A5020792039- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Organ Transplantation Techniques and Outcomes
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Renal Transplantation Outcomes and Treatments
- Mesenchymal stem cell research
- Cardiac Arrest and Resuscitation
- Cardiac Fibrosis and Remodeling
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Elasticity and Material Modeling
- Cardiac tumors and thrombi
- Tracheal and airway disorders
Stanford University
2016-2025
Stanford Medicine
2020-2024
Palo Alto University
2021-2024
Stanford Health Care
2022
John D. and Catherine T. MacArthur Foundation
2013-2022
University of Pennsylvania
2011-2020
Cardiovascular Research Center
2011-2017
Hospital of the University of Pennsylvania
2013-2015
Osaka University
2013
Emory University
2011
Clinical percutaneous delivery of synthetically engineered hydrogels remains limited due to challenges posed by crosslinking kinetics—too fast leads failure, too slow limits material retention. To overcome this challenge, supramolecular assembly is exploited localize at the injection site and introduce subsequent covalent control final properties. Supramolecular gels are designed through separate pendant modifications hyaluronic acid (HA) guest–host pair cyclodextrin adamantane, enabling...
Solar-powered heart? Harnessing light to create myocardial renewable energy.
Exogenously delivered chemokines have enabled neovasculogenic myocardial repair in models of ischemic cardiomyopathy; however, these molecules short half-lives vivo. In this study, we hypothesized that the sustained delivery a synthetic analog stromal cell-derived factor 1-α (engineered [ESA]) induces continuous homing endothelial progenitor cells and improves left ventricular function rat model infarction.Our previously designed ESA peptide was synthesized by addition fluorophore tag for...
Background Continuous flow left ventricular assist devices (CF LVAD) are being implanted with increasing frequency for end-stage heart failure. At the time of LVAD implant, a large proportion patients have pulmonary hypertension, right (RV) dysfunction, and tricuspid regurgitation (TR). RV dysfunction TR can exacerbate renal hepatic coagulopathy, edema, even prohibit isolated implant. Repairing mandates increased cardiopulmonary bypass bicaval cannulation, which should be reserved orthotopic...
Importance The use of ex vivo normothermic organ perfusion has enabled the deceased after circulatory death (DCD) donors for heart transplants. However, compared with conventional brain donation, DCD transplantation performed involves an additional period warm and cold ischemia, exposing allograft to multiple bouts ischemia reperfusion injury may contribute high rates extracorporeal membrane oxygenation usage transplantation. Objective To assess whether beating method is safe it acceptable...
Background— Neuregulin-1β (NRG) is a member of the epidermal growth factor family possessing critical role in cardiomyocyte development and proliferation. Systemic administration NRG demonstrated efficacy cardiomyopathy animal models, leading to clinical trials using daily infusions. This approach hindered by requiring infusions off-target exposure. Therefore, this study aimed encapsulate hydrogel be directly delivered myocardium, accomplishing sustained localized delivery. Methods Results—...
Background— Endothelial progenitor cells (EPCs) possess robust therapeutic angiogenic potential, yet may be limited in the capacity to develop into fully mature vasculature. This problem might exacerbated by absence of a neovascular foundation, namely pericytes, with simple EPC injection. We hypothesized that coculturing EPCs smooth muscle (SMCs), components surrounding vascular wall, cell sheet will mimic native spatial orientation and interaction between SMCs create supratherapeutic...
After myocardial infarction, there is an inadequate blood supply to the myocardium, and surrounding borderzone becomes hypocontractile.To develop a clinically translatable therapy, we hypothesized that in preclinical ovine model of modified endothelial progenitor stem cell chemokine, engineered stromal cell-derived factor 1α analog (ESA), would induce chemotaxis, limit adverse ventricular remodeling, preserve contractility.Thirty-six adult male Dorset sheep underwent permanent ligation left...
Orthotopic heart transplantation is the gold standard treatment for end-stage failure. However, persistent shortage of available donor organs has resulted in an ever-increasing waitlist and longer waiting periods transplantation. On contrary, increasing number transplants by preserving extended criteria donors donation after circulatory death hearts with Organ Care System™ (OCS) Heart System potential to provide standard, life-saving patients The objective Donation After Circulatory Death...
BackgroundRBT-1 is a combination drug of stannic protoporfin (SnPP) and iron sucrose (FeS) that elicits preconditioning response through activation antioxidant, anti-inflammatory, iron-scavenging pathways, as measured by heme oxygenase-1 (HO-1), interleukin-10 (IL-10), ferritin, respectively. Our primary aim was to determine whether RBT-1 administered before surgery would safely effectively elicit in patients undergoing cardiac surgery.MethodsThis phase 2, double-blind, randomised,...
BACKGROUND: Pathogenic concepts of right ventricular (RV) failure in pulmonary arterial hypertension focus on a critical loss microvasculature. However, the methods underpinning prior studies did not take into account 3-dimensional (3D) aspects cardiac tissue, making accurate quantification difficult. We applied deep-tissue imaging to pressure-overloaded RV uncover 3D properties microvascular network and determine whether deficient adaptation contributes failure. METHODS: Heart sections...
Background— Experimentally, exogenous administration of recombinant stromal cell–derived factor-1α (SDF) enhances neovasculogenesis and cardiac function after myocardial infarction. Smaller analogs SDF may provide translational advantages including enhanced stability function, ease synthesis, lower cost, potential modulated delivery via engineered biomaterials. In this study, computational protein design was used to create a more efficient evolution the native protein. Methods Results—...
Fulminant myocarditis with cardiogenic shock is fatal without mechanical circulatory support. Once haemodynamic stability has been established a ventricular assist device (VAD), the decision to wait for myocardial recovery as opposed listing an orthotopic heart transplant (OHT) can be difficult. We have undertaken this study establish criteria determining need transplantation following VAD implant fulminant myocarditis. A total of 442 VADs were implanted between 1993 and 2011. Twenty-four...
Posterior ventricular anchoring neochordal (PVAN) repair is a non-resectional technique for correcting mitral regurgitation (MR) due to posterior leaflet prolapse, utilizing single suture anchored in the myocardium behind leaflet. This has demonstrated clinical efficacy, although theoretical limitation stability of suture. We hypothesize that PVAN positions coaptation, after which forces are distributed evenly with low forces.Porcine valves were mounted 3-dimensional-printed heart simulator...
Background: Many graft configurations are clinically used for valve-sparing aortic root replacement, some specifically focused on recapitulating neosinus geometry. However, the specific impact of such neosinuses valvular and biomechanics potential influence long-term durability unknown. Methods: Using a custom 3-dimenstional–printed heart simulator with porcine roots (n=5), anticommissural plication, Stanford modification, straight (SG), Uni-Graft, Valsalva were tested in series using an...