A5012421463- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Ultrasound and Hyperthermia Applications
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Nanocluster Synthesis and Applications
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Molecular Junctions and Nanostructures
- Quantum Dots Synthesis And Properties
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
- Electrochemical sensors and biosensors
- Microfluidic and Bio-sensing Technologies
- Iron oxide chemistry and applications
- Extracellular vesicles in disease
- Conducting polymers and applications
- Tissue Engineering and Regenerative Medicine
Nanjing Drum Tower Hospital
2021-2025
North University of China
2008-2025
Southeast University
2016-2025
Nanjing University
2009-2025
Changzhou University
2016-2025
Catalytic Materials (United States)
2017-2025
Liaoning University
2023-2025
University of Michigan
2025
Zunyi Medical University
2022-2025
Dalian Medical University
2025
Iron oxide nanoparticles (IONPs) are frequently used in biomedical applications, yet their toxic potential is still a major concern. While most studies of biosafety focus on cellular responses after exposure to nanomaterials, little reported analyze reactions the surface as source cytotoxicity. Here we report that different intracellular microenvironment which IONPs located leads contradictive outcomes abilities produce free radicals. We first verified pH-dependent peroxidase-like and...
The generation of reactive oxygen species (ROS) is an important mechanism nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics inhibit •OH generation. theorized for first time activities likely caused by abundant redox...
Co3O4 nanoparticles (Co3O4 NPs), synthesized by the coprecipitation method, showed intrinsic catalase-like, peroxidase-like, and SOD-like activity. The catalytic activity of NPs was much higher than analogous Fe3O4 NPs. Co3O4's mechanisms were analyzed in detail using electron spin resonance (ESR) which confirmed that don't follow classical Fenton reactions with hydrogen peroxide way do. high redox potential Co3+/Co2+ supposed to be leading cause differences both mechanism Fe3O4. Based on...
In hippocampal pyramidal cells, a single action potential (AP) or burst of APs is followed by medium afterhyperpolarization (mAHP, lasting approximately 0.1 s). The currents underlying the mAHP are considered to regulate excitability and cause early spike frequency adaptation, thus dampening response sustained excitatory input relative responses abrupt excitation. was originally suggested be primarily caused M-channels (at depolarized potentials) h-channels more negative potentials), but not...
Prussian blue (PB) modified γ-Fe2O3 magnetic nanoparticles (MNPs) featuring varying PB proportions were synthesized and characterized by TEM, FTIR, UV-vis, EDS, XRD XPS. The properties peroxidase-like catalytic activity of the investigated. With increasing content, magnetism could still maintain a high level. Peroxidase-like was enhanced as proportion increased. Catalysis found to follow Michaelis–Menten kinetics. calculated kinetic parameters exhibited strong affinity with substrates...
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Silver nanoparticles (Ag NPs) are cytotoxic to cancer cells and possess excellent potential as an antitumor agent. A variety of have been shown induce autophagy, a critical cellular degradation process, the elevated autophagy in most these situations promotes cell death. Whether Ag NPs can how it might affect anticancer activity has not reported. Here we show that induced by activating PtdIns3K signaling pathway. The was characterized enhanced autophagosome formation, normal cargo...
Abstract Alzheimer's disease ( AD ) is an age‐related neurodegenerative disorder characterized by memory impairments. Brain oscillatory activity critical for cognitive function and altered in patients. Recent evidence suggests that accumulation of soluble amyloid‐beta A β) induces reorganization hippocampal networks. However, whether fine changes network might be present at very early stages, before β overproduction, remains to determined. We therefore assessed theta gamma oscillations their...
A novel nanofibrous composite scaffold composed of super-paramagnetic γ-Fe2O3 nanoparticles (MNP), hydroxyapatite (nHA) and poly lactide acid (PLA) was prepared using electrospinning technique. The well responds extern static magnetic field with typical saturation magnetization value 0.049 emu/g as possesses architecture. scaffolds were implanted in white rabbit model lumbar transverse defects. Permanent magnets are fixed the cages to provide for rabbits post surgery. Results show that MNP...
Glutathione (GSH) can significantly and selectively enhance the fluorescence intensity of Au nanoclusters (NCs) prepared by blending HAuCl 4 histidine in solution. The quantum yield NCs after adding GSH reach above 10%. Besides, capping shifts excitation peak from ultraviolet (386 nm) to visible light (414 improves stability NCs. cytotoxicities with without for normal lung cells (ATII) cancerous (A549) are evaluated. GSH‐capped have much less cytotoxicity both cancer cells, as compared those...
A novel magnetic hydrogel is formed via the field-directed assembly of nanomaterials during gelation process. The exhibits direction-dependent thermogenesis in an alternating field. specific absorption rate value direction along assemblies can be 2.1-fold as much that normal to while heating 6-8-fold. Due anisotropic thermogenesis, also shows a release drugs has 3.4-fold difference between two directions.