A5100368911- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Meningioma and schwannoma management
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- RNA Interference and Gene Delivery
- Pituitary Gland Disorders and Treatments
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
Hunan Normal University
2020-2025
Anhui Medical University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2025
Shandong First Medical University
2014-2025
Shandong Tumor Hospital
2014-2025
Chongqing Medical University
2016-2025
Fudan University
1997-2025
Second Affiliated Hospital of Chongqing Medical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Karolinska Institutet
2001-2025
Abstract Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic years before conventional diagnosis in a longitudinal study. In Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored occurrence. Here we report preliminary results of PanSeer, noninvasive blood based on circulating tumor DNA methylation, TZL from 605 individuals, 191 whom later...
There is an urgent need for a vaccine that effective against the 2009 pandemic influenza A (H1N1) virus.
Abstract N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the of m6A macrophages are still unknown. Here, we discover ablation Mettl3 myeloid cells promotes tumour growth and metastasis vivo. In contrast wild-type mice, Mettl3-deficient mice show increased M1/M2-like tumour-associated macrophage regulatory T cell infiltration into tumours. sequencing reveals loss METTL3 impairs YTHDF1-mediated...
Abstract Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents reduce have not yielded success. Metabolic reprogramming is key hallmark confers several tumor phenotypes including chemoresistance. Glucose metabolic events 5-FU CRC has been evaluated, whether abnormal glucose metabolism could impart also poorly defined. Methods Three separate acquired cell line models were generated, was assessed...
Background and Objective Yes-associated protein (YAP) transcriptional co-activator with PDZ-binding motif (TAZ) are nuclear effectors of the Hippo pathway. Although they abundantly expressed in cytoplasm nuclei human colorectal cancer (CRC), related to tumor proliferation status, there have been few studies on predictive role YAP TAZ expression overall survival patients CRC. This study investigated both CRC colon cell lines, assessed their prognostic value. Methods Paraffin-embedded...
The impact of corticosteroids on the risk organ damage in context clinical end points endorsed some systemic lupus erythematosus (SLE) trials is underexplored.We analysed data from Hopkins Lupus Cohort using Cox proportional hazards models to understand exposure different corticosteroid doses developing any new or at individual systems over time.Mean prior prednisone dose, recent disease activity and immunosuppressant use during follow-up, as well score cohort entry, were significant...
Abstract Delayed wound healing has a profound impact on patients, healthcare, and society. Platelet‐rich plasma (PRP) gel, as preparation for regenerative medicine, proven to be of clinical value in various treatments. Nevertheless, its weak mechanical properties consequent burst release effect have restricted application efficacy. Here, an engineered PRP dual‐network hydrogel (named DN gel) based sodium alginate is constructed through simple “one‐step” activation process. Its improved...
Cancer-associated fibroblasts (CAFs) are critically involved in gemcitabine (GEM) resistance pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which CAFs promote chemotherapy remains unexplored. Here, we explored role of circRNAs CAF-induced GEM PDAC. circRNA sequencing and quantitative real-time PCR (qRT-PCR) were utilized to screen CAF-specific circRNAs. The effects CAF circFARP1 expression on tumor cells assessed vitro vivo. RNA-seq, RNA pulldown,...
Background: Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity metabolic co-morbidities challenging.Obesity induced chronic inflammation including brain hallmark of via gut-brain axis.The objective this study was to develop garlic exosome-like nanoparticles (GaELNs) that inhibit systemic as well inflammatory activity reverse HFD in mice.Methods: GELNs were isolated administrated orally into fed mice.GaELNs fluorescent labeled for monitoring...
Objective Whether and how the PI3K-AKT pathway, a central node of metabolic homeostasis, is responsible for high-fat-induced non-alcoholic steatohepatitis (NASH) hepatocellular carcinoma (HCC) remain mystery. Characterisation AKT regulation in this setting will provide new strategies to combat HCC. Design Metabolite library screening disclosed that palmitic acid (PA) could activate AKT. In vivo vitro palmitoylation assay were employed detect palmitoylation. Diverse cell mouse models,...
OBJECTIVE—To provide reliable age- and region-specific estimates of the associations between diabetes major cardiovascular diseases death in populations from Asia-Pacific region. RESEARCH DESIGN AND METHODS—Twenty-four cohort studies Asia, Australia, New Zealand (median follow-up, 5.4 years) provided individual participant data 161,214 people (58% Asia) whom 4,873 had a history at baseline. The with risks coronary heart disease, stroke, cause-specific mortality during follow-up were...
Lowe syndrome, also known as oculocerebrorenal is caused by mutations in the X chromosome-encoded OCRL gene. The protein 51% identical to inositol polyphosphate 5-phosphatase II (5-phosphatase II) from human platelets over a span of 744 aa, suggesting that may be similar enzyme. We engineered construct cDNA encodes amino acids homologous platelet for expression baculovirus-infected Sf9 insect cells. This aa 264-968 protein. recombinant was found catalyze reactions carried out II. Thus...