A5100740042- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Plasma Applications and Diagnostics
- Global Cancer Incidence and Screening
- Neuroblastoma Research and Treatments
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Obesity and Health Practices
- Eating Disorders and Behaviors
- Electrospun Nanofibers in Biomedical Applications
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Obesity, Physical Activity, Diet
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Prostate Cancer Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Advanced biosensing and bioanalysis techniques
- Surface Modification and Superhydrophobicity
- Economic and Financial Impacts of Cancer
Peking University Cancer Hospital
2015-2025
Peking University
2015-2025
117th Hospital of People's Liberation Army
2024-2025
Tianjin Medical University
2025
Guangzhou University of Chinese Medicine
2025
Chinese People's Liberation Army
2025
Royal College of Surgeons of England
2019-2024
Royal College of Surgeons in Ireland
2022-2024
Tongji University
2020-2024
Fanjingshan National Nature Reserve
2024
Abstract Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared cells, cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic ethical issues. Exosomes can inherit similar therapeutic effects...
A tri-fluid electrospinning process was successfully developed to prepare tri-chamber complex nanofibers. The core–shell and Janus structure were combined form a delicate complicated architecture for solving the problem of co-administration quercetin tamoxifen citrate, improving oral bioavailability, enhancing their synergistic anti-breast cancer actions. Scanning electron microscope, transmission microscope confocal fluorescent microscopy images showed designed Fourier transform infrared...
Glycosaminoglycan (GAG) side chains endow extracellular matrix proteoglycans with diversity and complexity based upon the length, composition charge distribution of polysaccharide chain. Using cultured primary neurons, we show that specific sulfation in GAG chondroitin sulfate mediates neuronal guidance cues axonal growth inhibition. Chondroitin-4-sulfate (CS-A), but not chondroitin-6-sulfate (CS-C), exhibits a strong negative cue to mouse cerebellar granule neurons. Enzymatic gene-based...
Cold atmospheric plasma (CAP) is an emerging and promising oncotherapy with considerable potential advantages that traditional treatment modalities lack. The objective of this study was to investigate the effect mechanism plasma-inhibited proliferation plasma-induced apoptosis on human lung cancer colon cells in vitro vivo . Piezobrush ® PZ2, a handheld CAP unit based piezoelectric direct discharge technology, used generate deliver non-thermal plasma. Firstly, PZ2 inhibited HT29 colorectal...
Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and fourth leading cause of cancer-related death worldwide. Advanced or metastatic HCC currently managed using systemic drug therapy with unsatisfactory patient survival. Cold atmospheric plasma has emerged as a promising, physicochemical, broad-spectrum oncotherapy. In this preclinical study, we investigated anti-neoplastic functions mechanism piezoelectric direct discharge technology-based CAP, Piezo-CAP, on in vitro vivo....
Recent advances in cochlear implantology are exemplified by novel functional strategies such as bimodal electroacoustic stimulation, which the patient has intact low-frequency hearing and profound high-frequency pre-operatively. Therefore, synergistic restoration of dysfunctional hair cells protection from ototoxic insults have become a persistent target pursued for this hybrid system. In study, we developed composite GelMA/PEDOT:PSS conductive hydrogel that is suitable coating implant...
Introduction Allergic rhinitis (AR) is an upper airway inflammatory disease of the nasal mucosa. Conventional treatments such as symptomatic pharmacotherapy and allergen-specific immunotherapy have considerable limitations drawbacks. As emerging therapy with regenerative potential immunomodulatory effect, mesenchymal stem cell-derived exosomes (MSC-Exos) recently been trialed for treatment various autoimmune diseases. Methods In order to achieve sustained protected release MSC-Exos...
Convincing evidence revealed that some platinum-based drugs could stimulate immunological recognition, thereby inducing immunogenic cell death (ICD). Indoleamine-2,3-dioxygenase (IDO) is overexpressed in tumors, which caused exhaustion of tryptophan (T-cell energy) and constructed an immunosuppressive tumor microenvironment. Herein, considering IDO inhibition to improve chemotherapy, a series IDOi-Pt(IV) prodrugs were designed not only target DNA but also facilitate tumor-antigen exposure...
<i>Background:</i> There is limited research on how patients prefer physicians to communicate about the topic of obesity, and there even less understanding which terms most commonly use. <i>Methods:</i> In this cross-sectional, nonrandom sampling study, who were seeking treatment for weight loss rated desirability 12 describe excess weight, likelihood with they would use those during clinical encounters. Participants a 5-point scale, −2 representing “very undesirable” or “definitely not use”...
Brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to be associated with poor prognosis in neuroblastoma (NB) patients. Our previous studies indicated that BDNF activation of induces chemo-resistance through phosphoinositide-3-kinase (PI3K)/Akt pathway. In this study, we investigated the role BDNF/TrkB on metastasis NB. A tetracycline-regulated TrkB-expressing NB cell line (TB3) was used. Scratch wound healing assay, Boyden chamber migration,...
Recently, totally laparoscopic gastrectomy has been gradually accepted by surgeons worldwide for gastric cancer treatment. Complete dissection of the lymph nodes and establishment surgical margin are most important considerations curative surgery. Previous studies have demonstrated that indocyanine green (ICG)-traced significantly improves completeness node dissection. However, it remains difficult to identify tumor location intraoperatively cancers staged ≤T3. Here, we investigated...
Head and neck cancer (HNC) is the seventh most prevalent globally, often characterized by chemo-resistance immunosuppression, which significantly hampers treatment efficacy. Cold atmospheric plasma (CAP) has recently emerged as a promising adjuvant oncotherapy with substantial potential advantages. In this study, Piezobrush® PZ2, handheld CAP unit based on piezoelectric direct discharge technology, was used to generate deliver non-thermal plasma. We aimed investigate effects of CAPPZ2...
Activated AKT is a marker of decreased event-free or overall survival in neuroblastoma (NB) patients. The aim this study was to investigate the effect perifosine, nontoxic inhibitor, as single agent on NB cell growth vitro and vivo. Four human lines (AS, NGP, BE2, KCNR) were treated with increasing concentrations quantitative analysis death (apoptosis) performed by using MTS caspase-3/7 activity assays. Survival mice carrying xenograft tumors that perifosine (n = 6–7 per group) compared...
We have produced Bioglass coatings for Orthopedic implants by using a novel coating technique, CoBlast. The two resultant surfaces, designated BG and hydroxyapatite (HA)/BG, were compared with their HA counterpart, OsteoZip in terms of osteoblastic cell attachment, adhesion, proliferation, differentiation, growth factor production. HA/BG demonstrated goniometry to be more hydrophilic than OsteoZip. This corresponded enhanced protein adsorption, adhesion documented both quantitative...