A5101594182- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Alzheimer's disease research and treatments
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Chemical Synthesis and Analysis
- Molecular spectroscopy and chirality
- Gut microbiota and health
- Analytical Chemistry and Chromatography
- Molecular Sensors and Ion Detection
- Mesenchymal stem cell research
- Gold and Silver Nanoparticles Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Protein Interaction Studies and Fluorescence Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Sulfur-Based Synthesis Techniques
- Probiotics and Fermented Foods
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Synthesis of Indole Derivatives
Jiangsu Normal University
2013-2025
Shaanxi Normal University
2025
Affiliated Hospital of Southwest Medical University
2018-2025
ShanghaiTech University
2025
Zunyi Medical University
2025
Zhejiang University of Technology
2024
Panyu District Central Hospital
2012-2024
Southern Medical University
2017-2023
Changzhou No.2 People's Hospital
2018-2023
Nanjing Medical University
2014-2023
It has long been known that probiotics can be used to maintain intestinal homeostasis and treat a number of gastrointestinal disorders, but the underlying mechanism remained obscure. Recently, increasing evidence supports notion certain probiotic-derived components, such as bacteriocins, lipoteichoic acids, surface layer protein secreted protein, have similar protective role on barrier function live probiotics. These bioactive components named 'postbiotics' in most recent publications. We...
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal inflammatory with no effective treatment. It known that postbiotics have gained widely attention because of their outstanding advantages in health issues. In previous studies, we characterized novel Lactobacillus rhamnosus GG (LGG)-derived postbiotic, HM0539, significant protective effects against the murine colitis, but precise mechanism unclear yet. this study, hypothesized function HM0539 might be derived by modulation...
Background & AimsPrevious studies confirm vonoprazan-amoxicillin effectiveness for Helicobacter pylori. This study aims to investigate vonoprazan with varying amoxicillin dose and duration.MethodsThis multicenter, prospective, randomized controlled, noninferiority trial enrolled patients treatment naive H pylori infection from 5 clinical centers. Eligible participants were randomly assigned H-VA-10 (vonoprazan 20 mg twice a day (b.i.d.) + 750 4 times day, 10 days), L-VA-10 b.i.d. 1000 b.i.d,...
Despite a well-established and growing body of work on nickel(0) precatalysts, the potential complexes as bifunctional precatalysts remains underexplored. In this study, we synthesized, characterized, evaluated catalytic activity (Ni(0)(DQ)dtbbpy), bifunctional, red-light-sensitive, air-stable complex. Owing to its unique photophysical properties, it effectively catalyzed etherification amination aryl bromides under 620–630 nm light irradiation, functioning both photocatalyst an active metal...
Amyloid-beta protein (Aβ) deposition is a pathological hallmark of Alzheimer's disease (AD). Aβ triggers both pro-neuroinflammatory microglial activation and neurofibrillary tangle formation. Cromolyn sodium an asthma therapeutic agent previously shown to reduce levels in transgenic AD mouse brains after one-week treatment. Here, we further explored these effects as well the mechanism action cromolyn, alone, combination with ibuprofen APPSwedish-expressing Tg2576 mice. Mice were treated for...
Proteus mirabilis is commonly considered to be an opportunistic pathogen causing urinary tract infections (UTIs) in humans. However, some strains of P. were found associated with food poisoning outbreaks, the pathogenic mechanism still unclear. In our study, we described a novel strain C02011 isolated from patients' specimens China. order determine its gastrointestinal pathogenicity, experiments performed compare B02005 (isolated healthy people) and American Type Culture Collection (ATCC)...
Alzheimer's disease (AD) is one of the top public health crises in 21st century, especially an aging society. Early diagnosis, prevention, and intervention can significantly reduce risk AD. Detection multiple AD biomarkers blood effective strategy has drawn more attention recent years. However, concentration very low, therefore, point-of-care testing (POCT) techniques are needed for sensitive detection. Herein, a lateral flow assay, based on Surface-enhanced Raman scattering nanotags...
The silica gel-catalyzed synthesis of 5-amino-2-aryl-3H-chromeno[4,3,2-de][1,6]naphthyridine-4-carbonitriles and 5-amino-2-aryl-3H-quinolino[4,3,2-de][1,6]naphthyridine-4-carbonitriles were simply achieved upon the one-pot cascade reaction malononitrile with substituted 2-hydroxyacetophenone (or 2-aminoacetophenone) aromatic aldehyde in aqueous media. mechanistic investigation results based on electrospray ionization mass spectrometry (ESI-MS) indicated that displayed a dual role during this...
To explore the mechanisms underlying spontaneous transformation of mesenchymal stem cells (MSCs), changes in senescence-associated molecules, particularly epigenetic modification p16(INK4a) gene, including histone H3 lysine 27/9 methylation (H3K27/9me) and DNA methylation, were investigated cultured adult rat bone marrow MSCs at different stages during process. It was shown that underwent replicative senescence after 24 to 25 population doublings, characterized by positive staining for...
Background and Purpose: Intracerebral hemorrhage (ICH) is a severe disease without effective therapeutic means. Adiponectin (APN) strongly expressed in human brain tissue cerebrospinal fluid may play an anti-inflammatory role following ICH. NLR family pyrin domain-containing protein 3 (NLRP3) member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family. Following ICH, activation NLRP3 inflammasome promotes neuroinflammation edema. Here, we examined effect APN on...
Objective O-linked N-acetylglucosaminylation (O-GlcNAcylation), controlled by O-GlcNAcase (OGA) and O-GlcNAc transferase (OGT), is an important post-translational modification of eukaryotic proteins plays essential role in regulating gut inflammation. Gut microbiota encode various enzymes involved O-GlcNAcylation. However, the characteristics, abundance function these are unknown. Design We first investigated structure taxonomic distribution bacterial OGAs OGTs. Then, we performed...
In contrast to Type-II photodynamic therapy (PDT), Type-I PDT with less oxygen consumption has shown great potential against tumor hypoxia. However, there are limited strategies available for designing photosensitizers (PSs). Herein, we present a promising strategy synthesizing PSs (TBC-1–TBC-4) using Tröger's base (TB) framework. The TB framework can promote intersystem crossing efficiency and create an electron-rich environment, making it the most likely site electron transfer O2 generate...