A5082007505- Gut microbiota and health
- Extracellular vesicles in disease
- Physics of Superconductivity and Magnetism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Chalcogenide Semiconductor Thin Films
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Sphingolipid Metabolism and Signaling
- Dietary Effects on Health
- Quantum Dots Synthesis And Properties
- Magnetic and transport properties of perovskites and related materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Copper-based nanomaterials and applications
- Advanced Condensed Matter Physics
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Cholesterol and Lipid Metabolism
- Studies on Chitinases and Chitosanases
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Advancements in Battery Materials
University of Louisville
2018-2025
Soochow University
2025
EA Technology
2025
Guangzhou Medical University
2018-2024
Wuhan No.1 Hospital
2024
Sinopec (China)
2024
Mackay Memorial Hospital
2024
Dongguan People’s Hospital
2023
Southern Medical University
2023
Union Hospital
2023
Highlights•Plant exosome-like nanoparticles (ELNs) are taken up by gut bacteria•The lipid composition of ELNs determines uptake specific bacteria•ELN RNAs affect bacterial genes, notably affecting Lactobacillus production I3A•ELN-mediated I3A alterations IL-22 production, resulting in ameliorated colitisSummaryThe microbiota can be altered dietary interventions to prevent and treat various diseases. However, the mechanisms which food products modulate commensals remain largely unknown. We...
Abstract High-fat diet (HFD) decreases insulin sensitivity. How high-fat causes resistance is largely unknown. Here, we show that lean mice become resistant after being administered exosomes isolated from the feces of obese fed a HFD or patients with type II diabetes. altered lipid composition predominantly phosphatidylethanolamine (PE) in animals (L-Exo) to phosphatidylcholine (PC) (H-Exo). Mechanistically, intestinal H-Exo taken up by macrophages and hepatocytes, leading inhibition...
Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered exosomes released from the epithelial cells exposed to severe acute respiratory syndrome 2 (SARS-CoV-2) Nsp12 and Nsp13 (exosomesNsp12Nsp13). Mechanistically, exosomesNsp12Nsp13 are taken up by macrophages, leading activation nuclear factor κB (NF-κB) subsequent induction an array inflammatory cytokines. Induction tumor necrosis...
Plant exosomes protect plants against infection; however, whether edible plant can mammalian hosts infection is not known. In this study, we show that ginger exosome-like nanoparticles (GELNs) are selectively taken up by the periodontal pathogen Porphyromonas gingivalis in a GELN phosphatidic acid (PA) dependent manner via interactions with hemin-binding protein 35 (HBP35) on surface of P. gingivalis. Compared PA (34:2), (34:1) did interact HBP35, indicating degree unsaturation plays...
Background: Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity metabolic co-morbidities challenging.Obesity induced chronic inflammation including brain hallmark of via gut-brain axis.The objective this study was to develop garlic exosome-like nanoparticles (GaELNs) that inhibit systemic as well inflammatory activity reverse HFD in mice.Methods: GELNs were isolated administrated orally into fed mice.GaELNs fluorescent labeled for monitoring...
Abstract Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators metastasis that act by modulating their target genes. In this study, we found miR-143 miR-145 via common gene, MYO6 , to regulate epithelial–mesenchymal transition (EMT) inhibit metastasis. We determined were downregulated in GC, ectopic expression and/or inhibited GC cell migration Furthermore, was identified as direct...
Abstract Background Gastric cancer (GC) is one of the most common malignancies worldwide, particularly in China. DNA damage‐inducible transcript 4 (DDIT4) a mammalian target rapamycin inhibitor and induced by various cellular stresses; however, its critical role GC remains poorly understood. The present study aimed to investigate potential relationship underlying mechanism between DDIT4 development. Methods We used western blotting, real‐time polymerase chain reaction, immunohistochemical or...
Gastric intestinal metaplasia (IM) is common in the gastric epithelium of patients with chronic atrophic gastritis. CDX2 activation IM driven by reflux bile acids and following inflammation. But mechanism underlying how activate has not been fully explored.We performed microRNA (miRNA) messenger RNA (mRNA) profiling using microarray cells treated acids. Data integration miRNA/mRNA profiles gene ontology (GO) analysis bioinformatics was to detect potential miRNA-mRNA regulatory circuits....
Diet manipulation is the basis for prevention of obesity and diabetes. The molecular mechanisms that mediate diet-based insulin resistance are not well understood. Here, as proof-of-concept, ginger-derived nanoparticles (GDNP) were used studying underlying GDNP mediated high-fat diet induced resistance.
Diet and bile play critical roles in shaping gut microbiota, but the molecular mechanism underlying interplay with intestinal microbiota is unclear. Here, we showed that lemon-derived exosome-like nanoparticles (LELNs) enhance lactobacilli toleration to bile. To decipher mechanism, used Lactobacillus rhamnosus GG (LGG) as proof of concept show LELNs LGG resistance via limiting production Msp1 Msp3, resulting decrease accessibility cell membrane. Furthermore, found decline Msps protein levels...
Abstract The tumor microenvironment is reprogrammed by cancer cells and participates in all stages of progression. Neutral ceramidase a key regulator ceramide, the central intermediate sphingolipid metabolism. contribution neutral to reprogramming not well understood. Here, we find that deletion multiple breast models female mice accelerates growth. Our result show Ly6C + CD39 tumor-infiltrating CD8 T are enriched display an exhausted phenotype. Deletion myeloid vivo vitro induces exhaustion...
The critical current and structural properties of (Gd,Y)BaCuO tapes made by metal organic chemical vapor deposition (MOCVD) with Zr addition levels up to 30 at.% have been investigated. reduction in beyond the previously optimized level 7.5 was found be due deterioration (Gd,Y)Ba2Cu3Ox film. By a modified MOCVD process, enhanced densities achieved high addition, including 3.83 MA cm−2 15 Zr-added 1.1 μm thick film at 77 K zero magnetic field. Critical currents as 1072 A/12 mm reached field 3...
Critical current performances of state-of-the-art Zr-added (Gd, Y)BaCuO tapes have been investigated over a temperature range 20–77 K, in magnetic fields up to 9 T and wide angular field orientations. The peak critical that is commonly observed the orientation perpendicular tape BaZrO3 (BZO) containing superconducting found vanish at 30 K 1–9 T. While 15% was about 40% lower than 7.5% 77 pinning force values former were be 18–23% higher those latter 20–40 3–5 results from this study...
As Cpf1 cleaves double-stranded DNA in a staggered way, it can be used assembly. However, the cleavage was found to inaccurate, which may cause errors Here, sites were precisely characterized, where site on target strand around 22nd base relative protospacer adjacent motif site, but non-target affected by spacer length. When length 20 nt or longer, mainly cleaved 14th and 18th bases strand; otherwise, with shorter (i.e. 17-19 nt), after base, generating 8-nt sticky ends. With this finding,...
Clostridioides difficile (C. diff) is the leading cause of antibiotic-associated colitis. Here, we report that lemon exosome-like nanoparticles (LELNs) manipulated probiotics to inhibit C. diff infection (CDI). LELN-manipulated Lactobacillus rhamnosus GG (LGG) and Streptococcus thermophilus ST-21 (STH) (LELN-LS) decrease CDI mortality via an LELN-mediated increase in bile resistance gut survivability. LELN-LS treatment increases AhR ligands indole-3-lactic acid (I3LA) indole-3-carboxaldehyde...
Microglia modulate pro-inflammatory and neurotoxic activities. Edible plant-derived factors improve brain function. Current knowledge of the molecular interactions between edible microglial cell is limited. Here an alcohol-induced chronic inflammation model used to identify that novel target oat nanoparticles (oatN). Oral administration oatN inhibits improves memory function mice are fed alcohol. Mechanistically, ethanol activates dectin-1 mediated inflammatory pathway. OatN taken up by...
Previous studies proved that heavy metals could increase the risk of disease by acting on gut microbiota. Meanwhile, microbiota played important roles in detoxifying metals. However, response to and which microbes dominated this detoxification processes are still unclear. This study investigated difference high-fat-diet (HFD) normal-diet (ND) their effects arsenic (As), cadmium (Cd), lead (Pb) exposure. Results showed ND HFD was significantly different responded As, Pb, Cd exposure...
Critical current (Ic) values of 1384 A/12 mm, corresponding to a critical density 12.47 MA cm−2 and pinning force 374 GN m−3, have been achieved at 30 K, 3 T in the orientation field parallel c axis (B ∥ c) (Gd, Y)BaCuO tapes with 15 mol% Zr addition made by metal organic chemical vapor deposition (MOCVD). These show levels as high 453 m−3 K. An analysis properties 24–28 showed lack correlation between their currents Ic both 77 zero 1 c). However, strong was found It has also discovered that...
Abstract Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis other deadly infections. However, late steps leading to biosynthesis industrially important rifamycin SV B remain largely unknown. Here, we characterize a network reactions underlying SV, S, L, O, B. The two-subunit transketolase Rif15 cytochrome P450 enzyme Rif16 are found mediate, respectively, unique C–O bond formation...
MicroRNAs have emerged as essential regulators of various cellular processes. We identified the role and underlying mechanisms miR-2392 in gastric cancer (GC) metastasis. MiR-2392 was down-regulated GC cell lines tissues, overexpression significantly inhibited invasion metastasis vitro vivo MAML3 WHSC1 novel targets miR-2392, knockdown had same antimetastatic effect that cells. These effects were clinically relevant, low expression correlated with high poor survival patients GC. Furthermore,...
Extrachromosomal circular DNAs (eccDNAs) has been found to be widespread and functional in various organisms. However, comparative analyses of pre- post-infection virus are rarely known. Herein, we investigated the changes expression patterns eccDNA following infection with Bombyx mori cytoplasmic polyhedrosis (BmCPV) explore role viral infection. Circle-seq was used analyze eccDNAs midgut BmCPV-infected BmCPV-uninfected silkworms. A total 5508 were identified, sizes varying from 72 bp 17...