A5027515470- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Hernia repair and management
- Diabetes Treatment and Management
- Photonic and Optical Devices
- Optical Network Technologies
- Liver Disease Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Pancreatic and Hepatic Oncology Research
- Venous Thromboembolism Diagnosis and Management
- Pelvic and Acetabular Injuries
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Cardiovascular Function and Risk Factors
- Abdominal Trauma and Injuries
- Semiconductor Lasers and Optical Devices
- Advanced Photonic Communication Systems
- Distributed and Parallel Computing Systems
- Abdominal Surgery and Complications
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Appendicitis Diagnosis and Management
- Energy, Environment, Economic Growth
Shandong Provincial QianFoShan Hospital
2020-2025
Shandong First Medical University
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Shandong Provincial Institute of Dermatology and Venereology
2025
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Southwest Medical University
2024
Shandong University
2007-2024
Education Department of Jiangxi Province
2024
Abstract Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents reduce have not yielded success. Metabolic reprogramming is key hallmark confers several tumor phenotypes including chemoresistance. Glucose metabolic events 5-FU CRC has been evaluated, whether abnormal glucose metabolism could impart also poorly defined. Methods Three separate acquired cell line models were generated, was assessed...
Dual-network conductive hydrogels have drawn wide attention in epidemic electronics such as sensors and electrodes because of their inherent low Young's modulus, high skin-compliance, tunable mechanical strength. However, it is still full challenges to gain a dual-network hydrogel with stretchability, hysteresis, skin-adhesive performance simultaneously. Herein, address this issue, novel (denoted PAa hydrogel) polyacrylamide the first network topologically entangled polydopamine secondary...
BACKGROUND Gastric cancer (GC) is associated with high mortality rates. Bile acids (BAs) reflux a well-known risk factor for GC, but the specific mechanism remains unclear. During GC development in both humans and animals, BAs serve as signaling molecules that induce metabolic reprogramming. This confers additional phenotypes, including ferroptosis sensitivity. Ferroptosis novel mode of cell death characterized by lipid peroxidation contributes universally to malignant progression. However,...
Abstract Tripartite motif-containing protein 7 (TRIM7), as an E3 ligase, plays important regulatory role in various physiological and pathological processes. However, the of TRIM7 gastric cancer (GC) is still undefined. Our study detected expression clinical specimens investigated effect molecular mechanism on GC progression through vitro vivo experiments. finding showed that was significantly downregulated GC, patients with high long overall survival. Both experiments dramatically...
Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) weighted gene co-expression network (WGCNA) explore shared mechanism between gastrointestinal disorders. Significant correlations were found these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), neuroticism (NE). MTAG identify 60 novel...
Constructing micro PPy wrinkles on the rGO/Alg fiber surface with strong interactions at interface endows excellent specific capacitance and cycling stability.
Abstract Background Alzheimer's disease (AD) is a neurodegenerative disorder distinguished by swift cognitive deterioration accompanied distinctive pathological hallmarks such as extracellular Aβ (β‐amyloid) peptides, neuronal neurofibrillary tangles (NFTs), sustained neuroinflammation, and synaptic degeneration. The elevated frequency of AD cases its proclivity to manifest at younger age present pressing challenge in the quest for novel therapeutic interventions. Numerous investigations...
This study was designed to clarify the function and potential mechanism of gentiopicroside (GPS) in regulating malignant progression gastric cancer (GC) through vitro cellular experiments vivo animal models. AGS HGC27 cells were divided into control group GPS treatment groups (50 µM 100 µM). Then, proliferation, colony formation, migration, invasion, apoptosis detected, respectively. Transmission electron microscope (TEM) used observe mitochondrial changes, membrane (MMP) determined using...
Although 5-fluorouracil (5-FU) is the primary chemotherapy treatment for colorectal cancer (CRC), its efficacy limited by drug resistance. Ferroptosis activation a promising 5-FU-resistant cells; however, potential therapeutic targets remain elusive. This study investigated ferroptosis vulnerability and dihydroorotate dehydrogenase (DHODH) activity using stable, CRC cell lines xenograft models. was characterized measuring malondialdehyde levels, assessing lipid metabolism peroxidation,...
Laparoscopic splenectomy (LS) has been considered as the standard approach to remove a normal-sized spleen, but it is facing technical challenges when applied splenomegaly. Hand-assisted laparoscopic technique was designed facilitate performance of difficult procedure. This study aimed evaluate efficacy and superiority hand-assisted (HALS) for splenomegaly.From November 1994 January 2006, 36 patients with splenomegaly (final spleen weight > 700 g) were treated operations in our hospital....
The aim of this randomized controlled study was to determine whether octreotide (OCT) or scopolamine butylbromide (SB) the more effective antisecretive drug controlling gastrointestinal (GI) symptoms due malignant bowel obstruction (MBO) caused by advanced ovarian cancer. Ninety-seven cancer patients with inoperable MBO were OCT 0.3 mg/day (OCT group, n = 48) SB 60 (SB 49) for 3 days through a continuous subcutaneous infusion. following parameters measured: episodes vomiting, nausea, dry...
The prognostic value of lymph node ratio (LNR) in pancreatic cancer remains controversial. In the current retrospective study, we assessed LNR on predicting survival postoperative patients with cancer.Medical records who underwent resection for department general surgery, Qilu Hospital, Shandong University were reviewed retrospectively. Demographic, clinicopathological, tumor-specific data, and histopathological reports collected. Univariate multivariate analyses performed.A total 83 mean...
This study was designed to explore the roles of CREB3L4 in pathogenesis and drug resistance hepatocellular carcinoma (HCC). The proliferation HCC lines determined presence over-expression silencing. Chromatin immunoprecipitation (ChIP) assay dual-luciferase reporter were performed screen potential target on mTORC1. Xenografted tumor model established define regulatory effects tumorigenesis. Then we evaluated chemosensitivity sorafenib treatment. significantly induced cell by modulating...
Background Delirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads escalated healthcare expenditures, extended hospital stays, enduring cognitive deterioration, all of which are acknowledged detrimental outcomes. Nonetheless, the current strategies for predicting managing remain constrained. Our aim was employ Mendelian randomization (MR) investigate potential causal relationship between metabolites delirium, as well...