A5102710063- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Tuberous Sclerosis Complex Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Education, Safety, and Science Studies
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Pediatric health and respiratory diseases
- Antifungal resistance and susceptibility
- Medication Adherence and Compliance
- Diverse Approaches in Healthcare and Education Studies
- Histiocytic Disorders and Treatments
- Nutrition and Health in Aging
- Lung Cancer Research Studies
- Body Composition Measurement Techniques
- Inhalation and Respiratory Drug Delivery
- Eosinophilic Esophagitis
- Cancer Immunotherapy and Biomarkers
- Education and Learning Interventions
- Neonatal Respiratory Health Research
- Pasture and Agricultural Systems
- Disability Education and Employment
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2010-2025
The First Affiliated Hospital, Sun Yat-sen University
2010-2025
Yanbian University Hospital
2025
Northeast Normal University
2024
Beijing Chao-Yang Hospital
2023-2024
Capital Medical University
2023-2024
Chungnam National University
2023
Taiyuan Normal University
2023
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Rationale: Host antioxidant defense, consisting of enzymatic activity and nonenzymatic micronutrients, is implicated in asthma pathogenesis. Studies defense adult incident have either used measures antioxidants estimated from questionnaires or not considered aspects host defense.Objectives: We conducted the first study designed powered to investigate association defenses on asthma.Methods: In a nested case–control study, we followed Shanghai women (aged 40–70 years) without prevalent at...
Abstract Background Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant disorder caused by pathogenic variants in either the TSC1 or TSC2 gene. Common manifestations of TSC have been grouped into major and minor clinical diagnostic criteria assessed routine workup. However, case studies point towards existence disease to potential association with malignant tumors. In this study we sought characterize malignancies using large cohort patients. Methods TuberOus SClerosis...
Background: Bronchial provocation test (BPT) plays a crucial role in diagnosing airway hyper-responsiveness (AHR) among patients with asthma-like symptoms. Given that BPT may induce severe bronchospasm, baseline spirometric parameters are expected to help predict positive outcome, guiding the decision of referring patient BPT. Methods: Baseline spirometry and conducted on suspected asthmatics between July 2011 2013 at Department Pulmonary Medicine, Zhongshan Hospital, were retrospectively...
This study explored the effects of microRNA-19b (miR-19b) on airway remodeling, inflammation, and degree oxidative stress in a mouse model asthma. Bioinformatics analyses dual luciferase reporter gene assays revealed that thymic stromal lymphopoietin (TSLP) is direct target miR-19b. An asthma was established via ovalbumin (OVA) sensitization challenge 72 female BALB/c mice. Mice were then assigned to saline, OVA-sensitized, saline+miR-19b mimics, saline+anti-TSLP, OVA-sensitized+miR-19b...
Background In China, the prevalence of severe asthma with eosinophilic phenotype is rising, yet treatment options are limited. Mepolizumab first targeted biologic therapy for eosinophilic-driven disease in China. This study (clinicaltrials.gov identifier NCT03562195 ) evaluated efficacy and safety mepolizumab Chinese patients asthma. Methods The phase III, multicentre, randomised, placebo-controlled, double-blind, parallel-group enrolled aged ≥12 years asthma, two or more exacerbations...
Abstract Background Tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND) have unique, individual patterns that pose significant challenges for diagnosis, psycho-education, and intervention planning. A recent study suggested it may be feasible to use TAND Checklist data data-driven methods generate natural clusters. However, the had a small sample size from only two countries. Here, we investigated replicability of identifying clusters larger more diverse TOSCA study....
Objective: The main objective of the present study is to evaluate psychometric properties Chinese version Beliefs about Medicines Questionnaire-specific among asthma patients; and assess association between patients' belief adherence inhaled corticosteroid therapy. Methods: A cross-sectional survey was carried out in clinic Zhongshan Hospital, Fudan University (Shanghai, China) April 2016 March 2018. translated into according international guidelines. Internal consistency, test–retest...
Abstract Purpose To cross-sectionally and longitudinally investigate the correlations of sarcopenia its components with peak expiratory flow (PEF) among Chinese community-dwelling elderly people. Methods The data were extracted from China Health Retirement Longitudinal Study (CHARLS). A total 4053 participants aged ≥ 60 years enrolled CHARLS 2011, 2810 followed up until 2015. Participants classified into no-sarcopenia, non-severe sarcopenia, severe groups based on skeletal muscle mass index...
Abstract Background Lymphangioleiomyomatosis (LAM) is a rare disease which easily misdiagnosed. Vascular endothelial growth factor D (VEGF-D), as the most common biomarker, however, not so perfect for diagnosis and severity assessment of LAM. Materials methods The isobaric tags relative absolute quantitation (iTRAQ)-based method was used to identify cytoskeleton protein, moesin. 84 patients with LAM, 44 other cystic lung diseases (OCLDs), 37 healthy control subjects were recruited collecting...
Multiple genetic and environmental factors impact the pathogenesis of asthma. ADAM33 (a disintegrin metalloproteinase domain 33) represents a novel susceptibility gene for asthma in several diverse populations. The aim this study was to determine whether single nucleotide polymorphisms (SNPs) associate with severity Chinese Han population.A total 224 subjects were enrolled, including 74 normal controls 150 asthmatic patients. enrollees further categorized into high- or low-severity groups...
Abstract Background Most NSCLCs metastasised out of the lungs at time diagnosis and cannot be surgically removed . Cytotoxic chemotherapy drugs have become main treatment in recent decades, especially patients with NSCLC without EGFR, ALK, ROS gene mutations. The prognosis lung cancer is poor, overall 5-year survival rate only 9–13%. Therefore advanced remains a significant medical need. Recent studies shown relationship between gut-lung axis microecology malignant tumors. Intestinal...
Allergic asthma is a heterogeneous disease with complex underlying mechanisms. Cytokines are key mediators in immune system and potential indicators of status. The aim this study to compare the difference serum cytokine profile allergic patients different severity explore candidate biomarkers for monitoring targeting therapeutic agents.A total 40 asthmatics (mild, n=22; moderate-to-severe, n=18) were included study. Serum samples, lung function exhaled nitric oxide data collected from each...
To investigated the influence of illness perceptions and other risk factors related to poor asthma control quality life in adult outpatients with China. Patients a confirmed diagnosis were recruited from outpatient clinic at Zhongshan Hospital, Fudan University Shanghai. Sociodemographic, psychological, variables assessed all participants. Patients' perceptions, medication adherence, control, using validated questionnaires, such as Brief Illness Perception Questionnaire, Medication Adherence...
This study aimed to investigate the relationship between illness perceptions, medication beliefs, and self-reported adherence inhaled corticosteroid (ICS) therapy in adult Chinese patients with asthma.A cross-sectional survey was conducted asthma outpatient clinic of Zhongshan Hospital, Fudan University (Shanghai, China) October 2018 September 2019. Illness were assessed using validated scales, specifically Medication Adherence Report Scale for Asthma, Beliefs about Medicines Questionnaire...
Background: The epidemiology and severity of asthma vary by sex age. diagnosis, treatment, management in female patients are quite challenging. However, there is hitherto no comprehensive standardized guidance for with asthma. Methods: Corresponding search strategies were determined based on clinical concerns regarding Search terms included “sex hormones lung development”, hormone changes asthma”, “hormones immune response”, “women, “children, “puberty, “menstruation, “pregnancy, “lactation,...