A5100461747- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Proteoglycans and glycosaminoglycans research
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- Lipid metabolism and biosynthesis
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Fibroblast Growth Factor Research
- Cancer Research and Treatments
- Physiological and biochemical adaptations
- Nanoparticle-Based Drug Delivery
- Phytochemical Studies and Bioactivities
- Peroxisome Proliferator-Activated Receptors
- High Altitude and Hypoxia
- Kruppel-like factors research
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
Chengdu Medical College
2024
Hubei University of Chinese Medicine
2023
First Affiliated Hospital of Zhengzhou University
2022
Chinese Academy of Fishery Sciences
2021
Stanford University
2019
VA Palo Alto Health Care System
2019
University of Maryland, Baltimore
2016-2019
Hebei Medical University
2018
Second Hospital of Hebei Medical University
2018
Second Military Medical University
2012
Hypoxia-inducible factors (HIFs), especially HIF-1α and HIF-2α, are key mediators of the adaptive response to hypoxic stress play essential roles in maintaining lung homeostasis. Human animal genetics studies confirm that abnormal HIF correlates with pulmonary vascular pathology chronic diseases, but it remains unclear whether endothelial cell production is for microvascular health. The large airway has an ideal circulatory bed evaluating histological changes physiology genetically modified rodents.
Drug resistance is a major factor for the limited efficacy of chemotherapy in gastric cancer treatment. Hypoxia-inducible factor-1α (HIF-1α), central transcriptional hypoxia, suggested to participate resistance. Here, we identified hypoxia-mimic (cobalt chloride) sensitive cell line BGC-823 explore whether diosgenin, an aglycone steroidal saponins, can inhibit invasion and survival solid tumor hypoxic mimic microenvironment. We have shown that diosgenin potent candidate decreasing ability...