A5100692340- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Platelet Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Obstructive Sleep Apnea Research
- Cancer Genomics and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Natural Compounds in Disease Treatment
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Reproductive System and Pregnancy
- Atrial Fibrillation Management and Outcomes
- Cancer-related gene regulation
- Medicinal Plant Pharmacodynamics Research
- Hemoglobinopathies and Related Disorders
- Polyomavirus and related diseases
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Organ Transplantation Techniques and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- ECG Monitoring and Analysis
Zhujiang Hospital
2021-2024
Southern Medical University
2021-2024
Chinese PLA General Hospital
2003-2023
Qingdao Municipal Hospital
2023
Zhejiang Chinese Medical University
2021-2023
Qingdao University
2023
Hainan General Hospital
2020-2022
Southwest University
2021-2022
Guangzhou Medical University
2022
First Affiliated Hospital of Guangzhou Medical University
2022
Ferroptosis is a recently identified iron‐dependent form of nonapoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles iron metabolism ferroptosis remain poorly understood. Here, we studied functional role pathogenesis ferroptosis. We found that ferric citrate potently induces murine primary hepatocytes bone marrow–derived macrophages. Next, screened for mice fed high‐iron diet mouse models hereditary hemochromatosis with overload. occurred two...
Rationale: Single-cell RNA sequencing (scRNA-seq) has provided an unbiased assessment of specific profiling cell populations at the single-cell level. Conventional renal biopsy and bulk RNA-seq only average out underlying differences, while extent chronic kidney transplant rejection (CKTR) how it is shaped by cells states in remain poorly characterized. Here, we analyzed from CKTR matched healthy adult kidneys resolution. Methods: High-quality transcriptomes were generated three human two...
Autophagy plays an important role in the pathogenesis of pulmonary hypertension (PH). ROC-325 is a novel small molecule lysosomal autophagy inhibitor that has more potent anticancer activity than antimalarial drug hydroxychloroquine, latter been prevalently used to inhibit autophagy. Here, we sought determine therapeutic benefit and mechanism action experimental PH models.Hemodynamics, echocardiography, histology measurement showed treatment prevented development PH, right ventricular...
The incidence of acute kidney injury (AKI) is on the rise and associated with high mortality; however, there are currently few effective treatments. Moreover, relationship between Tregs other components immune microenvironment (IME) in pathogenesis AKI remains unclear. We downloaded four publicly accessible datasets, GSE61739, GSE67401, GSE19130, GSE81741, GSE19288 GSE106993 from gene expression omnibus (GEO) database. Additionally, we gathered two single-cell sequencing (scRNA-seq) samples...
Kidney transplantation is currently the first choice of treatment for various types end-stage renal failure, but there are major limitations in application immunosuppressive protocols after kidney transplantation. When dose immunosuppressant too low, graft rejection occurs easily, while a that high can lead to loss. Therefore, it very important explore immune status patients receiving agents To compare recipient’s whole peripheral blood before and receipt agents, we used single-cell...
Background and Objective: The 6-min walk test (6MWT) is a common functional assessment test, but adverse events during the can be potentially dangerous lead to serious consequences low quality of life. This study aimed predict occurrence 6MWT, using continuous physiological parameters combined with demographic variables. Methods: 578 patients respiratory disease who had performed standardized 6MWT wearable devices from three hospitals were included in this study. Adverse occurred 73 (12.6%)....
The neuroprotective effects of Bu-Wang-San (BWS) and its on spine synapse plasticity were investigated in ovariectomised rats.Thirty-six rats divided into three groups: untreated controls, treatment with 17beta-estradiol or BWS. After 3 months, spatial acquisition retention measured using the Morris water maze. Swim time, swim distance, speed, quadrant time platform crossing recorded. Spine density hippocampus was examined by transmission electron microscopy. expression synaptophysin P38...
Acquired aplastic anemia (AA) is a bone marrow failure disorder characterized by pancytopenia, and immunosuppressive therapy (IST) the optional first-line management. Several studies identified influencing factors on IST response; however, there are still considerable number of patients suffering from poor prognoses. In this study, we enrolled 61 AA aged ≤ 40 years old, whole-exome sequencing (WES) found unexpected high FANC heterozygous germline mutations (28/61, 45.9%). Patients with have...
Objectives The selection and timing of anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) or allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with transfusion-dependent non-severe aplastic anemia (TD-NSAA) pose significant clinical challenges. This study aims to compare the efficacy long-term outcomes two treatments TD-NSAA.
In a previously published clinical trial, we demonstrated that tirofiban was effective and safe in acute ischemic stroke (AIS) patients who did not undergo early recanalization treatments. We aimed to evaluate neuroimaging characteristics their significance guide treatment. this post hoc analysis, location of infarcts (anterior circulation [ACS] vs. posterior [PCS]), degree cerebral artery stenosis (≤69% ≥70% or occlusion), total infarct volume, ASPECTS were used predict the treatment...
Abstract Objectives The neuroprotective effects of Bu-Wang-San (BWS) and its on spine synapse plasticity were investigated in ovariectomised rats. Methods Thirty-six rats divided into three groups: untreated controls, treatment with 17β-estradiol or BWS. After 3 months, spatial acquisition retention measured using the Morris water maze. Swim time, swim distance, speed, quadrant time platform crossing recorded. Spine density hippocampus was examined by transmission electron microscopy....
Anti-thymoglobulin (ATG)-based immunosuppressive treatment (IST) is the standard first-line management for patients with severe AA/very AA (SAA/VSAA) and not suitable allogeneic stem cell transplantation. The response predictor was fully investigated.The present study attempted to explore other characteristics, such as serum lipid changes, during ATG-based IST analyzed their significance in predicting survival.A total of 61 newly diagnosed SAA/VSAA who received were enrolled from January...
Pulmonary rehabilitation has been demonstrated as a highly effective and safe treatment for improving health-related quality of life reducing hospital admissions mortality in chronic obstructive pulmonary disease (COPD) patients. Despite significant progress within the physiological monitoring device industry, widespread integration wearable systems into medical practice remains limited. In this paper, we present medical-grade multi-sensor system to acquire COPD patients' vital signs assist...