A5101680488- Metabolomics and Mass Spectrometry Studies
- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- ATP Synthase and ATPases Research
- Biomarkers in Disease Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Plant biochemistry and biosynthesis
- Heat shock proteins research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Inflammatory mediators and NSAID effects
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Renal Diseases and Glomerulopathies
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Intestinal and Peritoneal Adhesions
- Hernia repair and management
- Anesthesia and Neurotoxicity Research
- Adrenal and Paraganglionic Tumors
- Peroxisome Proliferator-Activated Receptors
Hubei University of Chinese Medicine
2019-2025
Harbin Institute of Technology
2021-2025
Sir Run Run Shaw Hospital
2023
Zhejiang University
2023
Hebei North University
2022
Ministry of Industry and Information Technology
2021-2022
Peking University First Hospital
2019-2020
Peking University
2019-2020
Hyogo Medical University
2018-2019
State Key Laboratory of Oral Diseases
2015-2017
Postoperative adhesion formation often ruins the quality of life or is an obstacle to illnesses with curative operation such as cancer. Previously we demonstrated that interferon-γ-promoted fibrin deposition drove postoperative formation. However, its underlying cellular and molecular mechanisms remain poorly understood. We found myofibroblasts predominantly expressed signature molecules mesothelial cells line serosa. Microarray analysis revealed IL-6 a key player, supported by elevated...
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for synthesis metabolism tumor cells. If it inhibit activity glycolysis-related enzymes control energy tumor, be targeted treatment malignant tumor. The target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2) glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics reverse docking. We detected binding constant active...
Rural areas face increasing threats from water-related disasters yet often lack the infrastructure and resources available in urban for effective disaster response recovery. Understanding improving rural resilience—the ability to withstand recover disasters—is critical sustainable development, especially under pressures climate. This study introduces a practical, indicator-based framework evaluate resilience by analyzing five key aspects: stability, hazards, exposure, vulnerability,...
The flavonoid quercitrin has a strong antioxidant property. It is also reported to have protective effect on the liver. However, mechanism by which it exerts liver not fully understood. objective of this article confirm extracted from Albiziae flos acetaminophen (APAP)-induced injury and explain its mechanism. In in vivo study, was administered orally BALB/c mice at dose 50, 100, 200 mg/kg for seven consecutive days. APAP (300 mg/kg) injected intraperitoneally after last administered....
Salivary analysis can be used to assess the severity of caries. Of known salivary proteins, a paucity information exists concerning role proteinase 3 (PR3), serine protease chymotrypsin family, in dental Whole, unstimulated saliva was collected from children with varying degrees active caries and tested using Human Protease Array Kit an enzyme-linked immunosorbent assay. A significantly decreased concentration PR3 noted increasing (P<0.01); positive correlation (r=0.87; P<0.01; Pearson's...
The high expression of fatty acid synthase (FAS) in tumor cells is consistent with their elevated requirement for acids cell membrane synthesis and energy supply to support almost unlimited proliferation. levels FAS are related proliferation, invasion, metastasis. This study investigated the possible bioactive ingredients (fraxin, esculetin, scopolin et al.) Cortex Fraxini effects on interaction between specific proteins. We used microscale thermophoresis (MST) show that our target protein,...
Our research aimed to look into the clinical traits and genetic mutations in sporadic non-syndromic anodontia gain insight role of PAX9, MSX1, AXIN2 EDA phenotypes, especially for PAX9. Material Methods The female proband her family members from ethnic Han families underwent complete oral examinations received a retrospective review. Venous blood samples were obtained screen variants AXIN2, genes. A case-control study was performed on 50 subjects with tooth agenesis (cases) 100 healthy...
Coronavirus disease (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly infectious viral disease. Clinical observations have shown that Qing-Fei-Da-Yuan (QFDY) granules good anti-COVID-19 effects, but underlying molecular mechanisms are unclear. In this study, we explored potential mechanism of QFDY with regard to its effect. We first screened active chemical constituents based on pharmacodynamic activity parameters, followed screening...
This study explored the possible bioactive ingredients and target protein of Rostellularia procumbens (L.) Nees. The results optical turbidimetry revealed that ethyl acetate extraction obtained from R. Nees could inhibit platelet aggregation. Gene chip was used to investigate differentially expressed genes. According gene chip, targets compounds isolated were predicted by network pharmacology. Computational studies chinensinaphthol methyl ether neojusticin B may integrin αIIbβ3 protein....
Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation other tumors, but the function of CDK1 PDAC remains unclear. Fisetin is a bioactive flavonoid with anti-tumor properties multiple while its CSCs elusive. In this study, we demonstrated that was correlated prognosis highly expressed tissue gemcitabine-resistant cells. Silencing impaired stemness...
Background Chikusetsusaponin IVa (CHS) is a triterpenoid saponin that has been demonstrated to possess multiple properties. Purpose This study focused on inhibiting H9N2 avian influenza virus (AIV) by CHS and investigated the underlying mechanisms, specifically targeting nuclear factor erythroid2-related 2 (Nrf2) signaling pathway. Methods The antiviral activity of was evaluated determining its half inhibitory concentration therapeutic index (TI) in vitro. Markers oxidative stress,...