A5023415296- Research in Cotton Cultivation
- Plant and Fungal Interactions Research
- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Plant Molecular Biology Research
- Rice Cultivation and Yield Improvement
- Plant Reproductive Biology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Wheat and Barley Genetics and Pathology
- GABA and Rice Research
- Systemic Sclerosis and Related Diseases
- Chromosomal and Genetic Variations
- Protein Tyrosine Phosphatases
- Inflammatory Myopathies and Dermatomyositis
- Plant Stress Responses and Tolerance
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Spondyloarthritis Studies and Treatments
- Salivary Gland Disorders and Functions
- Vitamin D Research Studies
- Plant responses to water stress
- Gout, Hyperuricemia, Uric Acid
- Asthma and respiratory diseases
- Sleep and related disorders
Nanjing Agricultural University
2020-2025
Zhejiang University
2020
Polyploidy is a prominent feature for genome evolution in many animals and all flowering plants. Plant polyploids often show enhanced fitness diverse extreme environments, but the molecular basis this remains elusive. Soil salinity presents challenges plants including agricultural crops. Here we report that salt tolerance tetraploid rice through lower sodium uptake correlates with epigenetic regulation of jasmonic acid (JA)-related genes. induces DNA hypomethylation potentiates genomic loci...
Abstract Hundreds of plant species have been domesticated to feed human civilization, while some crops undergone de-domestication into agricultural weeds, threatening global food security. To understand the genetic and epigenetic basis crop domestication de-domestication, we generated DNA methylomes from 95 accessions wild rice (Oryza rufipogon L.), cultivated sativa L.) weedy (O. f. spontanea). We detected a significant decrease in methylation over course but observed an unexpected increase...
The dissection of a gene regulatory network (GRN) that complements the genome-wide association study (GWAS) locus and crosstalk underlying multiple agronomical traits remains major challenge. In this study, we generate 558 transcriptional profiles lint-bearing ovules at one day post-anthesis from selective core cotton germplasm, which 12,207 expression quantitative trait loci (eQTLs) are identified. Sixty-six known phenotypic GWAS colocalized with 1,090 eQTLs, forming 38 functional GRNs...
Abstract The genomic shock of whole-genome duplication (WGD) and hybridization introduces great variation into transcriptomes, for both coding noncoding genes. An altered transcriptome provides a molecular basis improving adaptation during the evolution new species. allotetraploid cotton, together with putative diploid ancestor species compose fine model study rapid gene neofunctionalization over genome shock. Here we report on Drought-Associated Non-coding 1 (DAN1), long intergenic RNA...
Abstract Cotton fibers, derived from the epidermis of ovule, provide a sustainable natural fiber source for textile industry. Traits related to yield are predominantly determined by molecular regulations in outer integument (OI) region cotton ovule. Here, we identify an R2R3 MYB transcription factor coding gene GhLPF1 within QTL‐LP‐ChrA06 locus lint percentage (LP, seed cotton) through constructing 1‐Day Post Anthesis Ovule Spatial Transcriptome Atlas. is subjected as downstream target...
Observational studies have reported that levels of vitamin D were associated with the incidence chronic obstructive pulmonary disease (COPD), but relationship between them may been confounded in previous studies. In this study, we aimed to determine 25-hydroxyvitamin (25OHD) and risk COPD by two-sample Mendelian randomization (MR) analysis. Summary statistics for 25OHD study obtained from EBI (n = 496,946) consortium Finn 187,754) consortium. MR was adopted explore effect genetically...
Abstract The CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (ESR)–RELATED ( CLE ) gene family encodes a large number of polypeptide signaling molecules involved in the regulation shoot apical meristem division and root vascular bundle development variety plants. genes encode important short peptide hormones; however, functions these polypeptides cotton remain largely unknown. In current work, we studied effects on growth cotton. Based presence conserved motif 13 amino acids, 93 were characterized...
An evolutionary model using diploid and allotetraploid cotton species identified 80 % of non-coding transcripts in as being uniquely activated comparison with its ancestors. The function the lncRNAs remain largely unknown.We employed transcriptome analysis to examine relationship between mRNAs protein coding genes (PCGs) leaf tissue under abiotic stresses. LncRNA expression was preferentially associated that flanking PCGs. Selected highly-expressed lncRNA candidates (n = 111) were subjected...
Abstract Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population. Hypertension is highly prevalent patients polymyositis and dermatomyositis (PM/DM). Owning elevated levels of reactive oxygen species, PM/DM have lower concentrations UA comparison healthy people. We explored a potential association between evaluated whether this independent risk factors, characteristics relevant drugs. A total 472 were assessed. related laboratory data...
Abstract Expression quantitative trait loci (eQTL) provide a powerful means of investigating the biological basis genome-wide association study (GWAS) results and exploring complex traits or phenotypes. In addition to identifying causal gene in cis , eQTL analysis also reveals large number trans-regulated genes located on different chromosomes, which form regulatory network (GRN) that complements GWAS locus. However, dissection GRN crosstalk underlying multiple agronomical traits, along with...
SUMMARY Polyploidy is a prominent driver of plant diversification, accompanied with dramatic chromosomal rearrangement and epigenetic changes that affect gene expression. How chromatin interactions within between subgenomes adapt to ploidy transition remains poorly understood. We generate open interaction maps for natural hexaploid wheat (AABBDD), extracted tetraploid (AABB), diploid progenitor Aegilops tauschii (DD) resynthesized (RHW, AABBDD). Thousands intra‐ interchromosomal loops are de...
Abstract Background The relationship between the lncRNA conservation level and its function is controversial. One of technique barrier to address this question how define conserved non-coding genes across species. Results We developed an evolutionary model using diploid allotetraploid cotton species identify 80% transcripts unique in comparison with ancestors. This led us non-conserved based on their throughout polyploid evolution. LncRNA expression was preferentially associated flanking...