A5032044151- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Chemical Reactions and Isotopes
- Advanced Photocatalysis Techniques
- Advanced Nanomaterials in Catalysis
- Molecular spectroscopy and chirality
- Porphyrin and Phthalocyanine Chemistry
- Synthesis and biological activity
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- Axial and Atropisomeric Chirality Synthesis
- Fungal Plant Pathogen Control
- Catalysis for Biomass Conversion
- Crystallization and Solubility Studies
- Legume Nitrogen Fixing Symbiosis
- Plant Pathogenic Bacteria Studies
Shaanxi Normal University
2023-2025
South China Agricultural University
2024-2025
Nankai University
2017-2023
University of Basel
2022-2023
China Electronics Technology Group Corporation
2022
State Council of the People's Republic of China
2019
Chinese PLA General Hospital
2007
We disclose a method for silver-enabled formal [4π + 2 σ ] cycloaddition reactions between bicyclobutanes and nitrile imines (generated from hydrazonyl chlorides) to furnish diverse array of 2,3-diazo-BCHepes.
Formyl-selective deuteration of aldehydes with D<sub>2</sub>O mediated by the synergistic combination light-driven, polyoxometalate-facilitated HAT and thiol catalysis is reported.
Herein, we report a protocol for direct visible-light-mediated Minisci C–H alkylation of heteroarenes with unactivated alkyl halides using molecular oxygen as an oxidant at room temperature.
A photoredox-mediated direct cross-dehydrogenative coupling reaction to accomplish α-aminoalkylation of N-heteroarenes is reported. This mild has a broad substrate scope, offers the first general method for synthesis aminoalkylated without need prefunctionalization, and scalable gram level. Furthermore, was found be applicable other hydrogen donors besides amines (i.e., ethers, an aldehyde, formamide, p-xylene, alkanes), thus enabling preparation bearing various types substituents.
Herein, we report a mild, operationally simple, multicatalytic method for the synthesis of β,γ-unsaturated ketones via allylic acylation alkenes. Specifically, combines N‑heterocyclic carbene catalysis, hydrogen atom transfer and photoredox catalysis cross-coupling reactions between wide range feedstock carboxylic acids readily available olefins to afford structurally diverse without olefin transposition. The could be used install acyl groups on highly functionalized natural-product-derived...
A mild one-step, light-promoted, three-component radical-coupling reaction of [1.1.1]propellane to afford difunctionalized benzylalcohol-, aldehyde-substituted BCPs in the absence metals, photocatalysts or external oxidants was reported.
Despite a well-established and growing body of work on nickel(0) precatalysts, the potential complexes as bifunctional precatalysts remains underexplored. In this study, we synthesized, characterized, evaluated catalytic activity (Ni(0)(DQ)dtbbpy), bifunctional, red-light-sensitive, air-stable complex. Owing to its unique photophysical properties, it effectively catalyzed etherification amination aryl bromides under 620–630 nm light irradiation, functioning both photocatalyst an active metal...
The polar nature of the C═O bond commonly allows it to undergo direct attack by nucleophiles at electrophilic carbon atom in which ketones and aldehydes act as alkyl carbocation equivalents. In contrast, transformations radical equivalents (generated carbonyl carbon) are unknown. Here, we describe a new catalytic activation mode that combines proton-coupled electron transfer (PCET) with spin-center shift (SCS) enables C─H alkylation heteroarenes using This transformation proceeded via...
Direct visible-light-mediated Minisci C–H alkylation reactions of N-heteroarenes with alkyl boronic acids at room temperature molecular oxygen as an oxidant and acid activation reagent were reported.
In this study, a new C(sp3)–H monofluoroalkenylation reaction involving cooperative visible-light photoredox catalysis and hydrogen-atom-transfer to afford products generated by selective hydrogen abstraction radical–radical cross-coupling was described. This mild, efficient shows high regioselectivity for the α-carbon atoms of amines, ethers, thioethers thus allows preparation monofluoroalkenes bearing various substituents. The applied two bioactive molecules, indicating its utility...
Herein, we report a protocol for direct visible-light-mediated C-I difluoroallylation reactions of α-trifluoromethyl arylalkenes with alkyl iodides at room temperature an α-aminoalkyl radical as mediator. The permits efficient functionalization various cyclic and acyclic primary, secondary, tertiary is scalable to the gram level. This mild uses inexpensive mediator suitable late-stage complex natural products drugs.
Herein, we report a direct, light-mediated defluorosilylation protocol for converting α-trifluoromethyl arylalkenes and alkyl silanes into γ,γ-difluoroallylic compounds via combination of photoredox catalysis hydrogen atom transfer. The clean, convenient can be scaled to the gram level, its mild conditions make it very suitable late-stage functionalization complex natural products drugs.
Despite the ubiquity of alkylboronic acids in organic synthesis, their utility as alkyl radical precursors visible-light-induced photocatalytic reactions is limited by high oxidation potentials. In this study, we demonstrated that an inorganophosphorus compound can modulate potentials so they act precursors. We propose a mechanism based on results fluorescence quenching experiments, electrochemical 11B and 31P NMR spectroscopy, other techniques. addition, describe simple reliable alkylation...
Cheap, stable and easy-to-handle Werner ammine salts have been known for more than a century; but they rarely used in organic synthesis. Herein, we report that the hexammine complex [Ni(NH
Minisci C–H alkylation of N-heteroarenes with 4-alkyl-1,4-dihydropyridines at room temperature molecular oxygen as an oxidant was developed.
A mild general method for difluoromethylthiolation of aldehydes with PhSO2SCF2H and a decatungstate photocatalyst under redox-neutral conditions has been developed. This reaction is highly efficient, scalable, oxidant-free. The broad substrate scope excellent functional group tolerance the make it suitable generating libraries difluoromethyl thioesters. We demonstrated utility sustainability by synthesizing several structurally complex
The widespread presence of secondary amines in agrochemicals, pharmaceuticals, natural products, and small-molecule biological probes has inspired efforts to streamline the synthesis molecules with this functional group.
Herein we report a protocol for the direct visible-light-mediated alkenylation of alkyl boronic acids at room temperature without an external Lewis base as activator, and propose mechanism involving benzenesulfinate activation acids. The permits efficient functionalization broad range cyclic acyclic primary secondary with various alkenyl sulfones. We demonstrated its utility by preparing or functionalizing several pharmaceuticals natural products.
N-Heteroarenes are present in a wide variety of natural products, small-molecule drugs, organic materials, and ligands.Therefore, the methods for selective C-H functionalization N-heteroarenes highly sought-after late-stage modification pharmaceuticals.A useful tool synthesis alkyl-substituted nitrogen-containing aromatic rings is Minisci reaction, which protonated N-heteroarene attacked by an alkyl radical under oxidative acidic conditions.Classic reactions often require use excess oxidant,...
Iron-catalyzed cross-coupling reactions are difficult to achieve because they usually require a highly reactive, low-valent iron catalyst undergo the oxidative addition process. Here, we report method for light-promoted iron-catalyzed C–N coupling between aryl bromides and amines in presence of catalytic amount bipyridine ligand under irradiation at 390–395 nm. This method, which does not external photosensitizers, features broad substrate scope (70 examples) good functional group tolerance,...
In this study, we developed a light-induced difunctionalization of [1.1.1]propellane with heteroaryl sulfones acting as difunctional reagents, allowing the introduction alkyl and units across bicyclo[1.1.1]pentane frameworks. It features broad substrate scope can be used to functionalize structurally complex natural products. Mechanistic investigations indicate Cs