A5101786148- Gout, Hyperuricemia, Uric Acid
- Vibrio bacteria research studies
- Nitric Oxide and Endothelin Effects
- Molecular Sensors and Ion Detection
- Adenosine and Purinergic Signaling
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Metal-Organic Frameworks: Synthesis and Applications
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Salmonella and Campylobacter epidemiology
- Covalent Organic Framework Applications
- Diet, Metabolism, and Disease
- Cardiac Ischemia and Reperfusion
- COVID-19 Clinical Research Studies
- Mesenchymal stem cell research
- Pharmacological Effects of Natural Compounds
- Luminescence and Fluorescent Materials
- Identification and Quantification in Food
- Synthesis and biological activity
- Pulmonary Hypertension Research and Treatments
- Genomics and Phylogenetic Studies
- Urticaria and Related Conditions
China Pharmaceutical University
2016-2025
Shenzhen Center for Disease Control and Prevention
2015-2025
Xiangya Hospital Central South University
2006-2025
University of South China
2017-2025
Central South University
2006-2025
Jiangxi Provincial Children's Hospital
2018-2025
State Key Laboratory of Natural Medicine
2016-2024
Shenzhen Nanshan Center for Chronic Disease Control
2024
Nanjing Forestry University
2023-2024
East China University of Technology
2023-2024
Rationale: The regenerative potential of the heart is insufficient to fully restore functioning myocardium after injury, motivating quest for a cell-based replacement strategy. Bone marrow–derived mesenchymal stem cells (MSCs) have capacity cardiac repair that appears exceed their differentiation into myocytes. Objective: Here, we test hypothesis bone marrow derived MSCs stimulate proliferation and endogenous (CSCs) as part repertoire. Methods And Results: Female Yorkshire pigs (n=31)...
The mechanism(s) underlying cardiac reparative effects of bone marrow-derived mesenchymal stem cells (MSC) remain highly controversial. Here we tested the hypothesis that MSCs regenerate chronically infarcted myocardium through mechanisms comprising long-term engraftment and trilineage differentiation. Twelve weeks after myocardial infarction, female swine received catheter-based transendocardial injections either placebo (n = 4) or male allogeneic (200 million; n 6). Animals underwent...
Increased fructose consumption predisposes the liver to nonalcoholic fatty disease (NAFLD), but mechanisms are elusive. Thioredoxin-interacting protein (TXNIP) links oxidative stress NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation and this signaling axis may be involved in fructose-induced NAFLD. Here, we explore role of reactive oxygen species (ROS)-induced TXNIP overexpression fructose-mediated hepatic NLRP3 activation, inflammation, lipid...
The power electronics tend to become miniaturized and multifunctionalized, such as thermal rotators, circuit breakers, microchips, which have necessitated creating instruments for investigating mechanisms enhancing conductivity. In this paper, we construct the heat flow network of spherical boron nitride (BN) used multiscale BN improve conductivity composite synergistically. filler ratio optimization model based on Dinger–Funk particle stacking theory is established, obtained optimal volume...
Carbonization of epoxy resin under high voltage discharge or exposure to temperatures results in insulation failure. Herein, multiscale spherical boron nitride (SBN) is developed with improved anticarbonization properties. The thermal conductivity, thermostability, dielectric performances, volume resistivity, breakdown strength, and flame retardancy the epoxy-SBN composites were studied. strength are higher than that pure resin, a ratio conductivity 24 resistivity ∼10. AC epoxy-30SBN was as...
Abstract Extracting rare earth elements (REEs) from wastewater is essential for the growth and an eco-friendly sustainable economy. However, it a daunting challenge to separate individual by their subtle differences. To overcome this difficulty, we report unique REE nanotrap that features dense uncoordinated carboxyl groups triazole N atoms in two-fold interpenetrated metal-organic framework (named NCU-1). Notably, synergistic effect of suitable pore sizes nanotraps NCU-1 highly responsive...
Hyperuricemia and gout appear to be rapidly increasing worldwide frequently cause symptoms of metabolic syndrome. Dietary flavonoids have their potential beneficial effects on human health. In the present study, 15 (quercetin, morin, myricetin, kaempferol, icariin, apigenin, luteolin, baicalin, silibinin, naringenin, formonoetin, genistein, puerarin, daidzin naringin dihydrochalcone) were selected investigate for hypouricemic action in mice. Oral administration quercetin, apigenin puerarin...
Dominant mutations in glycyl-tRNA synthetase (GlyRS) cause a subtype of Charcot-Marie-Tooth neuropathy (CMT2D). Although previous studies have shown that GlyRS mutants aberrantly interact with Nrp1, giving insight into the disease's specific effects on motor neurons, these cannot explain length-dependent axonal degeneration. Here, we report HDAC6 and stimulate its deacetylase activity α-tubulin. A decrease α-tubulin acetylation deficits transport are observed mice peripheral nerves prior to...
Abstract Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease. Among purinoceptors, only P2Y 14 R is positively correlated with score mucosal biopsies ulcerative colitis patients, nevertheless, remains unclear. Here, based on over-expressions intestinal epithelium mice experimental colitis, we find that male lacking epithelial cells exhibit less injury induced by dextran sulfate sodium. Mechanistically, deletion limits transcriptional activity...
Acute liver failure (ALF) is lack of broadly approved therapeutic strategy except transplantation. As a glycogen metabolic intermediate, UDP-glucose (UDP-G) has been considered to accelerate repairment. Nevertheless, the role UDP-G and its receptor P2Y purinoceptor 14 (P2Y14R) in ALF remains unknown. The present study aims investigate underlying mechanisms UDP-G/P2Y14R axis ALF. In this study, hepatic P2Y14R significantly increased TAA-induced partial hepatectomy-induced ALF, while knockout...
Fructose consumption has been recently related to an epidemic of metabolic syndrome, and hyperuricemia plays a pathogenic role in fructose-induced syndrome. Fructose-fed rats showed renal dysfunction with reductions the urinary uric acid/creatinine ratio fractional excretion acid (FE ur ), as well other features Lowering serum levels allopurinol, rutin, quercetin increased FE attenuated abnormalities rats, demonstrating that contributed deficiency this model. Furthermore, we found fructose...
High consumption of dietary fructose is an important contributory factor in the development hepatic steatosis insulin or leptin resistance. We investigated effects curcumin on fructose-induced hypertriglyceridemia and liver explored its preventive mechanisms rats. Curcumin reduced serum levels fructose-fed This compound could increase phosphorylation receptor substrate 1 to enhance Akt extracellular signal-regulated kinase1/2 (ERK1/2) activation Moreover, increased janus-activated...
To characterize isolates of Staphylococcus aureus that were associated with staphylococcal food poisoning between 2006 and 2009 in Shenzhen, Southern China, a total 52 from 11 outbreaks analyzed by using multilocus sequence typing (MLST), spa typing, pulsed-field gel electrophoresis (PFGE). PCR analysis was used to analyze the enterotoxin (SE) genes sea sei, antimicrobial susceptibility testing also performed. ST6 most dominant type (ST), constituting 63.5% (34/52) all 7 outbreaks. The next...
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation is attractive drug target for antimicrobial development. Here we report compound ZCL039, a benzoxaborole-based derivative AN2690, as potent anti-pneumococcal agent that inhibits S. LeuRS (SpLeuRS) activity. We show using kinetic, biochemical analyses...
The bromodomain and extra-terminal domain (BET) family of proteins are readers which specifically recognize histone-acetylated lysine residues. Each BET protein contains two highly homologous domains: the first (BD1) second (BD2). Pan-BET inhibition is a potential therapy for various cancers immune-inflammatory diseases, but only few reported inhibitors show selectivity within family. Herein, we identified series benzo[cd]indol-2(1H)-ones pyrrolo[4,3,2-de]quinolin-2(1H)-ones with good BD1....