Bacterial infectious diseases, especially those caused by Gram-positive bacteria, have been seriously threatening human health. Preparation of a multifunctional system bearing both rapid bacterial differentiation and effective antibacterial effects is highly in demand, but remains severe challenge. Herein, we rationally designed successfully developed sequence aggregation-induced emission luminogens (AIEgens) with orderly enhanced D-A strength. Evaluation structure-function relationships...

Infections caused by multidrug resistant bacteria are still a serious threat to human health. It is of great significance explore effective alternative antibacterial strategies. Herein, carbon–iron oxide nanohybrids with rough surfaces (RCF) developed for NIR-II light-responsive synergistic therapy. RCF excellent photothermal property and peroxidase-like activity could realize therapy (PTT)/chemodynamic (CDT) in the biowindow improved penetration depth low power density. More importantly,...

Abstract Multifunctional antibacterial photodynamic therapy is a promising method to combat regular and multidrug‐resistant bacteria. In this work, eosin Y (EY)‐based polycations (EY‐QEGEDR, R = CH 3 or C 6 H 13 ) with versatile types of functional components including quaternary ammonium, photosensitizer, primary amine, hydroxyl species are readily synthesized based on simple ring‐opening reactions. the presence light irradiation, such polymers exhibit high efficiency against both...

Biomedical device-associated infection (BAI) is a great challenge in modern clinical medicine. Therefore, developing efficient antibacterial materials significantly important and meaningful for the improvement of medical treatment people's health. In present work, we developed strategy surface functionalization multifunctional applications. A functionalized polyurethane (PU, widely used biomedical material hernia repairing) (PU-Au-PEG) with inherent antifouling photothermal bactericidal...

Abstract Efficient antimicrobials are urgently needed for the treatment of bacterial biofilms due to their resistance traditional drugs. Photodynamic therapy (PDT) is a new strategy that has been used combat bacteria and biofilms. Cationic photosensitizers, particularly cationic photodynamic nanoagents, usually chosen enhance antimicrobial activity. However, positively charged nanoparticles (NPs) beneficial cellular internalization, which causes increased cell cytotoxicity. Herein,...

Cationic agents, such as ionic liquids (ILs)-based species, have broad-spectrum antibacterial activities. However, the mechanisms lack systematic and molecular-level research, especially for Gram-negative bacteria, which highly organized membrane structures. Here, we designed a series of flexible fluorescent diketopyrrolopyrrole-based liquid derivatives (ILDs) with various molecular sizes (1.95-4.2 nm). The structure-antibacterial activity relationships ILDs against Escherichia coli (E....

Abstract Delayed wound healing has a profound impact on patients, healthcare, and society. Platelet‐rich plasma (PRP) gel, as preparation for regenerative medicine, proven to be of clinical value in various treatments. Nevertheless, its weak mechanical properties consequent burst release effect have restricted application efficacy. Here, an engineered PRP dual‐network hydrogel (named DN gel) based sodium alginate is constructed through simple “one‐step” activation process. Its improved...

Because of the abuse antibiotics and threats antibiotic resistance, bacterial infection is still one most difficult issues to be resolved. Thus, it great significance explore novel antibacterial agents. In this paper, we investigated a type silica-coated gold-silver nanocages (Au-Ag@SiO2 NCs) as candidates. Their intrinsic characteristics photothermal property sustained release Ag ions were fully exploited for near-infrared (NIR)-induced combined anti-infective therapy. The broad-spectrum...

Cationic photosensitizers have good binding ability with negatively charged bacteria and fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT). However, cationic often display unsatisfactory transkingdom selectivity between mammalian cells pathogens, especially for eukaryotic fungi. It is unclear which biomolecular sites are more efficient damage, owing to the lack of systematic research same photosensitizer system. Herein, a series aggregation-induced...

A fluorescent Zn2+ sensor 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenol (HMQP) based on the 8-aminoquinoline platform has been synthesized. This displays high selectivity, sensitive fluorescence enhancement, strong binding ability, and ratiometric response to in Tris−HCl (50 mM, pH 7.54), THF−H2O (9:1, v/v). And an obvious color change between HMQP Zn2+−MQP− can be visually observed by naked eye. The composition of complex found 1:2 fluorescence/absorption titration further...

Berberine chloride, an AIE-active natural product, can be utilized as a highly efficient theranostic agent for cancer and bacteria.

Combating implant-associated infections is an urgent demand due to the increasing numbers in surgical operations such as joint replacements and dental implantations. Surface functionalization of implantable medical devices with polymeric antimicrobial antifouling agents efficient strategy prevent bacterial fouling associated infections. In this work, branched (GPEG GEG) were synthesized via ring-opening reaction involving gentamicin ethylene glycol species. Due their rich primary amine...

Nucleic acid (NA)-based therapy is proposed to address serious diseases such as cardiovascular (CVDs). Powerful NA delivery vehicles are essential for effective gene therapy. Herein, a novel type of vehicle, an unlockable core-shell nanocomplex (Hep@PGEA) with self-accelerating release, structurally designed. Hep@PGEA composed disulfide-bridged heparin nanoparticle (HepNP) core and low-toxicity PGEA cationic shell. In comparison NA, heparin, negatively charged polysaccharide macromolecule,...

Abstract Chemiluminescence (CL) is an emission phenomenon induced by chemical reaction. Different from the photoluminescence, CL free external excitation source, which expected to show great advantages such as higher signal‐to‐background ratio (SBR) in bioimaging, and deeper tissue penetration photodynamic therapy (PDT). This review introduces theoretical aspects of mechanism, classification, energy consideration chemiexcited/photoexcited states. Application bioimaging highlighted. In...

Abstract Nanotechnology enlightens promising antibacterial strategies while the complex in vivo infection environment poses a great challenge to rational design of nanoplatforms for safe and effective anti-infective therapy. Herein, biomimetic nanoplatform (EV-Pd-Pt) integrating electrodynamic Pd-Pt nanosheets natural ginger-derived extracellular vesicles (EVs) is proposed. The introduction EVs greatly endows EV-Pd-Pt with prolonged blood circulation without immune clearance, as well...

Abstract Multidrug‐resistant Pseudomonas aeruginosa (MDR‐ P. ) cannot be extirpated with any of the antipseudomonal antibiotics available in clinic because exhibit natural resistance to and form a stable biofilm. Biofilm formed by is leading cause bacterial keratitis which may corneal perforation even blindness. Antibacterial photodynamic therapy (aPDT) promising bactericidal method combatting drug‐resistant bacteria. Unfortunately, use broad‐spectrum aPDT that kills bacteria...

In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of multidrug-resistant (MDR) bacteria, which poses severe threat human life and globalized healthcare. Currently, development cycle new antibiotics cannot match ongoing MDR infection crisis. Therefore, novel strategies are required resensitize bacteria existing antibiotics. this study, cationic polysaccharide conjugates Dextran-graft-poly(5-(1,2-dithiolan-3-yl)-N-(2-guanidinoethyl)pentanamide)...

Abstract New preparation methods of vectors are the key to developing next generation biomacromolecule delivery systems. In this study, a controllable disulfide exchange polymerization was established obtain low‐toxicity and efficient bioreducible polyguanidines (mPEG 225 ‐ b ‐PSS n , =13, 26, 39, 75, 105) by regulating concentration activated nucleophiles reaction time under mild conditions. The relationship between degrees biocompatibility studied identify optimal polyguanidine mPEG 26 ....

Abstract The escalating issue of lung infections induced by multi‐drug resistant (MDR) bacteria is threatening human health. Thus, the development efficient drug delivery systems essential to eliminate MDR bacterial effectively. Herein, we designed inhalable drug‐loaded nano‐assemblies electrostatic interaction between negatively charged sodium alginate and a positively antibacterial polymer, quaternized polyethyleneimine (QPEI‐C 6 ), as well kind typical antibiotic for therapy infection,...

Catheter-induced infection is a severe problem in clinical practice, which induces significant morbidity, mortality and treatment costs. Therefore, there great requirement for developing antibacterial surfaces of catheter materials. In the present study, we develop strategy constructing self-adaptive with bacterium-triggered antifouling-bactericidal switching properties on polyurethane (PU) via surface-initiated atom-transfer radical polymerization (SI-ATRP). Polymer coating one hierarchical...

Abstract Nucleic acid‐based therapy specially needs a safe and robust delivery vector. Herein, novel fluorinated acid‐labile branched hydroxyl‐rich polycation (ARP‐F) is proposed for the flexible effective nanovector of different plasmids including reporter genes Cas9 plasmid. Acid‐responsive (ARP) with plentiful ortho ester linkages hydroxyl groups first synthesized via facile one‐pot ring‐opening polymerization, followed by decoration alkyl chains onto ARP to achieve ARP‐F. ARP‐F possesses...

Abstract Gene editing is a crucial and effective strategy to treat genetic diseases. Safe delivery vectors are specially required for efficient gene in vivo of CRISPR/Cas9 system. Interestingly, lactose, natural saccharide, can specifically bind asialoglycoprotein receptors, highly expressed on the surface hepatocellular carcinoma (HCC) cells. Herein, lactose‐derived branched cationic biopolymer (LBP) with plentiful reducible disulfide linkages hydroxyl groups proposed as potential vector...