A5011367505- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Liver Disease and Transplantation
- Minimally Invasive Surgical Techniques
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Cancer Mechanisms and Therapy
- Oral microbiology and periodontitis research
- Liver physiology and pathology
- Aldose Reductase and Taurine
- Biliary and Gastrointestinal Fistulas
- Animal Disease Management and Epidemiology
- Salivary Gland Disorders and Functions
- PI3K/AKT/mTOR signaling in cancer
- Advanced Glycation End Products research
- Intestinal and Peritoneal Adhesions
Chinese Academy of Sciences
2024-2025
Zhejiang Cancer Hospital
2023-2025
Zhejiang Chinese Medical University
2025
Hangzhou Xixi hospital
2025
Hangzhou Cancer Hospital
2025
University of Chinese Academy of Sciences
2023-2024
Shandong First Medical University
2024
Shandong Provincial QianFoShan Hospital
2022-2024
Shandong University
2019-2024
Harbin Veterinary Research Institute
2024
Previous studies demonstrated oxytocin treatment effectiveness in reducing mortality and reversing liver fibrosis mice. However, the underlying mechanism remains obscure, given absence of receptor expression hepatic stellate cells, primary effector cells.
Oxidative stress plays an important role in the pathogenesis of liver diseases. N-Acetyl-serotonin (NAS) has been reported to protect against oxidative damage, though mechanisms by which NAS protects hepatocytes from remain unknown. To determine whether pretreatment with could reduce hydrogen peroxide- (H2O2-) induced HepG2 cells inhibiting mitochondrial apoptosis pathway, we investigated H2O2-induced damage or without using MTT, Hoechst 33342, rhodamine 123, Terminal dUTP Nick End Labeling...
Abstract As a critical component of the tumour immune microenvironment (TIME), resident microbiota promotes tumorigenesis across variety cancer types. Here, we integrated multiple types omics data, including microbiome, transcriptome, and metabolome to investigate functional role intratumoral bacteria in gastric (GC). The microbiome was used categorize GC samples into six subtypes, patients with high abundance Streptococcus or Pseudomonas had markedly worse prognosis. Further assays revealed...
This study was designed to explore the roles of CREB3L4 in pathogenesis and drug resistance hepatocellular carcinoma (HCC). The proliferation HCC lines determined presence over-expression silencing. Chromatin immunoprecipitation (ChIP) assay dual-luciferase reporter were performed screen potential target on mTORC1. Xenografted tumor model established define regulatory effects tumorigenesis. Then we evaluated chemosensitivity sorafenib treatment. significantly induced cell by modulating...
Highlights•TUDCA alleviated atherosclerosis and promoted cholesterol efflux capacity of macrophages•TUDCA inhibited activation the PERK/eIF2α/ATF4 AIM2 inflammasome•ATF4 affected transcriptional activity AIM2•AIM2 mediated foam cell formation by targeting ABCA1SummaryCholesterol (CEC) dysfunction in macrophages is important atherosclerosis. However, mechanism underlying CEC remains unclear. We described characteristics ATF4 inflammasome during through scRNA sequencing analysis. Then model...
Suppressor of variegation, Enhancer Zeste, Trithorax and Myeloid-Nervy-DEAF1 domain-containing (SMYD) proteins are a set lysine methyltransferases involved in range diverse biological functions, including gene expression, regulation skeletal cardiac-muscle development. These may additionally serve roles number different types cancer. However, the five SMYD proteins, 1/2/3/4/5, their expression patterns prognostic value remain unclear. In present study, transcriptional levels were compared...
Body mass index (BMI) is considered an important factor in tumor prognosis, but its role gastric cancer (GC) remains controversial. There a lack of studies exploring the effect BMI on from perspective intratumoral microbiota. This study aimed to compare and analyze differences functions microbiota among GC patients with varying BMIs, aiming ascertain whether specific microbial features are associated prognosis low-BMI (LBMI) patients. A retrospective analysis clinicopathological 5567...
Introduction Accurate diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV patients remains challenging. This study compares metagenomic next-generation sequencing (mNGS) with PCR, GMS staining, and serum β-D-glucan (BG) assays for PJP detection co-infection identification. Methods BALF samples from 34 HIV-positive 50 non-PJP controls were analyzed. Diagnostic performance metrics (sensitivity, specificity, NPV, AUC) co-pathogen profiles evaluated mNGS versus conventional methods....
Digestive system tumours (DSTs) often diagnosed late due to nonspecific symptoms. Non-invasive biomarkers are crucial for early detection and improved outcomes. We collected tongue coating samples from 710 patients with DST 489 healthy controls (HC) April 2023, December 2023. Microbial composition was analyzed using 16S rRNA sequencing, five machine learning algorithms were applied assess the diagnostic potential of microbiota. Alpha diversity analysis showed that microbial in significantly...
To determined KIAA1199 expression and investigate its correlation with the clinicopathologic data prognosis of hepatocellular carcinoma (HCC), as well markers epithelial-mesenchymal transition (EMT); N-cadherin, E-cadherin vimentin.Western blot, quantitative real-time PCR, immunohistochemical staining were used to measure in human HCC specimens. Subsequently, between pathological characteristics patients was analyzed. Univariate multivariate analyses explore risk factors associated...
The purpose of this study was to investigate the possible protective effect N-acetylserotonin (NAS) against acute hepatic ischemia-reperfusion (I/R) injury in mice. Adult male mice were randomly divided into three groups: sham, I/R, and I/R + NAS. model generated by clamping artery, portal vein, common bile duct with a microvascular bulldog clamp for 30 min, then removing allowing reperfusion 6 h. Morphologic changes hepatocyte apoptosis evaluated hematoxylin-eosin (HE) terminal...
To explore a simple and easy-to-learn procedure for the isolation of human quiescent hepatic stellate cells (HSCs) that requires no advanced training. Thus reducing costs increasing efficiency. This protocol will provide sufficient primary with minimal contaminants future basic research on diseases associated HSCs. Normal liver tissues were isolated from patients undergoing hemangioma resection, single cell suspension these was prepared using Gentle MACS tissue processor. By this method,...
To describe the surgical procedures of laparoscopic caudate lobectomy and analyze its clinical efficiency for treating cancer.Twelve consecutive patients hepatocellular carcinoma, hepatic hemangioma, focal nodular hyperplasia who received in Qilu Hospital Shandong University from January 2013 to 2017 were included this study. The data, intraoperative parameters, postoperative outcomes assessed.All 12 totally technique. operative time was 140.8 ± 95.34 minutes. average estimated blood loss...
Cell proliferation and migration are the determinants of malignant tumor progression, a better understanding related genes will lead to identification new targets aimed at preventing spread cancer. Some studies have shown that KIAA1199 (CEMIP) is transmembrane protein expressed in many types noncancerous cells cancer cells. However, potential role progression cholangiocarcinoma (CCA) remains unclear.Analysis cancer-related databases showed overexpressed CCA. ELISA, immunohistochemistry,...
The aim of the present study was to identify differentially-expressed genes embryonic day 14 (ED 14) rat liver in comparison adult liver, which may provide specific information for investigation hepatogenesis mechanism. gene expression profiles ED and livers were investigated using microarray analysis (the Illumina RatRef-12 Expression BeadChip). Quantitative polymerase chain reaction (qPCR) analyses conducted confirm expression. There 787 upregulated liver. Based on ontology classification...
Inflammation is one of the most crucial mechanism underlying hepatic ischemia-reperfusion injury (HIRI). Several studies have shown that Ac2-26, active N-terminal peptide Annexin A1, could modulate anti-inflammatory processes and protect organs from (IRI). However effects Ac2-26 on an HIRI model not been reported to date. The purpose present study was determine whether pretreatment hepatocytes against acute by inhibiting neutrophil infiltration through regulation high mobility group box...