A5100388266- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Cannabis and Cannabinoid Research
- Pulmonary Hypertension Research and Treatments
- Sphingolipid Metabolism and Signaling
- Ion channel regulation and function
- Adenosine and Purinergic Signaling
- Biochemical Analysis and Sensing Techniques
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatitis Pathology and Treatment
- Cellular transport and secretion
- Diabetes and associated disorders
- Cardiac Ischemia and Reperfusion
- Regulation of Appetite and Obesity
- Genetics and Neurodevelopmental Disorders
- Eicosanoids and Hypertension Pharmacology
- Cardiac Fibrosis and Remodeling
- Ion Channels and Receptors
- Forensic Toxicology and Drug Analysis
- Sexual Differentiation and Disorders
Shanxi Medical University
2015-2025
Xi'an Jiaotong University
2019-2025
Ministry of Education of the People's Republic of China
2025
First Hospital of Shanxi Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Hua Medicine (China)
2018-2023
Sweet Potato Research Institute
2023
Weatherford College
2022
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
A common feature among all forms of diabetes mellitus is a functional β-cell mass insufficient to maintain euglycemia; therefore, the promotion growth and survival fundamental goal for prevention treatment. Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on nonerythroid cells. However, influence EPO pancreatic β cells not been evaluated date. In this study, we report recombinant human treatment can protect against development in streptozotocin-induced db/db...
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activator targeting both pancreas liver glucokinase, postprandial in patients with T2D. In this randomized, double-blind, placebo-controlled phase 3 trial, efficacy safety of dorzagliatin as an add-on to metformin were assessed T2D who had inadequate glycemic control using alone. Eligible (n = 767)...
Danshen, the dried root of Salvia miltiorrhiza, is widely used in clinics China for treating various diseases, including cardiovascular diseases. Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative isolated as major active component from was recently reported to be effective attenuating characteristic pulmonary vascular changes associated with chronically hypoxic hypertension (CHPH); however, underlying detailed mechanisms are poorly understood. In this study, we investigated...
BACKGROUND Triple negative breast cancer (TNBC) has a more aggressive recurrence. Previous reports have demonstrated that sphingosine kinase 1 (SphK1) is crucial regulator of progression. However, the correlation SphK1 with clinical prognosis been poorly investigated. Thus, we aimed to elaborate role in TNBC metastasis. MATERIAL AND METHODS We first determined level tissue samples and cells. Furthermore, expression HER2 phosphor-SphK1 (pSphK1) human was by immunohistochemical analysis....
To investigate the pharmacokinetics and pharmacodynamics of a dual-acting glucokinase activator, dorzagliatin, its safety, tolerability effect on pancreatic β-cell function in Chinese patients with type 2 diabetes (T2D).A total 24 T2D were selected, utilizing set predefined clinical biomarkers, randomized to receive dorzagliatin 75 mg twice or once daily (BID, QD respectively) for 28 days. Changes HbA1c glycaemic parameters from baseline Day assessed. In addition, changes 32...
Abstract: Uric acid (UA) is the end product of purine metabolism in human, and imbalance between production excretion results disturbance serum uric (SUA). There evidence suggesting that pituitary-target gland hormones can affect UA through regulating activity xanthine oxidase transporters. Related endocrine diseases including thyroid dysfunction, polycystic ovary syndrome, acromegaly Cushing’s syndrome are often accompanied by elevated levels. In addition to direct influence abnormal...
Abnormal vascular smooth muscle cell (VSMC) proliferation is involved in the development of diseases. However, mechanisms by which insulin exerts this effect are not completely known. We hypothesize that microRNAs might be insulin-induced VSMC proliferation.VSMC was determined [H]-thymidine incorporation; were microRNA chips and real-time PCR; p21expression immunoblotting.In study, we found increased miR-208 expression. Overexpression basal insulin-mediated proliferation. Although a...
Visinin-like protein-1 (VILIP-1) is a member of the neuronal Ca2+ sensor protein family that modulates Ca2+-dependent cell signaling events. VILIP-1, which expressed primarily in brain, increases cAMP formation neural cells by modulating adenylyl cyclase, but its functional role other tissues remains largely unknown. In this study, we demonstrate VILIP-1 murine pancreatic islets and β-cells. To gain insight into functions β-cells, used both overexpression small interfering RNA knockdown...
Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process pulmonary arterial hypertension (PAH). BMP4 plays an important role during remodeling and mutant principle receptor, BMP receptors II (BMPRII), is found to associate with development PAH. However, likely mechanism defining contribution BMPRII mediated smooth muscle cells (PASMCs) remains comprehensively unclear. We previously that enhanced store operated calcium entry (SOCE) basal...
Monkeys with insulin-dependent diabetes are important experimental models for islet xenotransplantation. However, regard to induction, total pancreatectomy is a difficult operation high complication rate, while streptozotocin (STZ) administration may cause serious toxic effects and individual difference in metabolism. We compared two strategies involving STZ successfully safely induce rhesus monkeys. Thirteen monkeys were divided into groups: single high-dose (80, 100 120 mg/kg, n = 3 each...
Recent studies indicate that multiple bone morphogenetic protein (BMP) family ligands and receptors are involved in the development of pulmonary arterial hypertension, yet underlying mechanisms incompletely understood. Although BMP2 BMP4 share high homology amino acid sequence, they appear to exert divergent effects on chronic hypoxic hypertension (CHPH). While promotes vascular remodeling, prevents CHPH. We previously demonstrated upregulates expression canonical transient receptor...
Background The 2021 Global Burden of Disease (GBD) study shows a continuous increase in the burden chronic kidney disease due to diabetes mellitus type 2 (CKD-T2DM) from 1990 2021. This examines influence dietary risk factors across various populations and socioeconomic groups. Methods Utilizing GBD data, we analyzed age-standardized CKD-T2DM metrics—including mortality, disability-adjusted life years (DALY), rates (ASR)—stratified by age, gender, region. employs estimated annual percentage...
The features of community-acquired pneumonia (CAP) patients with type 2 diabetes mellitus (T2DM) differ from those without. This study aims to spot a routinely tested parameter discriminative, predictive and prognostic value enhance CURB-65's accuracy in CAP T2DM. We retrospectively studied consecutive 2020 2021, comparing laboratory parameters between without Receiver operating characteristic (ROC) curve analysis, univariate multivariate logistic regression were used identify key...
Airway smooth muscle (ASM) contraction is an important component of the pathophysiology asthma. Taurine, agonist glycine receptor chloride (GlyR Cl(-)) channels, was found to relax contracted ASM, which led us question whether functional GlyR Cl(-) channels are expressed in ASM. Messenger RNA for β (GLRB), α1 (GLRA1), α2 (GLRA2), and α4 (GLRA4) subunits were human (Homo sapiens) guinea pig (Cavia porcellus) tracheal muscle. Immunoblotting confirmed protein expression GLRA1 GLRB Electrical...
// Shifei Li 1 , Yan Zhou Xiaodong Zheng Xiujuan Wu Yueyang Liang Shushu Wang Yi Zhang Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China Correspondence to: Zhang, email: zhangyi1489@sina.com Keywords: Sphk1, NF-κBp65, CyclinD1, cell proliferation Received: August 08, 2016 Accepted: October 22, Published: November 02, 2016 ABSTRACT Lipid metabolism is crucially involved with the promotion of malignant...