A5100697022- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Trace Elements in Health
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Flavonoids in Medical Research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Distributed Control Multi-Agent Systems
- Inflammasome and immune disorders
- Natural Antidiabetic Agents Studies
- Biochemical Acid Research Studies
- Toxin Mechanisms and Immunotoxins
Shenyang University of Chemical Technology
2025
Sichuan University
2022-2025
Jiaozuo University
2024
Qingdao University
2023-2024
Affiliated Hospital of Qingdao University
2023-2024
Johnson University
2014-2021
Rutgers, The State University of New Jersey
2012-2021
Mudanjiang Medical University
2021
Shandong University
2012-2020
Beijing Tian Tan Hospital
2020
// Xin Yu 1,2,* , Adam R. Blanden 3,* Sumana Narayanan 2 Lalithapriya Jayakumar David Lubin 3 Augeri 4 S. Kimball Stewart N. Loh and Darren Carpizo 1,2 1 Rutgers Cancer Institute of New Jersey, Jersey Department Surgery, Robert Wood Johnson Medical School, Brunswick, Biochemistry Molecular Biology, SUNY Upstate University, Syracuse, York Medicinal Chemistry, Ernest Mario School Pharmacy, Piscataway, * These authors contributed equally to this work Correspondence: Loh, email: Carpizo,...
Abstract TLRs are key sensors for conserved bacterial molecules and play a critical role in host defense against invading pathogens. Although the roles of pathogen infection maintaining gut immune homeostasis have been studied, precise functions different response to remain elusive. The present study investigated TLR signaling Gram-negative Salmonella typhimurium. results indicated that TLR9-deficient mice were more susceptible S. typhimurium compared with wild-type TLR2- or TLR4-deficient...
Emerging evidence indicates that gamma-aminobutyric acid (GABA) has many beneficial effects such as ameliorating immune and inflammatory response. But, here we reported activation of GABAA Rs aggravated dextran sodium sulfate (DSS)-induced colitis although the expression pro-inflammatory cytokines was inhibited. In contrast, blocking markedly alleviated DSS-induced colitis. Notably, GAD 65/67 were significantly increased in colon mucosa UC patients mouse model Further studies showed GABA...
Research shows a higher incidence of colorectal cancer in men. However, the molecular mechanisms for this gender disparity remain unknown. We report roles androgen proliferation and differentiation intestinal stem cells via targeting receptor (AR) on stromal by negatively regulating BMP signaling. Orchidectomy (ORX) or AR antagonist promotes expansion epithelium but suppresses cell (ISC) proliferation. Conversely, agonist inhibits ISC augments ovariectomized mice. Mechanistically, activation...
Melanoma is the deadliest form of commonly encountered skin cancer, and has fast propagating highly invasive characteristics. Pim-3, a expressed oncogene in melanoma, conserved serine/threonine kinase with various biological activities, such as proliferation-accelerating anti-apoptosis effects on cancer progression. However, whether Pim-3 regulates melanoma metastasis not been determined. Here, we constructed Pim-3–silencing short hairpin RNA (sh-Pim-3), TLR7-stimulating ssRNA dual-function...
We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using mechanism called zinc metallochaperones (ZMCs) restore binding by shuttling into cells. defined biophysical and cellular assays necessary for structure–activity relationship studies this mechanism. investigated an alternative class scaffolds differ from TSCs substitution the thiocarbamoyl moiety with benzothiazolyl, benzoxazolyl, benzimidazolyl hydrazones. Members...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic, stiff tumor microenvironment (TME), where tumor-associated macrophages (TAMs) drive ECM remodeling, progression, and immune evasion. The contribution of mechanical cues to monocyte differentiation into TAMs remains largely unexplored. Here we show that force required for monocyte-to-macrophage differentiation. PYK2, as an innovative immunomechanical checkpoint, de facto governs this process. We demonstrated PYK2...
MicroRNAs, small non-encoding RNAs that post-transcriptionally modulate expression of their target genes, have been implicated as critical regulatory molecules in endothelial cells.In the present study, we found overexpression miR-19a protects cells from lipopolysaccharide (LPS)-induced apoptosis through signal-regulating kinase 1 (ASK1)/p38 pathway. Quantitative real-time PCR demonstrated cell was markedly down-regulated by LPS stimulation. Furthermore, LPS-induced significantly inhibited...
Microtubule-associated protein tau is closely correlated with hypometabolism in Alzheimer's disease (AD). α-lipoic acid (LA), which a naturally occurring cofactor mitochondrial, has been shown to have the properties can inhibit pathology and neuronal damage our previous research. However, if LA effect on glucose metabolism when it reverses remains unclear, especially respect potential mechanism. Therefore, we make further study using P301S mouse model (a tauopathy AD overexpressing...
Lethal intestinal tissue toxicity is a common side effect and dose-limiting factor in chemoradiotherapy. Chemoradiotherapy can trigger DNA damage induce P53-dependent apoptosis LGR5+ stem cells (ISCs). Gamma-aminobutyric acid (GABA) its A receptors (GABAAR) are present the gastrointestinal tract. However, functioning of GABAergic system ISCs poorly defined. We found that GABAAR α1 (GABRA1) levels increased murine intestine after GABRA1 depletion protected from chemoradiotherapy-induced...
Baicalein, a type of flavonoids extracted from Scutellaria baicalensis Georgi, has been reported to be very promising drug for pancreatic cancer. However, it is unclear whether combination baicalein with gemcitabine or docetaxel synergistic the treatment cancer (PC). We investigated combinational effects on proliferation, cell cycle, migration and apoptosis human PC cells. Administration alone significantly inhibit proliferation Notably, when combined docetaxel, index (CI) values calculated...
Cell proliferation and migration are the determinants of malignant tumor progression, a better understanding related genes will lead to identification new targets aimed at preventing spread cancer. Some studies have shown that KIAA1199 (CEMIP) is transmembrane protein expressed in many types noncancerous cells cancer cells. However, potential role progression cholangiocarcinoma (CCA) remains unclear.Analysis cancer-related databases showed overexpressed CCA. ELISA, immunohistochemistry,...
Glioma is among the most common primary brain tumors and one of aggressive lethal forms human cancer. Long noncoding RNAs (lncRNAs) have demonstrated great importance in development progression The present study aimed to investigate role novel tumor suppressive lncRNA on Chromosome 8p12 (TSLNC8), cell proliferation, metastasis apoptosis glioma. It was initially reported that relative transcript levels TSLNC8 were significantly decreased glioma tissues cultured cells, as evidenced by RT‑qPCR....
Carboxymethyl chitosan has the potential to be used in field of hemostatic materials, but its low molecular weight and high water solubility limit application. This study prepared crosslinked carboxymethyl by crosslinking reaction with glutaraldehyde determined physicochemical properties, FT-IR spectra, toxicity cell morphology on L929 fibroblasts. The effect healing function rat liver were also evaluated. animals divided into three groups ( n = 18): control group (Con), Surgicel® (Sur),...
The intestinal immune system is crucial for protection from pathogenic infection and maintenance of mucosal homeostasis. We studied the microenvironment in a Salmonella enterica serovar Typhimurium mouse model. Intestinal lamina propria macrophages are main effector cells innate resistance to intracellular microbial pathogens. found that S augmented Tim-3 expression on CD4+ T enhanced galectin-9 F4/80+ CD11b+ macrophages. Moreover, promoted activation bactericidal activity via...
Diabetic nephropathy (DN) affects around 40% of people with diabetes, the final outcome which is end-stage renal disease. The deficiency autophagy and excessive oxidative stress have been found to participate in pathogenesis DN. Sinensetin (SIN) has proven strong antioxidant capability. However, effect SIN on DN not studied. We examined cell viability podocyte line, MPC5 cells, treated high glucose (HG). For vivo studies, mice models were established by intraperitoneal injected...