A5100351500- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- ATP Synthase and ATPases Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aldose Reductase and Taurine
- Infant Nutrition and Health
- Milk Quality and Mastitis in Dairy Cows
- Aquaculture disease management and microbiota
- Plant Pathogenic Bacteria Studies
- Child Nutrition and Water Access
- Nitric Oxide and Endothelin Effects
- Coenzyme Q10 studies and effects
- Retinal Development and Disorders
- Cardiac electrophysiology and arrhythmias
- Bioenergy crop production and management
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Plant-Microbe Interactions and Immunity
- Pediatric health and respiratory diseases
- Invertebrate Immune Response Mechanisms
- Ion channel regulation and function
- Metabolomics and Mass Spectrometry Studies
- Vibrio bacteria research studies
- Genomics, phytochemicals, and oxidative stress
- Curcumin's Biomedical Applications
Northwest A&F University
2024
Central South University
2024
Chinese Academy of Engineering
2024
Nanjing Agricultural University
2006-2023
Yunnan Agricultural University
2023
Henan Agricultural University
2022
Shandong Agricultural University
2022
Nanjing University
2020-2021
Peking University First Hospital
2021
Peking University
2021
Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that have been implicated in innate immune response to bacterial infection. Neutrophils express high levels of peptidylarginine deiminase 4 (PAD4), which catalyzes histone citrullination. However, whether PAD4 or citrullination plays a role structure is unclear. In this study, we show the hypercitrullination histones by mediates decondensation. Histone detected on HL-60...
Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed peptidylarginine deiminase 4 (PAD4) correlates with decondensation during NET formation. However, the role of PAD4 in NET-mediated bacterial trapping killing has not been tested. Here, we use knockout mice to show is essential for antibacterial function. Unlike PAD4(+/+) neutrophils, PAD4(-/-)...
Fasting and glucose shortage activate a metabolic switch that shifts more energy production to mitochondria. This adaptation ensures supply, but also elevates the risk of mitochondrial oxidative damage. Here we present evidence metabolically challenged mitochondria undergo active fusion suppress stress. In response starvation, mitofusin 1 (MFN1) becomes associated with protein deacetylase HDAC6. interaction leads MFN1 deacetylation activation, promoting fusion. Deficiency in HDAC6 or...
Recently, the morbidity and mortality from lung cancer have continued to increase. Mitochondrial dysfunction plays a key role in apoptosis, proliferation, bioenergetic reprogramming of cells, especially for energy metabolism. Herein, we investigated ability melatonin (MLT) influence growth explored association between mitochondrial functions progression tumors. The deacetylase, sirtuin 3 (Sirt3), is pivotal player maintenance function, among participating ATP production by regulating...
Abstract Background The soil-borne fungal pathogen Verticillium dahliae Kleb causes wilt in a wide range of crops including cotton ( Gossypium hirsutum ). To date, most upland varieties are susceptible to V. and the breeding for with resistance has not been successful. Results Hpa1 Xoo is harpin protein from Xanthomonas oryzae pv. which induces hypersensitive cell death plants. When hpa1 was transformed into line Z35 through Agrobacterium -mediated transformation, transgenic (T-34) an...
Abstract Establishing mixed‐species plantations has become the most promising planting method to provide various goods and improve multiple environmental services. Although mixed potential increase tree biomass, divergent findings make it challenging understand mixing effects on whole forest (trees, shrubs, herbs, litter) biomass. Therefore, we conducted a meta‐analysis compiling 156 studies published from 1982 2021 across 128 sites in China. We aimed quantify biomass between monocultures...
Neutrophil extracellular traps (NETs) are produced by neutrophil activation and usually have both anti-infective pro-damage effects. Streptococcus uberis ( S. ), one of the common causative organisms mastitis, can lead to production NETs. Taurine, a free amino acid abundant in organism, has been shown immunomodulatory In this study, we investigated molecular mechanisms -induced NETs formation regulatory role taurine. The results showed that had disruptive effect on mammary epithelial cells...
Taurine may alleviate the inflammatory injury induced by Streptococcus uberis (S. uberis) infection regulating intracellular Ca2+ levels. However, underlying mechanisms remain unclear. Infection leads to subversion of phosphoinositides (PIs) which are closely related signaling. In order investigate whether taurine regulates inflammation means PIs/ systems, competitive inhibitors (β-alanine) siTauT, siPAT1, siPLC, siCaN, siPKC, and PLC (U73122), PKC (RO31-8220) CaN (FK 506) were used. The...
This study aimed to assess the effects of feeding with different forage sources and starter concentrations on growth performance, nutrient digestibility, ruminal fermentation, microbial community in weaned Holstein calves. A total 54 calves (body weight (BW) = 77.50 ± 5.07 kg; age 70 2.54 days) were assigned 1 3 treatment groups ( n 18/group) that offered diets forages: (1) peanut vine (PV), (2) oat hay (OH), or (3) an alfalfa + combination (alfalfa hay:oat =1:1, AO). Starter intakes...
CD4+CD25+ regulatory T cells (Tregs) exert a suppressive activity on atherosclerosis but the underlying mechanism remains unclear. Here, we investigated whether and how Tregs affect oxLDL-induced proinflammatory response in macrophages. were isolated by magnetic cell sorting-column analyzed flow cytometry. Macrophages cultured with or without presence of oxLDL for 48 hours to induce response. Our data showed that challenge, Treg-modulated macrophages have decreased NO production iNOS...
An indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) based on monoclonal antibodies (MAbs) for benzothiostrobin has been developed. The hapten of was synthesized and conjugated to bovine serum albumin ovalbumin generate an immunogen a coating antigen. used immunize BALB/c mice, resulting in anti-benzothiostrobin MAb. Under optimal conditions, the half maximal inhibition concentration (IC50) limit detection (IC10) developed ic-ELISA were 7.55 0.428 μg L−1, respectively....
Bubble-enhanced shock waves induce the transient opening of blood-brain barrier (BBB) providing unique advantages for targeted drug delivery brain tumor therapy, but little is known about molecular details this process. Based on our BBB model including 28 000 lipids and 280 tight junction proteins coarse-grained dynamics simulations, we provided molecular-level mechanism three typical drugs first time, lipophilic paclitaxel, hydrophilic gemcitabine, siRNA encapsulated in liposome, across...