A5004634878- Pulmonary Hypertension Research and Treatments
- Lymphatic System and Diseases
- Cancer, Hypoxia, and Metabolism
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Sympathectomy and Hyperhidrosis Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Renal Transplantation Outcomes and Treatments
- Eicosanoids and Hypertension Pharmacology
- Proteoglycans and glycosaminoglycans research
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Circadian rhythm and melatonin
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Nitric Oxide and Endothelin Effects
- Neonatal Respiratory Health Research
- Systemic Sclerosis and Related Diseases
- Congenital Diaphragmatic Hernia Studies
- Diagnosis and Treatment of Venous Diseases
Stanford University
2015-2025
VA Palo Alto Health Care System
2014-2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Guangdong Medical College
2024
Palo Alto University
2021-2024
Palo Alto Veterans Institute for Research
2024
Pulmonary and Critical Care Associates
2020
Creative Commons
2019
China Medical University
2019
Pulmonary arterial hypertension (PAH) is an incurable disease associated with viral infections and connective tissue diseases. The relationship between inflammation pathogenesis in these disorders remains poorly understood. To determine whether immune dysregulation due to absent T-cell populations directly contributes the development of PAH. Vascular endothelial growth factor receptor 2 (VEGFR2) blockade induced significant pulmonary apoptosis T-cell-deficient rats but not...
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-aged women, its etiology poorly understood. A prominent pathological feature of PH accumulation macrophages near the arterioles lung. In both clinical tissue SU5416 (SU)/athymic rat model severe PH, we found accumulated expressed high levels leukotriene A4 hydrolase (LTA4H), biosynthetic enzyme for B4 (LTB4). Moreover, macrophage-derived LTB4 directly induced apoptosis in pulmonary artery endothelial...
Lymphedema is a common debilitating condition with very limited treatment options, and leukotriene B 4 may be key pathogenic molecule therapeutic target.
Pulmonary arterial hypertension (PAH) is a life-threatening disorder of the pulmonary circulation associated with loss and impaired regeneration microvessels. Reduced pericyte coverage microvessels pathological feature PAH caused partly by inability pericytes to respond signaling cues from neighboring microvascular endothelial cells (PMVECs). We have shown that activation Wnt/planar cell polarity pathway required for recruitment, but whether production release specific Wnt ligands PMVECs are...
BACKGROUND. Lymphedema is a common condition affecting millions around the world that still lacks approved medical therapy. Because ketoprofen, an NSAID, has been therapeutic in experimental lymphedema, we evaluated its efficacy humans.
Abstract Vascular remodeling is the process of structural alteration and cell rearrangement blood vessels in response to injury cause many world’s most afflicted cardiovascular conditions, including pulmonary arterial hypertension (PAH). Many studies have focused on effects vascular endothelial cells smooth muscle (SMCs) during remodeling, but pericytes, an indispensable population residing largely capillaries, are ignored this maladaptive process. Here, we report that hypoxia-inducible...
Chronic rejection, manifested as small airway fibrosis (obliterative bronchiolitis [OB]), is the main obstacle to long-term survival in lung transplantation. Recent studies demonstrate that airways involved a transplant are relatively hypoxic at baseline and OB pathogenesis may be linked ischemia induced by transient loss of microvasculature. Here, we show HIF-1α mediates microvascular repair model orthotopic tracheal Grafts with conditional knockout Hif1a demonstrated diminished recruitment...
A recent study demonstrated a significant role for leukotriene B4 (LTB4) causing pulmonary vascular remodeling in arterial hypertension. LTB4 was found to directly injure luminal endothelial cells and promote growth of the smooth muscle cell layer arterioles. The purpose this determine effects on adventitial layer, largely composed fibroblasts. Here, we demonstrate that enhanced human artery fibroblast proliferation, migration, differentiation dose-dependent manner through its cognate...
Background: Bmpr2 (bone morphogenetic protein receptor 2) mutations are critical risk factors for hereditary pulmonary arterial hypertension (PAH) with approximately 20% of carriers developing disease. There is an unmet medical need to understand how environmental factors, such as inflammation, render mutants susceptible PAH. Overexpressing 5-LO (5-lipoxygenase) provokes lung inflammation and transient PAH in +/ - mice. Accordingly, its metabolite, leukotriene B 4 , candidates the second...
Pulmonary artery smooth muscle cells (PASMCs) and pericytes are NG2+ mural that provide structural support to pulmonary arteries capillaries. In arterial hypertension (PAH), both cell types contribute PA muscularization, but whether similar mechanisms responsible for their behavior is unknown. RNA-seq was used compare the gene profile of PASMCs from PAH healthy lungs. NG2-Cre-ER mice were generate NG2-selective reporter (NG2tdT) lineage identification tamoxifen-inducible SDF1 knockout...
Hypoxia-inducible factors (HIFs), especially HIF-1α and HIF-2α, are key mediators of the adaptive response to hypoxic stress play essential roles in maintaining lung homeostasis. Human animal genetics studies confirm that abnormal HIF correlates with pulmonary vascular pathology chronic diseases, but it remains unclear whether endothelial cell production is for microvascular health. The large airway has an ideal circulatory bed evaluating histological changes physiology genetically modified rodents.
BACKGROUND: Pathogenic concepts of right ventricular (RV) failure in pulmonary arterial hypertension focus on a critical loss microvasculature. However, the methods underpinning prior studies did not take into account 3-dimensional (3D) aspects cardiac tissue, making accurate quantification difficult. We applied deep-tissue imaging to pressure-overloaded RV uncover 3D properties microvascular network and determine whether deficient adaptation contributes failure. METHODS: Heart sections...
Increased ferric iron in allografts triggers a switch the growth of mold Aspergillus fumigatus from colonizing to an invasive phenotype.
Rationale: Endothelial injury may provoke emphysema, but molecular pathways of disease development require further discernment. Emphysematous lungs exhibit decreased expression HIF-2α (hypoxia-inducible factor-2α)-regulated genes, and tobacco smoke decreases pulmonary concentrations. These findings suggest that is important in the emphysema.Objectives: The objective this study was to evaluate roles endothelial-cell (EC) pathogenesis emphysema mice.Methods: Mouse were examined for after...