A5100716500- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Nanoparticle-Based Drug Delivery
- Biopolymer Synthesis and Applications
- Mass Spectrometry Techniques and Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Analytical Chemistry and Chromatography
- Extraction and Separation Processes
- Minerals Flotation and Separation Techniques
- Amino Acid Enzymes and Metabolism
- Cancer, Lipids, and Metabolism
- Sesquiterpenes and Asteraceae Studies
- PI3K/AKT/mTOR signaling in cancer
- Analytical chemistry methods development
- Click Chemistry and Applications
- Advancements in Battery Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- SARS-CoV-2 detection and testing
- Hops Chemistry and Applications
Southeast University
2024-2025
Sichuan Cancer Hospital
2024-2025
University of Electronic Science and Technology of China
2024-2025
State Key Laboratory of Digital Medical Engineering
2024
China Pharmaceutical University
2019-2024
Hainan University
2021
Jiangnan University
2020
Wuxi Institute of Technology
2020
Hunan University of Science and Technology
2020
Zhengzhou University
2019-2020
The site-specific activation of bioorthogonal prodrugs has provided great opportunities for reducing the severe side effects chemotherapy. However, precise control location, sustained drug production at target site, and high reaction efficiency in vivo remain challenges. Here, we propose construction tumor cell membrane reactors to solve above problems. Specifically, tumor-targeted liposomes with efficient fusion capabilities are generated install trigger, amphiphilic tetrazine derivative,...
The bromodomain and extra-terminal domain (BET) family of proteins are readers which specifically recognize histone-acetylated lysine residues. Each BET protein contains two highly homologous domains: the first (BD1) second (BD2). Pan-BET inhibition is a potential therapy for various cancers immune-inflammatory diseases, but only few reported inhibitors show selectivity within family. Herein, we identified series benzo[cd]indol-2(1H)-ones pyrrolo[4,3,2-de]quinolin-2(1H)-ones with good BD1....
Abstract The site‐specific activation of bioorthogonal prodrugs has provided great opportunities for reducing the severe side effects chemotherapy. However, precise control location, sustained drug production at target site, and high reaction efficiency in vivo remain challenges. Here, we propose construction tumor cell membrane reactors to solve above problems. Specifically, tumor‐targeted liposomes with efficient fusion capabilities are generated install trigger, amphiphilic tetrazine...
The incidence of breast cancer is increasing annually, making it a major health threat for women. Chemoprevention using natural, dietary, or synthetic products has emerged as promising approach to address this growing burden. Atractylenolide-III (AT-III), sesquiterpenoid present in various medicinal herbs, demonstrated potential therapeutic effects against several diseases, including tumors, nonalcoholic fatty liver disease, and cerebral ischemic injury. However, its impact on...
Natural antimicrobial agent ε-poly-<sc>l</sc>-lysine could be alternative prepared by ethanol/ammonium sulfate ATPS combined with ultrafiltration from the microbial feedstock.
The EtOH extract of the roots and rhizomes Clematis mandshurica afforded two new lignans clemomanshurinane C (1) D (2), three known compounds (3–5). Their structures were elucidated on basis spectroscopic means hydrolysis products. All displayed moderate inhibitory activity against enzyme lipoxygenase.
This work reports the first example of a colorimetric H<sub>2</sub>S sensor constructed through G-quadruplex-Cu<sup>2+</sup> (G4-Cu<sup>2+</sup>) peroxidase mimetics employing Cu<sup>2+</sup> ions and G-rich DNA with signal amplification.
A novel fluorescent aptasensor based on the G-quadruplex induced quenching of psoralen and competitive interactions between 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT), adenosine triphosphate (ATP) G-rich DNA functionalized split ATP aptamer was proposed. The binding to a significant enhancement in fluorescence emission intensity while undergoing excitation at 340 nm. Under optimal conditions, developed showed high selectivity good accuracy for detecting ATP. practicality proposed has been...