A5081306083- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Hair Growth and Disorders
- Renal Diseases and Glomerulopathies
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Nanocomposite Films for Food Packaging
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Acute Kidney Injury Research
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- Ophthalmology and Eye Disorders
- Facial Rejuvenation and Surgery Techniques
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Immune Cell Function and Interaction
- Thyroid Cancer Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Facial Nerve Paralysis Treatment and Research
- Advanced Glycation End Products research
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2006-2025
Guangxi Medical University
2025
China Three Gorges University
2010-2025
Hebei Eye Hospital
2025
Weatherford College
2025
Case Western Reserve University
2025
Shanxi Medical University
2016-2025
Huazhong Agricultural University
2024
Donghua University
2024
Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation; however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived burn-induced inflammation is not well understood. We found that burn injury significantly increased inflammatory reaction rats or macrophages exposed to lipopolysaccharide (LPS), tumor necrosis factor α (TNF-α) interleukin-1β (IL-1β) levels decreased IL-10 levels. hUCMSC-exosome administration...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause end-stage renal disease (ESRD). However, there still lack effective prevention treatment strategies in clinical practice. As metabolic disease, DN accompanied by ectopic lipid deposition, the deposited lipids further aggravate kidney injury. molecular mechanism deposition currently unknown. In this study, we observed changes droplet (LD)–mitochondria connections for first time. Destruction...
Cancer remains a leading global cause of mortality, making early detection crucial for improving survival outcomes. The study aims to develop machine learning-enabled blood-derived exosomal RNA profiling platform multi-cancer and localization. In this multi-phase, multi-center study, we analyzed from exosomes derived peripheral blood plasma in 818 participants across eight cancer types during the discovery phase. Machine learning techniques were applied identify potential pan-cancer...
Pancreatic cancer (PaCa) has a dismal prognosis and adjuvant immunotherapy frequently is of low efficacy due to immunosuppressive features PaCa PaCa-stroma. We here explored, whether the vaccination with tumor-exosome (TEX)-loaded dendritic cells (DC) can be improved by combining drugs affecting myeloid-derived suppressor (MDSC). Experiments were performed UNKC6141 line. TEX-loaded DC weekly intravenously injected, mice additionally receiving Gemcitabine (GEM) and/or ATRA Sunitinib (Sun)....
Increasing evidence has demonstrated that hypoxia was an aggressive feature in endometrial cancer (EC), which is significantly associated with the tumor grade, lymph node metastasis, and resistance to chemotherapy. However, relationship between immune microenvironment EC not very clear. Exosomes are small membrane vesicles secreted from a variety of cell types mediate cell-to-cell communication through transported biomolecules. Here, we investigated whether exosomes can play immunomodulatory...
Background Sarcopenia, characterized by impaired muscle mass and function, is a common complication the main reason for bad life quality high mortality in chronic kidney disease (CKD). Limiting systemic inflammation potable intervention sarcopenia. Dietary inflammatory potential can influence inflammation. However, research about association between dietary sarcopenia CKD limited. Aim To investigate population. Methods We conducted cross-section study based on public database of National...
Abstract Neurosyphilis (NS) is a central nervous system (CNS) infection caused by Treponema pallidum ( T. ). NS can occur at any stage of syphilis and manifests as broad spectrum clinical symptoms. Often referred to “the great imitator,” be easily overlooked or misdiagnosed due the absence standard diagnostic tests, potentially leading severe irreversible organ dysfunction. In this study, proteomic machine learning model techniques are used characterize 223 cerebrospinal fluid (CSF) samples...
Coronavirus disease 2019 (COVID-19) patients with impact on skin and hair loss are reported. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is detected in the of some patients; however, detailed pathological features tissues from infected SARS-CoV-2 at a molecular level limited. Especially, ability to infect cells their function not well understood. A proteome map COVID-19 established here susceptibility human-induced pluripotent stem cell (hiPSC)-derived organoids follicles...
Recent advances in cochlear implantology are exemplified by novel functional strategies such as bimodal electroacoustic stimulation, which the patient has intact low-frequency hearing and profound high-frequency pre-operatively. Therefore, synergistic restoration of dysfunctional hair cells protection from ototoxic insults have become a persistent target pursued for this hybrid system. In study, we developed composite GelMA/PEDOT:PSS conductive hydrogel that is suitable coating implant...
The ever-increasing therapeutic and pharmaceutical demand for liver cells calls systems that enable mass production of hepatic cells. Here we describe a large-scale suspension system uses human endoderm stem (hEnSCs) as precursors to generate functional transplantable hepatocytes (E-heps) or cholangiocytes (E-chos). hEnSC-derived populations are characterized by single-cell transcriptomic analyses compared with hESC-derived counterparts, in-vitro-maintained -expanded primary adult cells,...
Diet management is a pivotal intervention for chronic kidney disease (CKD) patients. Dietary inflammation index (DII) developed to evaluate the integral inflammatory potential of diet pattern. However, research about association between DII and mortality in CKD limited. We conducted cohort study investigate relationship energy-adjusted (E-DII) 5-year all-cause cardiovascular population. participants with complete E-DII data death status from National Health Nutrition Examination Survey...
Leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) was reported to be an inhibitory molecule with suppressive functions. sEVs mediate communication between cancer cells and other cells. However, the existence of LILRB2 on in circulation function sEVs-LILRB2 are still unknown. This study aims investigate role GBM determine how regulates tumor immunity.LILRB2 expression normal brain tissues detected by immunohistochemistry, effect prognosis evaluated orthotopic model. Next, a...
Rationale: Blepharoptosis is a common disorder characterized by abnormal eyelid position that affects both visual function and esthetics. Postoperative upper retraction, which often due to overcorrection, major problem. Under normal circumstances, the operation usually performed on overcorrected eye. Here, we present case of patient who had previously undergone surgery correct right blepharoplasty, resulted in asymmetry. Utilizing Hering’s law, decided only left eye, resulting remarkable...
Excessive neuroinflammation resulting from chronic alcohol intake is an important risk factor for central nervous system injury. The aim of this study was to investigate the effect kaempferol (KAE) on alcohol-induced neural injury and its underlying mechanism. C57BL/6 N mice were employed develop a binge-on-chronic exposure model, with different doses KAE as interventional drug 6 weeks. Neuronal damage microglial activation in brain, well colonic tissue serum lipopolysaccharide (LPS)...
Circular RNA (circRNA) affects the occurrence and development of human cancers, but specific mechanism hepatocellular carcinoma (HCC) has not yet been fully understood. CircRNAs were determined by circRNA array analysis quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell viability, migration, invasion, other indicators used for cell function analysis. Knockdown overexpression techniques to explore circCORO1C in HCC sequencing, qRT-PCR, western blot, methods. Among...