A5074905580- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Microbial Natural Products and Biosynthesis
- Food Quality and Safety Studies
- Natural product bioactivities and synthesis
- Fermentation and Sensory Analysis
- Plant Molecular Biology Research
- Plant Pathogens and Fungal Diseases
- Alzheimer's disease research and treatments
- Fungal Biology and Applications
- Cancer-related Molecular Pathways
- Microbial Metabolism and Applications
- Plant Gene Expression Analysis
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Dementia and Cognitive Impairment Research
- Plant tissue culture and regeneration
- Cellular transport and secretion
- RNA modifications and cancer
- Plant Reproductive Biology
- HIV Research and Treatment
- Heavy Metals in Plants
- Bioactive Compounds and Antitumor Agents
Chinese Academy of Agricultural Sciences
2016-2025
Tea Research Institute
2016-2025
Hangzhou DAC Biotech (China)
2025
Capital Medical University
2025
Chongqing University
2024-2025
Ministry of Agriculture and Rural Affairs
2020-2024
Xinjiang Academy of Agricultural Sciences
2024
Institute of Plant Protection
2024
Tianjin University of Science and Technology
2024
Heinrich Heine University Düsseldorf
2020-2024
Dissecting SNARE Zippering The complex is critical for vesicle fusion, notably during release of neurotransmitters at synapses. Understanding the biophysics assembly has been object several structural studies, and yet much remains to be understood about mechanisms. Now, Gao et al. (p. 1340 , published online 16 August; see Perspective by Rizo ) describe results cell-free experiments using optical tweezers elucidate disassembly complex. Direct observations intermediates revealed multiple...
Summary Flavor‐associated volatile chemicals make major contributions to consumers’ perception of fruits. Although great progress has been made in establishing the metabolic pathways associated with synthesis, much less is known about regulation those pathways. Knowledge how are regulated would greatly facilitate efforts improve flavor. Volatile esters contributors fruity flavor notes many species, providing a good model investigate synthesis Here we initiated study peach ( Prunus persica L....
Background: Insulin resistance (IR) affects the development of type 2 diabetes mellitus (T2DM), which is also influenced by accumulated fine particle air pollution [particulate matter (PM) with aerodynamic diameter <2.5μm (PM2.5)] exposure. Previous experimental and epidemiological studies have proposed several potential mechanisms PM2.5 contributes to IR/T2DM, including inflammation imbalance, oxidative stress, endothelial dysfunction. Recent evidence suggests that imbalance gut microbiota...
N 6 -methyladenosine (m A) is a fundamentally important RNA modification for gene regulation, whose function achieved through m A readers. However, whether and how readers play regulatory roles during fruit ripening quality formation remains unclear. Here, we characterized SlYTH2 as tomato reader protein profiled the binding sites of at transcriptome-wide level. undergoes liquid–liquid phase separation promotes RNA–protein condensate formation. The target mRNAs SlYTH2, namely A-modified...
Abstract Here, we report our effort in generating an ORFeome collection for the Arabidopsis transcription factor (TF) genes. In total, clones representing 1,282 TF genes have been obtained Gateway high throughput cloning pENTR vector, including 411 whose annotation lack cDNA support. All inserts also mobilized into a yeast expression destination with estimated 85% rate of expressing respective proteins. Sequence analysis these revealed that 34 them did not match either reported cDNAs or...
Summary Chloroplast development and chlorophyll(Chl)metabolism in unripe tomato contribute to the growth quality of fruit, however these mechanisms are poorly understood. In this study, we initially investigated seven homeobox‐containing transcription factors ( TF s) with specific ripening‐associated expression patterns using virus‐induced gene silencing VIGS ) technology found that inhibiting one s, BEL 1‐ LIKE HOMEODOMAIN 11 (Sl 11), significantly increased Chl levels fruit. This enhanced...
Synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins couple their stage-wise folding/assembly to rapid exocytosis of neurotransmitters in a Munc18-1-dependent manner. The functions the different assembly stages and role Munc18-1 SNARE are not well understood. Using optical tweezers, we observed four distinct N-terminal, middle, C-terminal, linker domains (or NTD, MD, CTD, LD, respectively). We found that layer mutations differentially affect assembly....
Background: Cuproptosis is a new type of cell death that induces protein toxic stress and eventually leads to death. Hence, regulating cuproptosis in tumor cells therapeutic approach. However, studies on cuproptosis-related long noncoding RNA (lncRNA) head neck squamous carcinoma (HNSC) have not been found. This study aimed explore the lncRNAs prognostic marker their relationship immune microenvironment HNSC by using bioinformatics methods. Methods: sequencing, genomic mutations, clinical...
Kojic acid, β-arbutin, α-arbutin, and deoxyarbutin have been reported as tyrosinase inhibitors in many articles, but some contradictions exist their differing results. In order to provide explanations for these find the most suitable compound a positive control screening potential inhibitors, activity inhibition type of aforementioned compounds on monophenolase diphenolase mushroom (MTYR) were studied. Their effects B16F10 cells melanin content, (BTYR) activity, cell viability also exposed....
Flavor-imparting volatile chemicals accumulate as fruits ripen, making major contributions to taste. The NAC transcription factor nonripening (NAC-NOR) and DNA demethylase 2 (SlDML2) are essential for tomato fruit ripening, but details of the potential roles relationship between these two regulators in synthesis volatiles lacking. Here, we show substantial reductions fatty acid carotenoid-derived slnor sldml2 mutants. An unexpected finding is redundancy divergence profiles, biosynthetic gene...
Chronic neuroinflammation with sustained microglial activation occurs in Parkinson's disease (PD), yet the mechanisms and exact contribution of these cells to neurodegeneration remains poorly understood. In this study, we induced progressive dopaminergic neuron loss mice via rAAV-hSYN injection cause neuronal expression α-synuclein, which produced behavioral alterations. We administered PLX5622, a colony-stimulating factor 1 receptor inhibitor, for 3 weeks prior injection, maintaining it 8...
Theaflavin-3, 3'-digallate (TF3) is a black tea polyphenol produced from polymerization and oxidization of the green ployphenols epicatechin gallate (-)-epigallocatechin-3-gallate (EGCG) during fermentation fresh leaves. TF3 has been reported to have anticancer properties. However, effect on tumor angiogenesis underlying mechanisms are not clear. In present study, was verified inhibit angiogenesis. Compared with EGCG, more potent. inhibited human ovarian carcinoma OVCAR-3 cell-induced in...