflammation biomarkers children.A prospective be conducted least 205 All patients recruited when they consult pediatric pulmonologist Children's...
Endothelial dysfunction is associated with the progression of sepsis. This study sought to probe molecular route sex-determining region on Y chromosome-box transcription factor 18 (SOX18) in sepsis-associated endothelial injury. Human umbilical vein cells (HUVECs) were treated lipopolysaccharide (LPS) establish sepsis cell model. Cell viability, lactate dehydrogenase (LDH) release, oxidative stress (reactive oxygen species/malondialdehyde/superoxide dismutase), and inflammation...
Abstract Pulmonary embolism (PE) leads to obstruction of pulmonary circulation, resulting in increased vascular resistance, elevated arterial pressure, and right heart load. In severe cases, it can lead cardiac decompensation life‐threatening conditions. However, clinical studies on PE children are limited, with many diagnostic treatment guidelines derived from adult populations. We retrospectively analyzed the manifestations, risk factors, co‐morbidity, outcomes patients admitted a large...
Objective To detect the existence of Middle East respiratory syndrome coronavirus (MERS-CoV) in hospitalized children with infection Chongqing area and study clinical symptoms associated detection 4 human coronaviruses (HCoV): HCoV-229E, HCoV-OC43, HCoV-NL63 HCoV-HKU1 types. Methods Nasopharyngeal aspirates collected over a 4-year period (from Jul.2009 to Jun.2013) from pediatric inpatients were analyzed for presence 5 subtypes by using multi-nested polymerase chain reaction sensitive...
NO is an important signal factor existing in expiratory air of normal person.Different kinds airway inflammation can cause the increase NO,especially eosinophilic inflammation.Fractional exhaled nitric oxide(FENO) result inflammation,which noninvasive,repeatable and easily performed.It be very helpful diagnosis differential symptoms such as recurrent wheezing chronic cough.It also help determine state disease prognosis.It a useful tool assessment management diseases,especially asthma. Key...