A5100361387- Mitochondrial Function and Pathology
- melanin and skin pigmentation
- Immunodeficiency and Autoimmune Disorders
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
- ATP Synthase and ATPases Research
- Cardiac Arrest and Resuscitation
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Metabolism and Genetic Disorders
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Bone and Dental Protein Studies
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Neuroscience and Neuropharmacology Research
- Cell death mechanisms and regulation
- Respiratory viral infections research
- Dermatologic Treatments and Research
- Hematological disorders and diagnostics
- Neuroblastoma Research and Treatments
- Autophagy in Disease and Therapy
Kunming Children's Hospital
2016-2025
Kunming Medical University
2012-2025
Central South University
2019-2025
Second Xiangya Hospital of Central South University
2019-2025
First Hospital of Shanxi Medical University
2024-2025
Shanxi Medical University
2024-2025
Case Western Reserve University
2013-2025
Sun Yat-sen University
2019-2025
Sun Yat-sen Memorial Hospital
2025
Sichuan University
2012-2024
Mitochondria are complex organelles with a highly dynamic distribution and internal organization. Here, we demonstrate that mitofilin, previously identified mitochondrial protein of unknown function, controls cristae morphology. Mitofilin is enriched in the narrow space between inner boundary outer membranes, where it forms homotypic interaction assembles into large multimeric complex. Down-regulation mitofilin HeLa cells by using specific small interfering RNA lead to decreased cellular...
AlkB homolog 5 (ALKBH5) has been proven to be closely related tumors. However, the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely reported.The potential functional single-nucleotide polymorphisms (SNPs) were identified by National Center for Biotechnology Information (NCBI) dbSNP screening SNPinfo software. TaqMan probes used genotyping. A multiple logistic regression model was evaluate effects different SNP loci on risk neuroblastoma. The expression neuroblastoma...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause end-stage renal disease (ESRD). However, there still lack effective prevention treatment strategies in clinical practice. As metabolic disease, DN accompanied by ectopic lipid deposition, the deposited lipids further aggravate kidney injury. molecular mechanism deposition currently unknown. In this study, we observed changes droplet (LD)–mitochondria connections for first time. Destruction...
A reliable predictor for early recovery of consciousness in comatose patients is great clinical significance. Here we aimed to investigate the potentially prognostic value electroencephalogram-reactivity (EEG-R) combination with sleep spindles, termed EEG-awakening, behavioral awakening etiologically diverse patients. We performed a prospectively observational study on sample patients, all whom were coma lasting longer than 3 days. Continuous EEG monitoring was at least 24 h detect presence...
BackgroundThe mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, it plays vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed MAM, serves as an antioxidant reduces ER stress. However, of DsbA-L MAM kidney pathobiology remains unclear.MethodsMolecular biology techniques, transmission electron microscopy (TEM), situ proximity ligation assays (PLAs),...
Neuroblastoma is the primary cause of cancer death in childhood. METTL14 tightly linked to cancer. However, whether single-nucleotide polymorphisms (SNPs) gene could predispose neuroblastoma susceptibility lacks evidence. With an epidemiology case-control study, associations between SNPs and overall risk for were estimated 898 cases 1,734 controls. Following that, stratified analysis was performed. Among five analyzed SNPs, rs298982 G>A rs62328061 A>G exhibited a significant association with...
Vitiligo on extremities and/or bony prominences is very resistant to treatment. Twenty-five patients with symmetrical and stable vitiligo were enrolled. The treatment side received fractional carbon dioxide laser followed by topical compound betamethasone solution narrowband ultraviolet B phototherapy. control plus result of showed that 44% achieved over 50% re-pigmentation patient satisfaction score was 5.12 ± 3.23, higher than those (p < 0.05). Adverse events slight tolerable. triple...
BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only proapoptotic member of the Bcl-2 family. Because interaction proteins with intracellular Ca(2+) stores has been linked to apoptosis, role transfer between endoplasmic reticulum (ER) and mitochondria in BNIP3-mediated cell death was determined rat dopaminergic neuronal line, Mes 23.5. mutants were constructed target either ER or mitochondria. Localization membrane facilitated release subsequently increased uptake into...
Recent studies suggest that oxidative stress and mitochondrial dysfunction play important roles in the neurotoxicity of nickel. Because DNA (mtDNA) is highly vulnerable to melatonin can efficiently protect mtDNA against damage various pathological conditions, aims this study were determine whether was involved nickel assay neuroprotective effects mtDNA. In study, we exposed mouse neuroblastoma cell lines (Neuro2a) different concentrations chloride (NiCl(2), 0.125, 0.25, 0.5 mm) for 24 hr. We...
Kalu U.E. Ogbureke 1,2,3 , Paul M. Weinberger 2 Stephen W. Looney 1,3 Li 4 Larry Fisher 1 College of Dental Medicine, Georgia Health Sciences University, 1120 15th Street, Augusta, GA Medical Georgia, 3 Graduate Studies, Craniofacial and Skeletal Disease Branch, National Institute Research, NIH, 30 Convent Drive, Building 30, Room 228, Bethesda, MD Received: January 23, 2012; Accepted: March 2, Published: 11, Keywords: Oral Cancer, DSPP, BSP, OPN, MMPs, Tumor-Free Margin Correspondence:...
Polydatin is thought to protect mitochondria in different cell types various diseases. Mitochondrial dysfunction a major contributing factor secondary brain injury resulting from traumatic injury. To investigate the protective effect of polydatin after injury, rat model lateral fluid percussion was established mimic insults. Rat models were intraperitoneally injected with (30 mg/kg) or SIRT1 activator SRT1720 (20 mg/kg, as positive control polydatin). At 6 hours post-traumatic insults,...
Hermansky-Pudlak syndrome (HPS) is a rare recessive disorder characterized by hypopigmentation, bleeding diathesis, and other symptoms due to multiple defects in lysosome-related organelles. Ten HPS subtypes have been identified with mutations HPS1 HPS10. Only four patients HPS-1 reported Chinese population. Using next-generation sequencing (NGS), we screened 100 hypopigmentation genes HPS-1, two HPS-3, one HPS-5, three HPS-6 typical ocular or oculocutaneous albinism the absence of platelet...
Lipid peroxidation is a complex biochemical process associated with oxidative stress, and its products play crucial roles in cellular signaling the pathophysiology of many diseases. Among diverse array lipid (LPO) products, epoxyketooctadecenoic acids (EKODEs) have emerged as intriguing molecules potential impacts on inflammatory EKODEs arise from linoleic acid reacting reactive oxygen nitrogen species present during inflammation. A hallmark LPO an electrophilic chemical functionality that...
Objective Prostate cancer (PC) is the most common malignant tumour in men, and atherosclerotic cardiovascular disease (ASCVD) leading cause of non-cancer death PC patients. The main purpose this study was to investigate whether chemotherapy increases heart-specific mortality (HSM) elderly patients with PC. Methods Patient information downloaded from Surveillance, Epidemiology, End Results (SEER) database 2010 2018. We included all multivariate logistic regression model used explore...