A5101653116- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Sesquiterpenes and Asteraceae Studies
- Plant biochemistry and biosynthesis
- Ginseng Biological Effects and Applications
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Plant Toxicity and Pharmacological Properties
- Advanced biosensing and bioanalysis techniques
- Chemical synthesis and alkaloids
- Insect and Arachnid Ecology and Behavior
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Pituitary Gland Disorders and Treatments
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Natural Compounds in Disease Treatment
- Phytochemical compounds biological activities
- Plant Diversity and Evolution
- Pharmacological Effects of Natural Compounds
- Ziziphus Jujuba Studies and Applications
- Adrenal and Paraganglionic Tumors
- Plant-derived Lignans Synthesis and Bioactivity
Chengdu University
2015-2025
Nanjing Institute of Geology and Paleontology
2022-2025
Chinese Academy of Sciences
2022-2025
University of Chinese Academy of Sciences
2025
Zhejiang University of Technology
2023
Peking Union Medical College Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Chinese Academy of Agricultural Sciences
1997-2022
China National Rice Research Institute
2012-2022
University of Massachusetts Lowell
2021
Nasal drug delivery is a fascinating approach to bypass the blood-brain barrier, which instead directly transports molecules brain from nasal cavity along olfactory and trigeminal nerves. However, feasibility of nose-to-brain transportation intact nanoparticles possible corresponding pathways remain poorly understood. The purpose present study explore intranasal fate curcumin (Cur)-loaded polycaprolactone (PCL NPs) via fluorescent bioimaging strategies. behavior was tracked by...
Seven new triterpene saponins, clematochinenosides A−G (1−7), together with 17 known saponins (8−24), were isolated from the roots and rhizomes of Clematis chinensis. Their structures elucidated on basis spectroscopic evidence hydrolysis products. Compounds 1, 3−7, 20−24 showed inhibitory activities against COX-1 COX-2 enzymes.
l-Methionine is the only sulfur-containing amino acid among essential acids, and it mainly produced by chemical method in industry so far. The fermentation production of l-methionine genetically engineered strains an attractive alternative. Due to complex metabolic mechanism multilevel regulation synthesis pathway organism, was still not satisfied. In this study, biosynthesis regulated based on previous studies. As competitive for cell growth, l-lysine first repaired complementation lysA...
"How old are angiosperms" is a frequently asked but still unanswered question. Although the underlying reason includes lack of consensus on criterion for fossil angiosperms, limited finds, and other factors, final answer to question apparently lies in fossils, not wrangling among different schools. The currently mainstream idea palaeobotany that angiosperms cannot have existed earlier than Early Cretaceous. This 64-year-old stereotype was recently iterated again 2017. However, another...
This study investigated the role of magnoflorine (MAG) on cartilage protection in osteoarthritis. In vitro studies showed that MAG decreased expression inflammatory factors and inhibited extracellular matrix degradation lipopolysaccharide- ATP-stimulated C28/I2 cells. Importantly, reduced levels pyroptosis-related proteins, including NLRP3, ASC, cleaved-caspase 1, GSDMD-N, IL-18, IL-1β. Mechanistically, mtROS production activation NF-κB signaling pathway. vivo demonstrated sodium...
Proteins accumulated in dry, stratified Arabidopsis seeds or young seedlings, totaled 1100 to 1300 depending on the time of sampling, were analyzed by using immobilized pH gradient 2-DE gel electrophoresis. The molecular identities 437 polypeptides, encoded 355 independent genes, determined MALDI-TOF TOF-TOF mass spectrometry. In sum, 293 present at all stages and 95 during radicle protrusion while another 18 appeared later stages. Further analysis showed that 226 identified polypeptides...
A simple but highly specific immunoassay system for goat anti-human IgG has been developed using gold nanoparticles and microfluidic techniques. The assay is based on the deposition of that are coated with protein antigens in presence their corresponding antibodies to channel surface. effects time accumulation, flow velocity, concentration red light absorption percentage (RAP) were investigated an ordinary optical microscope. By controlling reaction a dynamic range 3 orders magnitude...
The midgut is the major organ for food digestion, nutrient absorption and also a barrier foreign substance. 5th-instar larval stage of silkworm very important growth, development, silk production. In present study, we used 2-DE matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) to analyze proteins from larvae as well under starvation condition. A total 96 were identified in this study; among them, 69 observed first time. We found that responded by...