A5065516495- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
Northwest A&F University
2022
First Affiliated Hospital of Guangzhou Medical University
2022
State Key Laboratory of Respiratory Disease
2022
Guangzhou Medical University
2022
Autophagy plays an important role in the pathogenesis of pulmonary hypertension (PH). ROC-325 is a novel small molecule lysosomal autophagy inhibitor that has more potent anticancer activity than antimalarial drug hydroxychloroquine, latter been prevalently used to inhibit autophagy. Here, we sought determine therapeutic benefit and mechanism action experimental PH models.Hemodynamics, echocardiography, histology measurement showed treatment prevented development PH, right ventricular...
Background. Pulmonary arterial hypertension (PAH) is a complex pulmonary vasculature disease characterized by progressive obliteration of small arteries and persistent increase in vascular resistance, resulting right heart failure death if left untreated. Artemisinin (ARS) its derivatives, which are common antimalarial drugs, have been found to possess broad range biological effects. Here, we sought determine the therapeutic benefit mechanism ARS derivatives treatment experimental (PH)...