A5028859389- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Viral-associated cancers and disorders
- Tryptophan and brain disorders
- Fermentation and Sensory Analysis
- Plant Pathogens and Fungal Diseases
- Plant Molecular Biology Research
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Plant nutrient uptake and metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Tannin, Tannase and Anticancer Activities
- Prion Diseases and Protein Misfolding
- Monoclonal and Polyclonal Antibodies Research
- Gut microbiota and health
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Biochemical Analysis and Sensing Techniques
- Cancer-related gene regulation
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Plant Stress Responses and Tolerance
Tea Research Institute
2013-2025
Southwest University
2016-2025
Institute of Oceanology
2021-2025
Eye & ENT Hospital of Fudan University
2025
First Affiliated Hospital of Nanchang University
2014-2025
Nanchang University
2014-2025
University of Chinese Academy of Sciences
2009-2025
Hunan Agricultural University
2025
Huazhong University of Science and Technology
2009-2025
Tongji Hospital
2009-2025
Significance The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas (CRISPR-associated) system has been used to generate targeted gene editing in plants. However, it is not known whether CRISPR/Cas-induced modifications plants occur somatic cells only or some all of the can enter germ line become heritable. Through systematic and multigenerational analysis, this study demonstrates that although majority detected first generation CRISPR/Cas transgenic Arabidopsis were...
Although several artificial nanotherapeutics have been approved for practical treatment of metastatic breast cancer, their inefficient therapeutic outcomes, serious adverse effects, and high cost mass production remain crucial challenges. Herein, we developed an alternative strategy to specifically trigger apoptosis tumors inhibit lung metastasis by using natural nanovehicles from tea flowers (TFENs). These had desirable particle sizes (131 nm), exosome-like morphology, negative zeta...
This work investigated the modulatory effects of Pu-erh tea on gut microbiota in ameliorating hyperuricemia induced by circadian rhythm disruption.
Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly PYR/PYL family of receptors, resulting in inhibition type 2C phosphatases (PP2C) activation downstream signaling. It envisioned that intervention signaling by small molecules could help overcome stresses such as drought, cold soil salinity. However, chemical instability rapid catabolism plant enzymes limit practical application itself. Here we report identification a...
DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo plants can be achieved by the RNA-directed (RdDM) pathway, where plant-specific DNA-dependent RNA polymerase IV (Pol IV) transcribes target sequences to initiate 24-nt siRNA production and action. The putative binding protein DTF1/SHH1 of Arabidopsis has been shown associate with Pol required for accumulation transcriptional silencing at several RdDM loci. However, extent mechanism DTF1 function unclear. We...
Although tea polyphenols possess a variety of biological activities, the oxidative stability limits its application in diet as preventive medicine. To enlarge activity polyphenols, we investigated changes with different pH (3, 4, 5, 6, and 7) at temperatures (4, 25, 100°C). Changes transmittance, deterioration, color values, contents catechins were evaluated. The results showed that 3–6 remained stable 4 25°C. With increase temperature, polyphenol solutions became darker less green, but...
The objective of this study was to use next-generation sequencing technologies dissect quantitative trait loci (QTL) for southern root-knot nematode (RKN) resistance into individual genes in soybean. Two hundred forty-six recombinant inbred lines (RIL) derived from a cross between Magellan (susceptible) and PI 438489B (resistant) were evaluated RKN greenhouse sequenced at an average 0.19× depth. A sequence analysis pipeline developed identify validate single-nucleotide polymorphisms (SNPs),...
Polyphenol-enriched herbal extracts have been proved as alternative therapeutic strategies for experimentally induced colitis. The in vivo and vitro anti-inflammatory effects of Camellia sinensis (green, white, yellow, oolong, black, dark tea) Litsea coreana (hawk are comparatively explored.HPLC analysis confirms dissimilarities among phytochemical compositions these teas. tea (TEs) significantly decrease the production pro-inflammatory cytokines (IL-6, IL-12, tumor necrosis factor-α)...
Green and dark tea extract (GTE/DTE) ameliorate chemical-induced colitis in mice; however, the role of gut microbiota anticolitis effects green mice remains unclear. This study aims to explore modulations microbes mediated by fecal transplantation (FMT). Our results indicated that GTE DTE (5 mg/kg bodyweight/day for 4 weeks) exhibited prebiotic on donor mice. Moreover, FMT treatments (transferring daily from 1 g/kg bodyweight sample each recipient) that, compared with normal diet-treated...
Ripened pu-erh tea has the biological activity of antioxidation and anti-inflammation, which inhibits related parameters colitis. However, role storage-induced changes in bioactive ingredients ripened colitis remains unclear. In this study, 3.5% dextran sulfate sodium-induced mice were treated with 10 mg/kg bw/day extracts, aged 14 years (P2006) unaged (P2020) tea, respectively, for 1 week. We found that especially P2006, inhibited intestinal oxidative stress-mediated inflammation pathway...
This study investigated the protective effects of pu-erh tea extract (PTE) on alcohol-induced microbiomic and metabolomic disorders. In chronic alcohol-exposed mice, PTE ameliorated alcoholic consumption-induced oxidative stress, inflammation, lipid accumulation, liver colon damage through modulating responses. restored fecal microbiota dysbiosis by elevating relative abundance potentially beneficial bacteria, for example, Bifidobacterium Allobaculum, decreasing harmful Helicobacter...
The objective of this study was to investigate the diagnosis and management skull base osteoradionecrosis (ORN) after radiotherapy for nasopharyngeal carcinoma (NPC).The general information, clinical manifestations, treatment outcomes were retrospectively evaluated in 15 patients with ORN NPC.The common symptoms included foul odor, headache, epistaxis. Endoscopic examination showed exposed bone or sequestration nasopharynx. characteristic findings according computed tomography following:...
Significance The histone 3 lysine 9 demethylase Increase in BONSAI Methylation 1 (IBM1) is critical for preventing CHG (H=A, T, or C) methylation plant genes. We found that the putative chromatin regulator Enhanced Downy Mildew 2 (EDM2) controls genome and transgene silencing by regulating alternative polyadenylation of IBM1 . EDM2 contains a composite homeo domain simultaneously recognizes both repressive active marks, allowing it to associate specifically with intronic heterochromatin...
Significance The epigenome influences gene regulation and genome evolution. DNA methylomes of Arabidopisis hybrids are distinct from both parents; however, how the parental interact in is poorly understood. We discovered pervasive, nonadditive methylation changes (“methylation interactions”) throughout Col C24 Arabidopsis accessions. Methylation interactions correlated with high levels small interfering RNAs, known components RNA-directed (RdDM) pathway. Indeed, abrogation RdDM activity...
We were employing nanotechnology to improve the targeting ability of (-)-Epigallocatechin-3-gallate (EGCG) towards MCF-7 cells, and two kinds EGCG nanoparticles (FA-NPS-PEG FA-PEG-NPS) obtained, besides, their characteristics effects on cells studied. The results indicated that (i) both FA-NPS-PEG FA-PEG-NPS have high stabilities; (ii) particles sizes 185.0 ± 13.5 nm 142.7 7.2 nm, respectively; (iii) encapsulation efficiencies 90.36 2.20% 39.79 7.54%, respectively. (iv) there was no...
Gray blight of tea, caused by several Pestalotiopsis-like species, is one the most destructive foliar diseases in tea cultivation yet characteristics these pathogens have not been confirmed until now. With morphological and multigene phylogenetic analyses, we identified gray fungi as Pseudopestalotiopsis camelliae-sinensis, Neopestalotiopsis clavispora, Pestalotiopsis camelliae. Phylogenetic analyses derived from combined internal transcribed spacer, β-tubulin, translation elongation factor...
Nanoparticles (NPs) have the capacity to improve bioactivity and bioavailability of anti-inflammatory drugs. Here, a green drug nanocarrier based on ovalbumin (OVA) was facilely produced via self-assembling process by adding epigallo-catechin 3-gallate (EGCG) aqueous solution OVA at 80 °C. The obtained EGCG-NPs had an average hydrodynamic diameter (around 202.9 nm), negative surface charge (approximately −13.2 mV), high EGCG encapsulation efficiency (98.1%), reduction-responsive release...