A5100462424- Insect Resistance and Genetics
- Insect-Plant Interactions and Control
- Entomopathogenic Microorganisms in Pest Control
- Agricultural pest management studies
- Genetic and Environmental Crop Studies
- Legume Nitrogen Fixing Symbiosis
- Renal and related cancers
- Animal Virus Infections Studies
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
- Genetic diversity and population structure
- Virology and Viral Diseases
- Rabies epidemiology and control
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Insect symbiosis and bacterial influences
- Antibiotic Resistance in Bacteria
- Phytochemical compounds biological activities
- Sphingolipid Metabolism and Signaling
- Marine Invertebrate Physiology and Ecology
- Parvovirus B19 Infection Studies
- Lepidoptera: Biology and Taxonomy
- Autoimmune Neurological Disorders and Treatments
Jining First People's Hospital
2025
Leibniz Institute of Plant Genetics and Crop Plant Research
2022-2024
Beijing Children’s Hospital
2024
Capital Medical University
2024
East China University of Science and Technology
1997-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2023
Wenzhou Medical University
2017-2023
Zhengzhou University
2023
Second Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Abstract Background Bamboo is one of the most important nontimber forestry products worldwide. However, a chromosome-level reference genome lacking, and an evolutionary view alternative splicing (AS) in bamboo remains unclear despite emerging omics data improved technologies. Results Here, we provide de novo assembly moso (Phyllostachys edulis) using additional abundance sequencing Hi-C scaffolding strategy. The significantly scaffold N50 79.90 Mb, approximately 243 times longer than...
Abstract Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, which codon optimization necessary. The existing methods are based on biological indexes. In this paper, we propose a novel method deep learning. First, introduce concept of boxes, via DNA sequences can be recoded into box while ignoring order bases. Then, problem converted to sequence annotation corresponding amino acids with boxes. models Escherichia Coli were trained by...
Increasing the proportion of locally produced plant protein in currently meat-rich diets could substantially reduce greenhouse gas emissions and loss biodiversity1. However, production is hampered by lack a cool-season legume equivalent to soybean agronomic value2. Faba bean (Vicia faba L.) has high yield potential well suited for cultivation temperate regions, but genomic resources are scarce. Here, we report high-quality chromosome-scale assembly genome show that it expanded massive 13 Gb...
In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need develop new antibacterial agents effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine...
Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results phase 2 trial suggested that ziresovir may have efficacy the treatment infants hospitalized RSV infection.
Known as the 'third polar region', Qinghai-Tibet Plateau represents one of harshest highland environments in world and yet a number organisms thrive there. Previous studies birds, animals humans have focused on well-differentiated populations later stages phenotypic divergence. The adaptive processes during initial phase adaptation remain poorly understood. We studied human commensal, Eurasian Tree Sparrow, which has followed agriculture to Plateau. Despite strong differentiation at multiple...
Abstract The number of olfactory receptor genes (ORs), which are responsible for detecting diverse odor molecules varies extensively among mammals as a result frequent gene gains and losses that contribute to specialization. However, how OR expansions/contractions in fish influenced by habitat feeding habit subfamilies important each ecological niche is unknown. Here, we report major expansion freshwater herbivorous fish, Megalobrama amblycephala, using highly contiguous, chromosome-level...
Sweetpotato whitefly, Bemisia tabaci MED/Q and MEAM1/B, are two economically important invasive species that cause considerable damages to agriculture crops through direct feeding indirect vectoring of plant pathogens. Recently, a draft genome B. has been assembled. In this study, we focus on the genomic comparison between with special interest in MED/Q’s signatures may contribute highly nature emerging insect pest. The genomes both share similarity syntenic blocks, but have significant...
Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially rural areas of China where re-emerging is under-reported due lack sustained animal surveillance. By taking advantage detailed genomic and epidemiological data for the outbreak Yunnan Province, China, collected between 1999 2015, we reconstruct demographic dispersal history domestic dog virus (RABV) as well dynamics dog-to-dog dog-to-human transmission....
Abstract The genomic shock of whole-genome duplication (WGD) and hybridization introduces great variation into transcriptomes, for both coding noncoding genes. An altered transcriptome provides a molecular basis improving adaptation during the evolution new species. allotetraploid cotton, together with putative diploid ancestor species compose fine model study rapid gene neofunctionalization over genome shock. Here we report on Drought-Associated Non-coding 1 (DAN1), long intergenic RNA...
Significance Harsh conditions in high elevations present strong stresses for organisms. Previous studies targeting phylogenetically distinct species revealed cases of diversified adaptations, but it remains largely unknown how common ancestry contributes to evolution similar adaptations. Our study based on a complex (snowfinches) living Qinghai–Tibet Plateau shows that ancestral snowfinches had phenotypically evolved larger body size and genetically an accelerated selection genes related...
Water buffalo (Bubalus bubalis), a large-sized member of the Bovidae family, is considered as an important livestock species throughout Southeast Asia. In order to better understand molecular basis improvement and breeding, we sequenced assembled genome (2n=50) river Bubalus bubalis from Bangladesh. Its size 2.77 Gb, with contig N50 25 kb scaffold 6.9 Mbp. Based on genome, annotated 24,613 genes for future functional genomics studies. Phylogenetic tree analysis cattle water lineages showed...
Abstract Chinese mahogany ( Toona sinensis ) is a woody plant that widely cultivated in China and Malaysia. important economically, including as nutritious food source, material for traditional medicine high‐quality hardwood. However, the absence of reference genome has hindered in‐depth molecular evolutionary studies this plant. In study, we report T. assembly, with scaffolds anchored to 28 chromosomes total assembled length 596 Mb (contig N50 = 1.5 scaffold 21.5 Mb). A 34,345 genes were...
This is a report of an anti-GQ1b antibody-negative case Miller-Fisher syndrome, presenting with diplopia and gait disturbance 3 days after catching cold, accompanied by dizziness headache, pain in the eyeballs orbits, superficial sensory loss, ptosis, eye movements fixed middle eyes, limb weakness. Physical examination suggested that patient had muscle strength was reduced, bilateral finger-to-nose heel-knee-shin tests were clumsy dysmetric. Assistant examinations showed albumin-cytologic...
ABSTRACT Faba bean ( Vicia faba L.) is an important pulse crop with a wide range of agroecological adaptations. The development genomic tools and comprehensive catalog extant genetic diversity are crucial for developing improved cultivars. lack cost‐effective genotyping platform limits the characterization large germplasm collections, understanding across populations, implementing breeder's like selection. Genotyping‐by‐sequencing (GBS) offers high‐resolution both model plant species, even...
<title>Abstract</title> Faba bean is a globally adapted legume protein crop with high yield potential. Currently, variation across environments limits more widespread cultivation and the underlying genetics remain unknown. Here, we identify major QTL for faba stability. We genotype ProFaba diversity panel resolution carry out coordinated multi-year/location trials Europe. Based on these data, than one hundred loci associated mean performance stability 14 complex traits, including yield....
Rabies is an important but underestimated threat to public health, with most cases reported in Asia. Since 2000, a new epidemic wave of rabies has emerged Yunnan Province, southwestern China, which borders three countries Southeast We estimated gene-specific evolutionary rates for virus using available data GenBank, then used this information calibrate the timescale (RABV) spread 452 publicly geo-referenced complete nucleoprotein (N) gene sequences, including 52 RABV sequences that were...
Compared to the enormous species diversity of bats, relatively few parvoviruses have been reported. We detected diverse and potentially novel from bats in Hong Kong mainland China. Parvoviruses belonging Amdoparvovirus, Bocaparvovirus Dependoparvovirus were alimentary, liver spleen samples 16 different chiropteran five families by PCR. Phylogenetic analysis partial helicase sequences showed that they belonged 25 bocaparvovirus, three dependoparvovirus one amdoparvovirus species. Nearly...
Cisplatin and cetuximab, an anti‑epidermal growth factor receptor (EGFR) monoclonal humanized antibody, have been used for treatment of laryngeal squamous cell carcinoma (LSCC). It has demonstrated that cisplatin inhibition EGFR signaling may induce endoplasmic reticulum (ER) stress‑associated apoptosis. However, ER protein thioredoxin domain‑containing 5 (TXNDC5) reportedly protects cells from The present study investigated the interaction between cisplatin, cetuximab TXNDC5 on apoptosis in...
Abstract This study explored Cisplatin resistance effect of microRNA‐21 (miR‐21) antisense oligonucleotide (AS‐ODN) in human melanoma A375 cell. AS‐ODN was transfected cells and Cisplatin‐resistant cell line A375/CDDP, divided into the AS‐ODN, nonsense (NS‐ODN) normal groups. Cell ultrastructure changes were observed through transmission electron microscope. MiR‐21 could be tested growth different time periods by trypan blue exclusion. mRNA expression change detected quantitative...
The freshwater leech Whitmania pigra (W. pigra) Whitman (Annelida phylum) is a model organism for neurodevelopmental studies. However, molecular biology research on its embryonic development still scarce. Here, we described series of developmental stages the W. embryos and defined five broad embryogenesis: cleavage stages, blastocyst stage, gastrula organogenesis refinement, juvenile. We obtained total 239.64 Gb transcriptome data eight representative phases (from stage to maturity), which...