A5100369934- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Milk Quality and Mastitis in Dairy Cows
- Child Nutrition and Water Access
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Heavy Metal Exposure and Toxicity
- Clostridium difficile and Clostridium perfringens research
- CRISPR and Genetic Engineering
- Animal Diversity and Health Studies
- Dietary Effects on Health
Guangzhou Medical University
2020-2024
McGill University
2014-2021
City University of Hong Kong
2020
Previous studies proved that heavy metals could increase the risk of disease by acting on gut microbiota. Meanwhile, microbiota played important roles in detoxifying metals. However, response to and which microbes dominated this detoxification processes are still unclear. This study investigated difference high-fat-diet (HFD) normal-diet (ND) their effects arsenic (As), cadmium (Cd), lead (Pb) exposure. Results showed ND HFD was significantly different responded As, Pb, Cd exposure...
Human breast milk contains a diverse community of bacteria, but as microbiome studies have largely focused on mothers from high income countries where few women breastfeed to 6 months, the temporal changes in that occur during later lactation stages not been explored. For this cross-sectional study, microbiota samples Mam -Mayan living eight remote rural communities Western Highlands Guatemala were analyzed. All delivered vaginally and breastfed their infants for months. Breast 76 unrelated...
Abstract Background Horizontal Gene Transfer (HGT) is the process of transferring genetic materials between species. Through sharing materials, microorganisms in human microbiota form a network. The network can provide insights into understanding microbiota. Here, we constructed HGT networks from gut sequencing data and performed analysis to characterize Results We perform two typical datasets, 283-sample dataset Mother-to-Child 148-sample longitudinal inflammatory bowel disease (IBD)...
Human milk contains a diverse community of bacteria that are modified by maternal factors, but whether these or other factors similar in developing countries has not been explored. Our objective was to determine the microbiota age, BMI, parity, lactation stage, subclinical mastitis (SCM), and breastfeeding practices first 6 mo an indigenous population from Guatemala. For this cross-sectional study, Mam-Mayan mothers nursing infants aged <6 were recruited. Unilateral human samples collected...
Background: SCM is an asymptomatic inflammatory condition of the lactating breast associated with infant growth faltering. A milk Na/K ratio >0.6 current indicator for whereas in cows SCC considered ‘gold standard’. Our objective was to determine if potential biomarkers human (SCC, pro‐inflammatory cytokines) were at two stages lactation. Methods: Breast samples collected from 53 Mam‐Mayan women infants < 45d (early lactation) and 52 4‐6mo (late lactation). Inductively Coupled Plasma...
Introduction: Obesity, which is associated with gut microbiota dysbiosis, low-grade chronic inflammation and intestinal barrier dysfunction, can cause a variety of metabolic diseases. Phytochemical flavonoids have biological activities, among there may be safe effective anti-obesity solutions. Methods: We tested plant-derived flavonoid hesperidin fecal transplantation (FMT) to alleviate diet-induced obesity. High-fat diet (HFD)-fed mice were treated (100 200 mg/kg BW) FMT. Results: Results...
Background Human breast milk contains a diverse population of bacteria, but factors influencing the microbiota have not been described. Objective We explored if maternal age, BMI, stage lactation and infant feeding practices influenced bacterial communities in indigenous mothers western highlands Guatemala. Methods In this cross‐sectional study, unilateral samples were collected from Mam ‐Mayan women during early (5‐46d, n=33) or established (4‐6mo, n=43) lactation. Maternal BMI (exclusive,...
Background Little is known about the impact of SCM on immunological and mineral concentrations human breast milk. Our objective was to determine if minerals cytokines differed in mothers with without during 3 stages lactation. Methods Transitional milk (TM: 5‐17d, n=21), early mature (EMM: 18‐46d, n=32) (MM: 109‐187d, n=59) samples were collected from Mam ‐Mayan women. Inductively Coupled Plasma Mass Spectrometry used analyze concentration 13 (Na, K, Ca, Mg, Mn, Zn, Cu, Cr, Sr, Se, Rb, Fe,...
Background : Human breast milk is the normal source of minerals for infant growth, development and metabolic function up to 6 months, but little information available about how mineral concentrations vary throughout lactation in developing countries. Our objectives were compare between early (<45d) later (4‐6mo) periods, determine if varied with age within these two periods. Methods Inductively Coupled Plasma Mass Spectrometry was used analyze concentration 13 (Na, K, Ca, Mg, Mn, Zn, Cu,...
Background It is well known that certain maternal infections impair infant growth. Less clear whether subclinical asymptomatic breast inflammation during the first six months of lactation will also retard During mastitis, a common inflammatory condition lactating breast, tight epithelial junctions become “leaky” allowing for movement sodium and potassium, pro‐inflammatory cytokines, growth factors into milk via paracellular pathway. The objectives this longitudinal study were to: (1) to...