A5081091973- Pulmonary Hypertension Research and Treatments
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- Lymphatic System and Diseases
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Peripheral Neuropathies and Disorders
- Eicosanoids and Hypertension Pharmacology
- Autoimmune and Inflammatory Disorders Research
- Food Allergy and Anaphylaxis Research
- Respiratory Support and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Inhalation and Respiratory Drug Delivery
- Childhood Cancer Survivors' Quality of Life
- Cardiac Fibrosis and Remodeling
- Cancer, Hypoxia, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Fibroblast Growth Factor Research
- Dysphagia Assessment and Management
- Cancer survivorship and care
- Bone health and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Palliative Care and End-of-Life Issues
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
The University of Texas MD Anderson Cancer Center
2025
University of California, Davis
2021-2024
VA Palo Alto Health Care System
2015-2020
Stanford University
2015-2020
Palo Alto University
2019
University of Colorado Denver
2015
Virginia Commonwealth University
2015
University of Michigan
2015
Michigan Medicine
2015
Lymphedema is a common debilitating condition with very limited treatment options, and leukotriene B 4 may be key pathogenic molecule therapeutic target.
Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it currently unknown whether how Treg function differentially affects males females. Objective: To evaluate deficiency male female rats in experimental PH. Methods Results: Male athymic rnu/rnu rats, lacking Tregs, were treated the VEGFR2 (vascular endothelial growth factor receptor 2) inhibitor SU5416 or chronic hypoxia...
A recent study demonstrated a significant role for leukotriene B4 (LTB4) causing pulmonary vascular remodeling in arterial hypertension. LTB4 was found to directly injure luminal endothelial cells and promote growth of the smooth muscle cell layer arterioles. The purpose this determine effects on adventitial layer, largely composed fibroblasts. Here, we demonstrate that enhanced human artery fibroblast proliferation, migration, differentiation dose-dependent manner through its cognate...
Background: Bmpr2 (bone morphogenetic protein receptor 2) mutations are critical risk factors for hereditary pulmonary arterial hypertension (PAH) with approximately 20% of carriers developing disease. There is an unmet medical need to understand how environmental factors, such as inflammation, render mutants susceptible PAH. Overexpressing 5-LO (5-lipoxygenase) provokes lung inflammation and transient PAH in +/ - mice. Accordingly, its metabolite, leukotriene B 4 , candidates the second...
Hypoxia-inducible factors (HIFs), especially HIF-1α and HIF-2α, are key mediators of the adaptive response to hypoxic stress play essential roles in maintaining lung homeostasis. Human animal genetics studies confirm that abnormal HIF correlates with pulmonary vascular pathology chronic diseases, but it remains unclear whether endothelial cell production is for microvascular health. The large airway has an ideal circulatory bed evaluating histological changes physiology genetically modified rodents.
Increased ferric iron in allografts triggers a switch the growth of mold Aspergillus fumigatus from colonizing to an invasive phenotype.
Rationale: Endothelial injury may provoke emphysema, but molecular pathways of disease development require further discernment. Emphysematous lungs exhibit decreased expression HIF-2α (hypoxia-inducible factor-2α)-regulated genes, and tobacco smoke decreases pulmonary concentrations. These findings suggest that is important in the emphysema.Objectives: The objective this study was to evaluate roles endothelial-cell (EC) pathogenesis emphysema mice.Methods: Mouse were examined for after...
Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human mouse lymphedema, there is a significant increase inducible factor 1 α (HIF-1α), but reduction HIF-2α protein expression endothelial cells (LECs). We questioned whether dysregulated these transcription factors contributes to disease pathogenesis found that LEC-specific deletion Hif2α exacerbated pathology. Even without vascular injury, the loss...
Autoimmunity, allergy, and transplant rejection are a collection of chronic diseases that currently incurable, drastically decrease patient quality life, consume considerable health care resources. Underlying each these is dysregulated immune system results in the mounting an inflammatory response against self or innocuous antigen. As consequence, afflicted patients required to adhere lifelong regimens multiple immunomodulatory drugs control disease reclaim agency. Unfortunately, current...