A5033417378- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Malaria Research and Control
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Congenital Diaphragmatic Hernia Studies
- Esophageal Cancer Research and Treatment
- Nanowire Synthesis and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric health and respiratory diseases
- Craniofacial Disorders and Treatments
- Respiratory and Cough-Related Research
- Gastric Cancer Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal Tumor Research and Treatment
- Asthma and respiratory diseases
- Signaling Pathways in Disease
- Cancer Cells and Metastasis
- Organic Electronics and Photovoltaics
- interferon and immune responses
Nanxi Mountain Hospital
2024
Jinan University
2013-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Xian Yang Central Hospital
2024
State Key Laboratory of Respiratory Disease
2014-2023
Guangzhou Medical University
2009-2023
First Affiliated Hospital of Guangzhou Medical University
2014-2023
Shandong Eye Hospital
2022
National Clinical Research
2020-2021
Fudan University
2011
The high frequency of epidermal growth factor receptor (EGFR) mutations in tyrosine kinase inhibitor-responsive non-small-cell lung cancer (NSCLC) cases is now well established, highlighting the predictive value activating EGFR guiding clinical use EGFR-targeted therapies. However, specimen source and methods for mutation analysis are limited by tissue availability technical feasibility application. Therefore, current study designed to establish a blood-based approach assessment NSCLC...
Abstract Objective NUT midline carcinoma (NMC), a rare type of squamous cell carcinoma, is genetically characterised by family member 1 (NUTM1) gene rearrangement. NMC can arise from the lungs; however, there no standard for management primary pulmonary NMC. This study aimed to confirm clinical features and report treatments, especially with immune checkpoint inhibitors (ICIs), outcomes patients Methods A retrospective review was performed in First Affiliated Hospital Guangzhou Medical...
Investigations on the effects of malaria infection cancer mortality are limited except for incidence Burkitt's lymphoma (BL) in African children. Our previous murine lung model study demonstrated that significantly inhibited tumor growth and prolonged life span tumor-bearing mice. This aims to assess possible associations between human mortality.We compiled data worldwide age-standardized related 30 types 56 countries period 1955-2008, analyzed their longitudinal correlations by a...
Circulating tumor cells (CTCs) represent a collection of heterogeneous cells. Studies have shown epithelial CTCs and folate receptor (FR) positive could be used as diagnostic biomarkers for lung cancer (LC). This study aimed to determine whether cell surface vimentin (CSV) biomarker LC well.78 treatment-naïve non-small-cell (NSCLC) patients, 21 patients with benign diseases (BLD) 9 healthy donors (HD) were enrolled in this study. CTC detection was performed using CytoSorter® mesenchymal kit...
Accumulating research have reported that microRNAs (miRNAs) play important roles in Retinoblastoma (RB). Nonetheless, the function and underlying mechanism of miR-181a-5p RB remain ambiguous.The relative expression levels NRAS mRNA were detected by quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR). cell proliferation was measured using Cell Counting Kit-8 (CCK-8) 5'-Bromo-2'-deoxyuridine (BrdU) assays. Transwell assays flow cytometry performed to detect migration,...
Background Rearranged during transfection (RET) fusion is a kind of uncommon mutation (about 1%) in non-small cell lung cancer (NSCLC). Although selective tyrosine kinase inhibitors (TKI) (selpercatinib and pralsetinib) have been available, there are no real-world data about the difference efficacy between RET-TKI other regimens China. Methods We conducted multicenter retrospective analysis 49 patients with RET-fusion-positive NSCLC. The characteristics clinical outcomes RET-TKI,...
Checkpoint inhibitor-related pneumonitis (CIP) induced by immune checkpoint inhibitors (ICIs) is one of the most fatal immune-related adverse events (irAE). However, only limited data are available on rechallenge with ICIs after CIP. We evaluated efficacy and safety CIP in patients advanced lung cancer to identify potential populations that would benefit.We conducted a multicenter retrospective study who received further ICI treatment (rechallenge) or did not undergo re-administration grade...
The interfacial transport properties and density of states (DOS) CuPc near the dielectric surface in an operating organic field-effect transistor (OFET) are investigated using Kelvin probe force microscopy. We find that carrier mobility on high-k Al2Oy/TiOx (ATO) dielectrics under a channel electrical field 4.3 × 10(2) V/cm reaches 20 times as large SiO2. DOS highest occupied molecular orbital (HOMO) ATO substrate has Gaussian width 0.33 ± 0.02 eV, traps gap is small 7 10(17) cm(-3). A state...
Immune checkpoint inhibitors have radically changed the landscape of antitumor therapies in several malignancies. Despite long-term efficacy, severe immune-related adverse events (irAEs) were not uncommon. However, fatal simultaneous multiorgan failure was rare. Here, we described a patient who developed failure, including fulminant myocarditis, myasthenia gravis crisis, hepatic dysfunction, and delayed pneumonitis after pembrolizumab therapy for lung large-cell neuroendocrine carcinoma....
Checkpoint inhibitor-related pneumonitis (CIP) is a lethal immune-related adverse event. However, the development process of CIP, which may provide insight into more effective management, has not been extensively examined. We conducted multicenter retrospective analysis 56 patients who developed CIP. Clinical characteristics, radiological features, histologic and laboratory tests were analyzed. After comprehensive analysis, we proposed acute, subacute, chronic phases CIP summarized each...
The study aimed to analyze the efficacy and safety of combination regimen anlotinib S-1 for Chinese patients with EGFR mutation-negative advanced squamous cell lung cancer (SqCLC) poor performance status (PS,2-3) after progression second-line or later-line chemotherapy.Clinical data 70 SqCLC PS scores 2-3 treated in First Affiliated Hospital Guangzhou Medical University between January 1, 2018 September 31, 2019 who failed second- more-line treatment were analysed retrospectively. divided...
This study compares first-line pembrolizumab plus chemotherapy with alone for patients HER2-negative advanced gastric cancer (GC) and gastroesophageal junction (GEJC) in China.
The most serious, and maybe fatal, yet rare, adverse reaction of gefitinib erlotinib is drug-associated interstitial lung disease (ILD), which has been often described. However, it less well described for icotinib, a similar orally small-molecule tyrosine kinase inhibitor (TKI). case 25-year-old female patient with stage IV adenocarcinoma who developed fatal ILD reported here. She denied chemotherapy, received palliative treatment icotinib (125 mg po, three times daily) on March 1, 2013. One...
To evaluate the clinical outcomes of single-stage surgery for treatment patients with congenital ptosis and coexisting strabismus.A retrospective analysis was performed on 10 (17 eyes) strabismus. Patients were treated levator resection or frontalis suspension ocular muscle strabismus, as a procedure. Levator in 9 (15 flap 1 patient (2 blepharophimosis. Seven (11 simultaneously underwent exotropia correction, inferior oblique myectomy 3 (3 superior palsy.Satisfactory efficacy correction...
We present the case of an old woman with ALK-rearranged stage IV lung adenocarcinoma who received crizotinib. She presented severe dyspnea on 34th day, and diffuse ground-glass opacifications in her chest. A diagnosis crizotinib-induced ILD was confirmed. Corticosteroids were administered. However, disease still progressing rapidly. Therefore, as a monoclonal antibody against vascular endothelial growth factor, bevacizumab administered low doses (200 mg days one three). Her symptoms began to...
Objective: To explore the clinical characteristics, treatment, and prognosis of patients with blastic plasmacytoid dendritic cell neoplasm. Method: Clinical records 6 diagnosed neoplasm in our hospital from January 2008 to May 2016 were collected retrospectively analyzed. Results: Six manifested initial symptoms skin lesions, other common included bone marrow involvement (5/6) , lymphadenectasis (4/6) splenomegaly hepatomegaly (3/6) . In addition, extra-nodal except was also observed,...
Nonbacterial thrombotic endocarditis (NBTE) is a rare disease that most often found post mortem. Malignant neoplasms, particularly adenocarcinomas, are the common underlying diseases associated with NBTE. In recent years, remarkable advances in targeted therapy have been made, but effectiveness treating NBTE patients severe lung cancer poorly reported. Here we present two cases of stage IV adenocarcinoma harboring driver gene mutations, one EGFR mutation, other positive ALK fusion oncogene....
OBJECTIVE: To relieve large airway obstruction in a patient with advanced non-small cell lung cancer (NSCLC) by injecting the mouse-human chimeric monoclonal antibody radiolabeled iodine 131 tumor necrotic treatment ( I-chTNT) and to study irradiation absorption critical organs.METHODS: A 50-year-old NSCLC was treated radioimmunotherapy.His still obstructed spite of intensive chemotherapy radiotherapy. 131I-chTNT injected into at right bronchus through fiberscope.A I scan performed during...