A5101686948- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Selenium in Biological Systems
- Carcinogens and Genotoxicity Assessment
- Ferroptosis and cancer prognosis
- Air Quality and Health Impacts
- Mycotoxins in Agriculture and Food
- Cancer, Lipids, and Metabolism
- Air Quality Monitoring and Forecasting
- Natural product bioactivities and synthesis
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Flavonoids in Medical Research
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Cassava research and cyanide
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
Shanghai Tenth People's Hospital
2015-2025
Tongji University
2015-2025
Fudan University Shanghai Cancer Center
2025
Shanghai Pulmonary Hospital
2013-2024
China Agricultural University
2015-2024
Huzhou Women and Children's Hospital
2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Clinical Research Center
2024
Shanghai University of Sport
2023
Recently, the morbidity and mortality from lung cancer have continued to increase. Mitochondrial dysfunction plays a key role in apoptosis, proliferation, bioenergetic reprogramming of cells, especially for energy metabolism. Herein, we investigated ability melatonin (MLT) influence growth explored association between mitochondrial functions progression tumors. The deacetylase, sirtuin 3 (Sirt3), is pivotal player maintenance function, among participating ATP production by regulating...
Abstract This study investigates the impact of financial development, nonrenewable energy, renewable and trade openness on ecological footprint from 1990 to 2020 under new hypothetical imitations economic complexity‐induced environmental Kuznets curve (EKC) framework in BRICS‐T economies. After verifying potential cross‐sectional dependency, this employed second‐generation panel data tests estimate consistent, unbiased, robust results. The key results research discover that influence...
Standard neoadjuvant regimens for HER2-positive breast cancer include trastuzumab and pertuzumab combined with chemotherapy, the efficacy safety of third-generation HER2-direted antibody-drug conjugate (ADC) remain to be elucidated. This open-label, randomized, phase 2 study enrolled patients aged 18 years or older stage II-III Her2-positive cancer. Patients were randomly assigned (1:1:1) receive treatment either SHR-A1811 monotherapy, pyrotinib, nab-paclitaxel carboplatin, trastuzumab,...
Circulating microRNAs (miRNAs) are potential noninvasive biomarkers for cancer detection. We used preoperative serum samples from non-small cell lung (NSCLC) patients and healthy controls to investigate whether levels of candidate miRNAs could be as diagnostic in with resectable NSCLC they were associated clinicopathologic characteristics. initially detected expression 12 using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) 94 58 controls. further validated our...
The effects of berberine on the metastatic potential lung cancer cells and its underlying mechanisms have not been fully elucidated. Since epithelial-to-mesenchymal transition is a cellular process associated with invasion metastasis, we attempted to investigate use as an inhibitor TGF-β1-induced in A549 cells. In this study, investigated anticancer activity against vitro vivo. BBR-induced apoptosis human was determined by flow cytometry. ability BBR inhibit TGF-β-induced EMT examined...
Recent studies have implied that miRNAs may play a crucial role in tumor progression and be involved the modulation of some drug resistance cancer cells. Earlier demonstrated miR-194 was metastasis non-small cell lung (NSCLC), whereas their expression roles on NSCLC still need further elucidation. In current study, we found is decreased samples compared with adjacent non-cancerous samples, low predicts poor patient survival. Both vitro vivo experiments showed ectopic stable suppressed...
Water-soluble inorganic (WSI) ions are major components of ambient air PM2.5 (particulate matter diameter ≤2.5 μm); however, their potential health effects understudied. On C57BL/6 mice, we quantified the effect three WSIs (NO3–, SO42–, and NH4+) on respiratory systems. Exposure scenarios include different WSI types, concentrations, animal development stages (young vs adult), sex. The exposure were comprehensively assessed, with special focus function tissue/cell level changes. Chronic NO3–...
Abstract Surgery is the common treatment for early lung cancer with multiple pulmonary nodules, but it often accompanied by problem of significant malignancy other nodules in non-therapeutic areas. In this study, we found that a combined local radiofrequency ablation (RFA) and melatonin (MLT) greatly improved clinical outcomes patients minimizing function injury reducing probability malignant transformation or enlargement non-ablated Mechanically, as demonstrated an associated mouse tumor...
Abstract Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits development OXPHOS‐targeting treatment. Here, lines sensitive or resistant OXPHOS are identified by screening. inhibition‐sensitive cells possess increased activity and silenced nicotinamide N ‐methyltransferase (NNMT) expression. NNMT expression negatively correlates with functionally downregulates intracellular levels S‐adenosyl...
Abstract BACKGROUND: It has been established that “ret proto‐oncogene” ( RET ) fusions are oncogenic drivers in non–small cell lung cancer (NSCLC). The prevalence and clinicopathologic characteristics of Chinese patients with NSCLC remain unclear. objective the current study was to determine KIF5B‐RET (fusions kinesin family member 5B [ KIF5B ] genes) NSCLC. METHODS: authors screened for 392 using multiplex real‐time polymerase chain reaction assay validated all positive samples direct...
Background: Berberine (BBR) from the widely used Chinese herbal medicine Huanglian has an array of pharmacological and biochemical properties, including anti-neoplastic activity. However, specific mechanisms underlying these properties are unknown. The aim this study was to explore anti-tumor BBR in non-small cell lung cancer (NSCLC). Methods: effects on NSCLC tumor development programmed death were investigated both vivo vitro. Luciferase reporter assays determine whether tissue factor (TF)...
Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung (NSCLC) patients with wild-type EGFR. To clarify role EMT phenotype as a marker EGFR-TKI, we performed retrospective study 202 stage IV or recurrent NSCLC receiving gefitinib erlotinib therapy...
Patulin is one of the common food-borne mycotoxins. Previous studies have demonstrated that patulin can cause diverse toxic effects in animals including hepatotoxicity and nephrotoxicity. In present study, we addressed protective effect two forms selenium compounds methylseleninic acid (MSeA) sodium selenite on patulin-induced nephrotoxicity using both vitro vivo models. Results showed MSeA at concentrations 3–5 μM, not same concentrations, capable protecting against cytotoxicity cell...
Abstract Patulin is a major mycotoxin found in fungal contaminated fruits and their derivative products. Previous studies showed that patulin was able to induce increase of reactive oxygen species (ROS) generation oxidative stress suggested play pivotal role patulin-induced multiple toxic signaling. The objective the present study investigate functional p53 stress. Our demonstrated higher levels ROS DNA damage were induced wild-type cell lines than either knockdown or knockout response...