A5066279304- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Phytochemical Studies and Bioactivities
- Sperm and Testicular Function
- Medicinal Plants and Bioactive Compounds
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Electrochemical sensors and biosensors
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- NF-κB Signaling Pathways
- Molecular Sensors and Ion Detection
- Phytochemistry and Bioactive Compounds
University of South China
2023-2025
Institute of Subtropical Agriculture
2018-2025
First Affiliated Hospital of GuangXi Medical University
2024-2025
Guangxi Medical University
2024-2025
Chinese Academy of Sciences
2018-2025
China Three Gorges University
2013-2024
College of Medical Sciences
2024
Hunan Normal University
2019-2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2020
Second Hospital of Yichang
2019-2020
Trametenolic acid B (TAB) was a lanostane-type triterpenoid isolated from the trametes lactinea (Berk.) Pat. We have previously reported that extract Pat and TAB could efficiently improve learning memory ability of cerebral ischemia injury rats suppress mitochondrial-mediated apoptosis in hydrogen peroxide damaged SH-SY5Y cells. However, potential mechanisms not been fully understood yet. The current study to further investigate protective effect on oxygen glucose deprivation/reoxygenation...
Increasing evidence has demonstrated that hypoxia was an aggressive feature in endometrial cancer (EC), which is significantly associated with the tumor grade, lymph node metastasis, and resistance to chemotherapy. However, relationship between immune microenvironment EC not very clear. Exosomes are small membrane vesicles secreted from a variety of cell types mediate cell-to-cell communication through transported biomolecules. Here, we investigated whether exosomes can play immunomodulatory...
Objective— Measures of HDL (high-density lipoprotein) function are associated with cardiovascular disease. However, the effects regular exercise on these measures is largely unknown. Thus, we examined different doses 3 in 2 randomized clinical trials. Approach and Results— Radiolabeled boron dipyrromethene difluoride–labeled cholesterol efflux capacity HDL-apoA-I (apolipoprotein A-I) exchange were assessed before after 6 months training cohorts: STRRIDE-PD (Studies Targeted Risk Reduction...
Total flavonoids of Epimedium (TFE) is the main active composition that has been used to treat male reproductive problems. The present aim was investigate protective effects TFE on mice system against cyclophosphamide (CP)‐induced oxidative injury. animals were treated with CP make testicular injury model and observed. In CP‐treated group, epididymal weights, sperm count motility significantly decreased relative control group ( P < 0.05 0.01, respectively). Compared (200 400 mg/kg)...
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for treatment of diseases and stroke China. In this study, we investigated anti-apoptotic effect PNS on cardiomyocytes natural aging rat explored potential mechanisms regarding oxidative stress mitochondrial function signaling pathways. Male Sprague-Dawley rats were randomly divided into five groups: adult control (3-month old), (24-month different doses PNS-treated groups (10, 30, 60 mg/kg/day, orally)....
// Chengfu Yuan 1 , Chaoqi Liu Ting Wang Yumin He Zhiyong Zhou Yaoyan Dun Haixia Zhao Dongming Ren Junjie 2 Changcheng Zhang Ding College of Medical Science, China Three Gorges University, Yichang, HuBei 443002, Renhe Hospital Correspondence to: Yuan, email: yuancf46@ctgu.edu.cn Zhang, greatwall1@ctgu.edu.cn yuancf46@163.com Wang, junjiewang@ctgu.edu.cn Keywords: chikusetsu saponin IVa, adipose tissue inflammation, NLRP3 inflammasome, NF-κB signaling, ASC pyroptosome Received: January 23,...
The decreased renal function is known to be associated with biological aging, of which the main pathological features are chronic inflammation and interstitial fibrosis. In previous studies, we reported that total saponins from Panax japonicus (SPJs) can availably protect acute myocardial ischemia. We proposed SPJs might have similar protective effects for aging-associated Thus, in present study, evaluated overall effect on fibrosis.Sprague-Dawley (SD) aging rats were given by gavage...
Perfluorooctane sulfonate (PFOS) is widely recognized as causing Sertoli cell injury and testicular toxicity in males. Icariin a flavonoid from Epimedium, which effectively improves spermatogenesis disturbance induced by several factors clinic. However, it unclear whether icariin PFOS-induced toxicity. In vivo, fifty-two male mice were randomly separated into four groups: normal control group, model low high doses of icariin-treated groups, with 13 each group. Except for the group groups...
Abstract Recent scientific studies have highlighted the importance of long-chain noncoding RNAs (lncRNAs) in a variety metabolic diseases, but specific functions and mechanisms lncRNAs aberrant lipid synthesis associated with aging are unknown. In this work, we inspected effects on metabolism mice, as substantial evidence suggests that disturbs metabolism. The results revealed expression lncRNA Gm15232 was significantly elevated epididymal white adipose tissue mice compared to adult mice....
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects improve testicular dysfunction the clinical setting. However, whether icariin improves age-related degeneration of function via protection cell injury remains unclear. In present study, we evaluated protective effect on explored possible mechanism(s) vivo vitro. Dietary administration for 4 months significantly ameliorated decline...
Objective: To evaluate the effectiveness and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with stage 4/M neuroblastoma (NB). Methods: This study was a prospective, single-arm, multicenter clinical trial conducted by Sun Yat-sen Memorial Hospital, Children's Hospital Nanjing Medical University, Zhejiang University School Medicine, First Affiliated Guangxi Xinhua to Shanghai Jiao Tong Medicine. From March 1, 2019 August 31, 2023, 25 confirmed NB received...
BACKGROUND Stage IV pancreatic cancer (PC) has a poor prognosis and lacks individualized prognostic tools. Current survival prediction models are limited, there is need for more accurate, personalized methods. The Surveillance, Epidemiology, End Results (SEER) database offers valuable resource studying large patient cohorts, yet machine learning-based nomograms stage PC remain underexplored. This study hypothesizes that nomogram can predict cancer-specific (CSS) overall (OS) with high...
Renal interstitial fibrosis (RIF) is a crucial pathological change leading to chronic kidney disease (CKD). Currently, no effective medicines have been available for treating it. In our research, we examined the effects of polysaccharides extracted from Balanophora polyandra Griff (BPPs) on and epithelial mesenchymal transition (EMT) in vivo vitro, aiming explore underlying mechanisms. By using mice with unilateral urethral obstruction (UUO) as experimental subjects, medicinal values BPPs...